摘要
三阴性乳腺癌表现出侵袭性的乳腺癌亚型,进一步缺乏有效的治疗策略和预后指标。 TNBC中的基因组异质性导致肿瘤和癌症干细胞复发,发生远端转移的可能性更高。几项研究支持以下观点:miRNA可能在TNBC中充当癌基因或抑癌基因。通过靶向转录后调控影响转移事件的几个基因,miRNA可以作为TNBC的全局调控子,但是尚未阐明诱导该作用的确切机制。在这篇综述中,我们总结了miRNA表达,它可以通过靶向上皮到间质转化,转移性定植,癌干细胞,侵袭,迁移和转移来功能性抑制TNBC中的转移级联。 miRNA可能作为转移性生物标志物出现,以预测TNBC在肺,脑和淋巴结中的远端复发。 miRNA可以作为转移性TNBC的预后标志物,从而预测受影响患者的总体生存期,无病生存期和远处无转移生存期。本综述文章旨在深入了解可能作为一种有效治疗策略,远端复发的新型生物标志物和转移性TNBC的预后标志物而出现的miRNA库。
关键词: 生物标记物,miRNA,转移,预后,TNBC,肿瘤抑制剂。
Current Cancer Drug Targets
Title:Potential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer
Volume: 21 Issue: 2
关键词: 生物标记物,miRNA,转移,预后,TNBC,肿瘤抑制剂。
摘要: Triple-negative breast cancer presents an aggressive form of breast cancer subtype, which further lacks efficient treatment strategies and prognostic markers. Genomic heterogeneity in TNBC has led to the relapse of tumor and cancer stem cells with a higher likelihood of distal metastasis. Several studies supported the notion that miRNAs may act as oncogene or tumor suppressors in TNBC. miRNAs may function as a global regulator of TNBC by targeting post-transcriptional regulation of several genes involved in influencing metastatic events, but the exact mechanism involved in inducing the effect is yet to be elucidated. In this review, we summarized miRNA expression, which can functionally suppress metastatic cascade in TNBC by targeting epithelial to mesenchymal transition, metastatic colonization, cancer stem cells, invasion, migration and metastasis. miRNAs may appear as a metastatic biomarker to predict distal reoccurrence of TNBC in lungs, brain and lymph nodes. miRNA can act as a prognostic marker in metastatic TNBC, thereby predicting overall survival, disease-free survival and distant metastasis-free survival in affected patients. The present review article is an attempt to gain an insight into the repertoire of miRNA that may emerge out as an effective treatment strategy, novel biomarker of distal reoccurrence and prognostic marker in metastatic TNBC.
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Potential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer, Current Cancer Drug Targets 2021; 21 (2) . https://dx.doi.org/10.2174/1568009620999201103201626
DOI https://dx.doi.org/10.2174/1568009620999201103201626 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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