Abstract
In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the green method. We review the application of isoxazole in material science, agriculture and pharmaceutical. In material science, isoxazole is used as a photochromic, electrochemical probe for Cu2+ and, given its optical properties, in dye-sensitized solar cells, high energy material and liquid crystal. In agriculture, isoxazole is used as an insecticide for managing Callosobruchus chinensis, Acaricidal activity against T. cinnabarinus, and herbicidal activities of 2-cyanoacrylates containing isoxazole. In pharmaceutical, isoxazole shows anticancer, antituberculosis, anti-inflammatory, and acetylcholinesterase inhibitors. Further, we describe various reactions of isoxazole such as ring opens, bromination and iodination, thioynol ethers, intramolecular SEAr reaction, arylation, cycloaddition and photocycloaddition, photoisomerization, Domino transformation of isoxazoles to 2,4-dicarbonyl pyrroles and rearrangement. We also describe the synthesis of 3,5-disubstituted, 3,4-disubstituted and 3,4,5-trisubstituted isoxazole using different methods.
Keywords: Agriculture, disubstituted, isoxazole, material science, pharmaceutical, reaction, synthesis, trisubstituted.
Mini-Reviews in Organic Chemistry
Title:Application, Reactivity and Synthesis of Isoxazole Derivatives
Volume: 18 Issue: 1
Author(s): Yogesh Walunj, Pravin Mhaske and Pramod Kulkarni*
Affiliation:
- Post Graduate Center in Organic Chemistry and Department of Chemistry, Hutatma Rajguru Mahavidyalaya, Rajgurunagar, Pune-410505,India
Keywords: Agriculture, disubstituted, isoxazole, material science, pharmaceutical, reaction, synthesis, trisubstituted.
Abstract: In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the green method. We review the application of isoxazole in material science, agriculture and pharmaceutical. In material science, isoxazole is used as a photochromic, electrochemical probe for Cu2+ and, given its optical properties, in dye-sensitized solar cells, high energy material and liquid crystal. In agriculture, isoxazole is used as an insecticide for managing Callosobruchus chinensis, Acaricidal activity against T. cinnabarinus, and herbicidal activities of 2-cyanoacrylates containing isoxazole. In pharmaceutical, isoxazole shows anticancer, antituberculosis, anti-inflammatory, and acetylcholinesterase inhibitors. Further, we describe various reactions of isoxazole such as ring opens, bromination and iodination, thioynol ethers, intramolecular SEAr reaction, arylation, cycloaddition and photocycloaddition, photoisomerization, Domino transformation of isoxazoles to 2,4-dicarbonyl pyrroles and rearrangement. We also describe the synthesis of 3,5-disubstituted, 3,4-disubstituted and 3,4,5-trisubstituted isoxazole using different methods.
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Cite this article as:
Walunj Yogesh , Mhaske Pravin and Kulkarni Pramod *, Application, Reactivity and Synthesis of Isoxazole Derivatives, Mini-Reviews in Organic Chemistry 2021; 18 (1) . https://dx.doi.org/10.2174/1570193X17999200511131621
DOI https://dx.doi.org/10.2174/1570193X17999200511131621 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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