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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

ESRP1新出现的多种癌症调节作用：控制EMT的替代剪接的编排

卷 20, 期 9, 2020

页: [654 - 665] 页: 12

弟呕挨: 10.2174/1568009620666200621153831

价格: $65

摘要

RNA结合蛋白（RBP）与新生和成熟的RNA结合以执行生物学功能，例如选择性剪接和RNA稳定性。具有独特的RNA识别结合基序，RBP以基于序列和结构的方式与RNA形成复合物。已经在肿瘤发生和癌症进展中鉴定了几种RBP的异常表达。这些不受控制的RBP影响几种机制，包括细胞增殖，肿瘤生长，侵袭，转移和化学耐药性。上皮剪接调节蛋白1（ESRP1）是hnRNP蛋白家族的成员，在调节众多细胞过程中起着至关重要的作用，包括在器官发生过程中多种基因的选择性剪接和翻译。 ESRP1的异常表达会改变细胞形态，并在癌症进展期间导致细胞增殖和肿瘤生长。 ESRP1介导的靶基因（包括CD44，FGFR，PTBP1，LYN，ENAH，SPAG1和ZMYND8）的选择性剪接导致癌症进展。此外，ESRP1还调节环状RNA（例如circUHRF1，circNOL10和circANKS1B）的环化和生物发生，其表达已被确定为各种癌症的关键因素。该多功能蛋白质还涉及施加靶mRNA（例如细胞周期蛋白A2）的稳定性，从而参与细胞周期调控。这篇综述的范围是研究最新的科学数据，蛋白上调和下调的结果以及ESRP1在各种癌症中的作用。我们通过总结ESRP1失调及其对各种人类癌症中靶基因的影响来得出结论。总的来说，ESRP1介导的剪接在癌细胞中的后果表明，ESRP1在细胞增殖和化学抗性中通过凋亡和自噬调节发挥作用，因此可能成为癌症治疗的潜在靶标。

关键词: ESRP1，替代剪接，EMT，癌症进展，化学耐药性，RNA结合蛋白（RBP）。

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图形摘要

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