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摘要
肺纤维化(Pulmonary fibrosis, PF)是最常见的慢性进行性间质性肺疾病,主要发生于老年人,诊断后中位生存期为2-4年。它的高死亡率是由于其一般症状导致诊断延误,更重要的是由于缺乏有效的治疗。MicroRNAs (miRNAs)是一类小的非编码RNA,参与许多必要的细胞过程,包括细胞外基质重塑、肺泡上皮细胞凋亡、上皮-间充质转化等。我们总结了近年来TGF-β信号通路介导的PF中具有双重作用的异常miRNAs,如抗纤维化的let-7家族和前纤维化的miR-21成员。因此,本文将介绍miRNA的最新应用,为PF的治疗提供新的方向。
关键词: 肺纤维化,microRNAs,转化生长因子-β,细胞外基质,上皮-间充质转化,前纤维化
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