免疫治疗：一种针对癌症干细胞的潜在方法

Title:Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

Volume: 21 Issue: 2

关键词: 免疫疗法，癌症干细胞，治疗应用，临床，目标，机制。

摘要: Tumor recurrence and drug resistance are two of the key factors affecting the prognosis of cancer patients. Cancer stem cells (CSCs) are a group of cells with infinite proliferation potential which are not sensitive to traditional therapies, including radio- and chemotherapy. These CSCs are considered to be central to tumor recurrence and the development of drug resistance. In addition, CSCs are important targets in cancer immunotherapy because of their expression of novel tumorassociated antigens, which result from mutations in cancer cells over the course of treatment. Emerging immunotherapies, including cancer vaccines, checkpoint blockade therapies, and transferred immune cell therapies, have all been shown to be more effective when they selectively target CSCs. Such therapies may also provide novel additions to the current therapeutic milieu and may offer new therapeutic combinations for treatment. This review summarizes the relationships between various immunotherapies and CSCs and provides novel insights into potential therapeutic applications for these approaches in the future.

Cite this article as:

Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells, Current Cancer Drug Targets 2021; 21 (2) . https://dx.doi.org/10.2174/1568009620666200504111914