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当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

Ⅱ型糖尿病患者血浆BACE1水平和BACE1 C786G基因多态性与认知功能的关系:横断面研究

卷 17, 期 4, 2020

页: [355 - 364] 页: 10

弟呕挨: 10.2174/1567205017666200522210957

价格: $65

摘要

背景:在Ⅱ型糖尿病(T2DM)和轻度认知障碍(MCI)的病理生理过程中,β-位点APP裂解酶1 (BACE1)是一个关键酶。我们的目的是研究Ⅱ型糖尿病MCI患者血浆BACE1水平和BACE1基因多态性与不同认知表现的潜在关联。 方法:根据蒙特利尔认知评估(MoCA)评分,将186例Ⅱ型糖尿病患者分为92例MCI组和94例健康认知对照组。对社会人口统计学特征、临床参数和神经心理学测试进行了评估。测定BACE1 C786G基因多态性及血浆BACE1水平。 结果:MCI患者血浆BACE1水平高于对照组。MCI组在调整空腹血糖、糖化血红蛋白和c肽稳态模型评估胰岛素抵抗后,血浆BACE1水平与MoCA、时钟绘制测验和逻辑记忆测验成绩呈负相关,与Trail Making Test- b时间呈正相关(均p<0.05)。多变量logistic回归分析显示,Ⅱ型糖尿病患者血浆BACE1水平高,MCI风险显著增加(OR = 1.492, p = 0.027)。T2DM-MCI患者血浆GG和GC基因型BACE1水平明显高于CC基因型(p = 0.035);p = 0.026)。 结论:血浆BACE1水平升高与T2DM-MCI患者整体认知功能低下,尤其是视空间能力、视/逻辑记忆和执行功能低下相关。此外,血浆BACE1水平升高是T2DM患者MCI的危险因素,可能与BACE1 C786G基因突变有关。

关键词: β-位点APP裂解酶1

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