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Mini-Review Article

解读细胞因子对类风湿关节炎治疗策略的作用

卷 22, 期 7, 2021

发表于: 27 October, 2020

页: [803 - 815] 页: 13

弟呕挨: 10.2174/1389450121666201027124625

价格: $65

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摘要

类风湿关节炎(RA)是一种全身性、慢性、自身免疫性、炎症性疾病，影响大小滑膜关节的对称模式。RA一开始是关节疼痛的炎症，导致关节僵硬、关节破坏，并进一步恶化病情，对关节造成永久性不可逆损伤，使其残疾。在全球范围内，约有120万例风湿性关节炎病例。尽管有各种可用的治疗和药理学药物对抗风湿性关节炎，但没有一种治疗能保证完全治愈。深入了解细胞因子和白细胞介素在RA疾病发病机制中的作用，有助于开发它们来开发新的治疗策略。本文综述了RA的发病机制，并简要概述了在疾病进展中发挥重要作用的细胞因子。我们还讨论了白细胞介素在RA中的可能作用，这可能有助于未来的研究人员探索它们，以确定新的治疗药物。

关键词: 类风湿关节炎，细胞因子，白细胞介素，TNF-α， IL-1

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图形摘要

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