摘要
随着新药和新疗法的选择,前列腺癌全身治疗的方案正在迅速发展。为了更新共享的泌尿肿瘤实践的背景知识,我们回顾了目前在全身治疗中的陈述和标志。非转移性和转移性疾病的许多新药物正在研究中。同样,正在开发新的目标成像技术,以提高对真正的非转移和真正转移患者的检测率。五种新药已显示对转移性前列腺癌的无进展生存率和总体生存率有效。但是,这些治疗方法的最佳顺序需要进一步研究。新药的耐受性和副作用以及它们对疾病的活性也是至关重要的问题。泌尿肿瘤科团队必须及时了解新的医学疗法,以便有信心与参与前列腺癌决策的其他专业人员进行辩论。在多学科小组讨论中,应分享不同的观点和细微差别,以实现疾病管理中的平衡决策。
关键词: 前列腺癌,雄激素剥夺治疗,抗雄激素,前列腺癌单位,多西他赛,全身治疗。
Current Cancer Drug Targets
Title:Management of Prostate Cancer with Systemic Therapy: A Prostate Cancer Unit Perspective
Volume: 21 Issue: 2
关键词: 前列腺癌,雄激素剥夺治疗,抗雄激素,前列腺癌单位,多西他赛,全身治疗。
摘要: The scenario of systemic therapy for prostate cancer is rapidly evolving, with new drugs and new treatment options. To update the background knowledge of shared uro-oncologic practice, we reviewed current statements and landmarks in systemic therapy. A number of new agents are under investigation in non-metastatic and metastatic disease. Similarly, new target imaging technologies are under development to improve the detection rate of true non-metastatic and true metastatic patient. Five new drugs have shown to be effective on progression-free and overall survival in metastatìc prostate cancer. However, the optimal sequencing of these treatments requires further investigation. The tolerability and side effects of the new drugs are also crucial issues to be discussed, as well as their activity against the disease. The uro-oncologic team has to stay updated about new medical therapies in order to be confident in debating with other professionals involved in prostate cancer decision making. Different points of view and nuances should be shared during multidisciplinary group discussions to achieve a balanced decision in disease management.
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Cite this article as:
Management of Prostate Cancer with Systemic Therapy: A Prostate Cancer Unit Perspective, Current Cancer Drug Targets 2021; 21 (2) . https://dx.doi.org/10.2174/1568009620666201021163919
DOI https://dx.doi.org/10.2174/1568009620666201021163919 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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