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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Systematic Review Article

纳米医学：乳腺癌有效疗法发展的有希望的途径

卷 20, 期 8, 2020

页: [603 - 615] 页: 13

弟呕挨: 10.2174/1568009620666200331124113

价格: $65

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摘要

目的：乳腺癌是女性中最可能的癌症。 然而，可用的治疗是基于针对乳腺癌的不同阶段，即放射治疗，激素治疗，化学疗法和外科手术干预，这具有一定的局限性。 可用的化学疗法与诸如低溶解度，低渗透性，高首过代谢和P-糖蛋白外排等问题相关。 因此，上述限制导致无效的治疗。 多种化学疗法也可引起肿瘤抵抗。 因此，目的是通过应用纳米医学方法来开发治疗乳腺癌的有效治疗方案。 方法：本评价是根据系统的搜索策略进行的，基于截至2019年11月在Pub Med，MedlinePlus，Google Scholar和Sciencedirect上可用的相关文献，使用了摘要中存在的关键字和标题。 根据我们的纳入和排除标准，筛选了226篇文章。 在226篇文章中，总共选择了40篇文章进行此评价。 结果：目前可利用的治疗方法的重要发现是该药物除了分布到靶标特异性部位外，还分布到健康细胞中，导致严重的副作用。 而且，该药物在作用部位的生物利用度较低。 因此，为了克服这个问题，需要高剂量，这又会引起副作用并降低益处。 纳米医学方法提供了另一种方法来避免可利用的化学疗法治疗乳腺癌的相关问题。 结论：纳米药物策略可用于常规乳腺癌治疗，并使用不同的新型药物递送方法来递送靶标特异性药物。

关键词: 乳腺癌，化学疗法，生物利用度，副作用，受体靶标，纳米药物。

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[1]
DeSantis, C.E.; Ma, J.; Gaudet, M.M.; Newman, L.A.; Miller, K.D.; Goding Sauer, A.; Jemal, A.; Siegel, R.L. Breast cancer statistics. Cancer J. Clin., 2019, 69(6), 438-451.
[2]
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin., 2019, 69(1), 7-34.
[http://dx.doi.org/10.3322/caac.21551] [PMID: 30620402]
[3]
Millis, S.Z.; Gatalica, Z.; Winkler, J.; Vranic, S.; Kimbrough, J.; Reddy, S.; O’Shaughnessy, J.A. Predictive biomarker profiling of > 6000 breast cancer patients shows heterogeneity in TNBC, with treatment implications. Clin. Breast Cancer, 2015, 15(6), 473-48.
[http://dx.doi.org/10.1016/j.clbc.2015.04.008] [PMID: 26051240]
[4]
Dai, X.; Xiang, L.; Li, T.; Bai, Z. Cancer hallmarks, biomarkers and breast cancer molecular subtypes. J. Cancer, 2016, 7(10), 1281-1294.
[http://dx.doi.org/10.7150/jca.13141] [PMID: 27390604]
[5]
Weigel, M.T.; Dowsett, M. Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocr. Relat. Cancer, 2010, 17(4), R245-R262.
[http://dx.doi.org/10.1677/ERC-10-0136] [PMID: 20647302]
[6]
Iqbal, N.; Iqbal, N. Human epidermal growth factor receptor 2 (HER2) in cancers: Overexpression and therapeutic implications. Mol. Biol. Int., 2014, 2014, 852748.
[http://dx.doi.org/10.1155/2014/852748] [PMID: 25276427]
[7]
Nounou, M.I.; ElAmrawy, F.; Ahmed, N.; Abdelraouf, K.; Goda, S.; Syed-Sha-Qhattal, H. Breast cancer: conventional diagnosis and treatment modalities and recent patents and technologies; Breast Cancer Basic Clin. Res, 2015.
[8]
Wu, D.; Si, M.; Xue, H.Y.; Wong, H.L. Nanomedicine applications in the treatment of breast cancer: current state of the art. Int. J. Nanomedicine, 2017, 12, 5879-5892.
[http://dx.doi.org/10.2147/IJN.S123437] [PMID: 28860754]
[9]
Cucinotto, I.; Fiorillo, L.; Gualtieri, S.; Arbitrio, M.; Ciliberto, D.; Staropoli, N.; Grimaldi, A.; Luce, A.; Tassone, P.; Caraglia, M.; Tagliaferri, P. Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time? J. Drug Deliv., 2013, 2013, 905091.
[http://dx.doi.org/10.1155/2013/905091] [PMID: 23738077]
[10]
Matsen, C.B.; Neumayer, L.A. Breast cancer: A review for the general surgeon. JAMA Surg., 2013, 148(10), 971-979.
[http://dx.doi.org/10.1001/jamasurg.2013.3393] [PMID: 23986370]
[11]
Dhankhar, R.; Vyas, S.P.; Jain, A.K.; Arora, S.; Rath, G.; Goyal, A.K. Advances in novel drug delivery strategies for breast cancer therapy; Artificial Cells, Blood Substitutes, Biotechnol, 2010.
[http://dx.doi.org/10.3109/10731199.2010.494578]
[12]
König, J.; van Ewijk, R.; Kuhr, K.; Schmidberger, H.; Wöckel, A.; Kreienberg, R.; Blettner, M. Radiotherapy effects on early breast cancer survival in observational and randomized studies: A systematic analysis of advantages, disadvantages and differences between the two study types. Breast Cancer, 2016, 23(3), 415-424.
[http://dx.doi.org/10.1007/s12282-014-0579-2] [PMID: 25585654]
[13]
Talluri, S.V.; Kuppusamy, G.; Karri, V.V.S.R.; Tummala, S.; Madhunapantula, S.V. Lipid-based nanocarriers for breast cancer treatment - comprehensive review. Drug Deliv., 2016, 23(4), 1291-1305.
[http://dx.doi.org/10.3109/10717544.2015.1092183] [PMID: 26430913]
[14]
McDonnell, D.P.; Wardell, S.E.; Norris, J.D. oral selective estrogen receptor downregulators (SERDs), a breakthrough endocrine therapy for breast cancer. J. Med. Chem., 2015, 58(12), 4883-4887.
[http://dx.doi.org/10.1021/acs.jmedchem.5b00760] [PMID: 26039356]
[15]
Abdulkareem, I.H.; Zurmi, I.B. Review of hormonal treatment of breast cancer. Niger. J. Clin. Pract., 2012, 15(1), 9-14.
[http://dx.doi.org/10.4103/1119-3077.94088] [PMID: 22437080]
[16]
Anampa, J.; Makower, D.; Sparano, J.A. Progress in adjuvant chemotherapy for breast cancer: An overview. BMC Med., 2015, 13, 195.
[http://dx.doi.org/10.1186/s12916-015-0439-8] [PMID: 26278220]
[17]
Tao, J.J.; Visvanathan, K.; Wolff, A.C. Long term side effects of adjuvant chemotherapy in patients with early breast cancer. Breast, 2015, 24(Suppl. 2), S149-S153.
[http://dx.doi.org/10.1016/j.breast.2015.07.035] [PMID: 26299406]
[18]
Brasó-Maristany, F.; Filosto, S.; Catchpole, S.; Marlow, R.; Quist, J.; Francesch-Domenech, E.; Plumb, D.A.; Zakka, L.; Gazinska, P.; Liccardi, G.; Meier, P.; Gris-Oliver, A.; Cheang, M.C.; Perdrix-Rosell, A.; Shafat, M.; Noël, E.; Patel, N.; McEachern, K.; Scaltriti, M.; Castel, P.; Noor, F.; Buus, R.; Mathew, S.; Watkins, J.; Serra, V.; Marra, P.; Grigoriadis, A.; Tutt, A.N. PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat. Med., 2016, 22(11), 1303-1313.
[http://dx.doi.org/10.1038/nm.4198] [PMID: 27775704]
[19]
Daniel, A.R.; Gaviglio, A.L.; Knutson, T.P.; Ostrander, J.H.; D’Assoro, A.B.; Ravindranathan, P.; Peng, Y.; Raj, G.V.; Yee, D.; Lange, C.A. Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene, 2015, 34(4), 506-515.
[http://dx.doi.org/10.1038/onc.2013.579] [PMID: 24469035]
[20]
Ness, R.A.; Miller, D.D.; Li, W. The role of vitamin D in cancer prevention. Chin. J. Nat. Med., 2015, 13(7), 481-497.
[http://dx.doi.org/10.1016/S1875-5364(15)30043-1] [PMID: 26233839]
[21]
Hahne, C. J.B; Engel, J.; Honig, A.; R Meyer, S.; Zito, D.; Lampis, A.; Valeri, N. The PI3K/AKT/MTOR-signal transduction pathway as drug target in triple-negative breast cancer. Clin. Cancer Drugs, 2017, 4(1), 47-58.
[http://dx.doi.org/10.2174/2212697X04666170321112629]
[22]
Finn, R.S.; Aleshin, A.; Slamon, D.J. Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers. Breast Cancer Res., 2016, 18(1), 17.
[http://dx.doi.org/10.1186/s13058-015-0661-5] [PMID: 26857361]
[23]
Liu, D.; Wang, X.; Chen, Z. Tumor necrosis factor-α, a regulator and therapeutic agent on breast cancer. Curr. Pharm. Biotechnol., 2016, 17(6), 486-494.
[http://dx.doi.org/10.2174/1389201017666160301102713] [PMID: 26927216]
[24]
Suman, S.; Sharma, P.K.; Rai, G.; Mishra, S.; Arora, D.; Gupta, P.; Shukla, Y. Current perspectives of molecular pathways involved in chronic inflammation-mediated breast cancer. Biochem. Biophys. Res. Commun., 2016, 472(3), 401-409.
[http://dx.doi.org/10.1016/j.bbrc.2015.10.133] [PMID: 26522220]
[25]
Selli, C.; Dixon, J.M.; Sims, A.H. Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers. Breast Cancer Res., 2016, 18(1), 118.
[http://dx.doi.org/10.1186/s13058-016-0779-0] [PMID: 27903276]
[26]
Maughan, K.L.; Lutterbie, M.A.; Ham, P.S. Treatment of breast cancer. Am. Fam. Physician, 2010, 81(11), 1339-1346.
[PMID: 20521754]
[27]
Chiavenna, S.M.; Jaworski, J.P.; Vendrell, A. State of the art in anti-cancer mAbs. J. Biomed. Sci., 2017, 24(1), 15.
[http://dx.doi.org/10.1186/s12929-016-0311-y] [PMID: 28219375]
[28]
Bernard-Marty, C.; Lebrun, F.; Awada, A.; Piccart, M.J. Monoclonal antibody-based targeted therapy in breast cancer: Current status and future directions. Drugs, 2006, 66(12), 1577-1591.
[http://dx.doi.org/10.2165/00003495-200666120-00004] [PMID: 16956305]
[29]
Ahmed, A.R.; Hombal, S.M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol., 1984, 11(6), 1115-1126.
[http://dx.doi.org/10.1016/S0190-9622(84)80193-0] [PMID: 6392368]
[30]
Kaklamani, V.G.; Gradishar, W.J. Role of capecitabine (Xeloda) in breast cancer. Expert Rev. Anticancer Ther., 2003, 3(2), 137-144.
[http://dx.doi.org/10.1586/14737140.3.2.137] [PMID: 12722873]
[31]
Decatris, M.P.; Sundar, S.; O’Byrne, K.J. Platinum-based chemotherapy in metastatic breast cancer: Current status. Cancer Treat. Rev., 2004, 30(1), 53-81.
[http://dx.doi.org/10.1016/S0305-7372(03)00139-7] [PMID: 14766126]
[32]
Toschi, L.; Finocchiaro, G.; Bartolini, S.; Gioia, V.; Cappuzzo, F. Role of gemcitabine in cancer therapy; Futur. Oncol, 2005.
[http://dx.doi.org/10.1517/14796694.1.1.7]
[33]
Marupudi, N.I.; Han, J.E.; Li, K.W.; Renard, V.M.; Tyler, B.M.; Brem, H. Paclitaxel: A review of adverse toxicities and novel delivery strategies. Expert Opin. Drug Saf., 2007, 6(5), 609-621.
[http://dx.doi.org/10.1517/14740338.6.5.609] [PMID: 17877447]
[34]
Wigmore, P.M.; Mustafa, S.; El-Beltagy, M.; Lyons, L.; Umka, J.; Bennett, G. Effects of 5-FU. Adv. Exp. Med. Biol., 2010, 678, 157-164.
[http://dx.doi.org/10.1007/978-1-4419-6306-2_20] [PMID: 20738018]
[35]
Thorn, C.F.; Oshiro, C.; Marsh, S.; Hernandez-Boussard, T.; McLeod, H.; Klein, T.E.; Altman, R.B. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet. Genomics, 2011, 21(7), 440-446.
[http://dx.doi.org/10.1097/FPC.0b013e32833ffb56] [PMID: 21048526]
[36]
Yang, M.; Kim, J.S.; Kim, J.; Jang, S.; Kim, S.H.; Kim, J.C.; Shin, T.; Wang, H.; Moon, C. Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer. Brain Res. Bull., 2012, 89(1-2), 50-56.
[http://dx.doi.org/10.1016/j.brainresbull.2012.07.003] [PMID: 22796103]
[37]
Xu, Y.C.; Wang, H.X.; Tang, L.; Ma, Y.; Zhang, F.C. A systematic review of vinorelbine for the treatment of breast cancer. Breast J., 2013, 19(2), 180-188.
[http://dx.doi.org/10.1111/tbj.12071] [PMID: 23320984]
[38]
Ho, M.Y.; Mackey, J.R. Presentation and management of docetaxel-related adverse effects in patients with breast cancer. Cancer Manag. Res., 2014, 6, 253-259.
[http://dx.doi.org/10.2147/CMAR.S40601] [PMID: 24904223]
[39]
Shetty, N.; Gupta, S. Eribulin drug review. South Asian J. Cancer, 2014, 3(1), 57-59.
[http://dx.doi.org/10.4103/2278-330X.126527] [PMID: 24665449]
[40]
Dong, M.; Luo, L.; Ying, X.; Lu, X.; Shen, J.; Jiang, Z.; Wang, L. Comparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study. OncoTargets Ther., 2018, 11, 4247-4252.
[http://dx.doi.org/10.2147/OTT.S162003] [PMID: 30087568]
[41]
Rosvig, L.H.; Langkjer, S.T.; Knoop, A.; Jensen, A.B. Palliative treatment with carboplatin as late line therapy to patients with metastatic breast cancer. Acta Oncol., 2018, 57(1), 156-159.
[http://dx.doi.org/10.1080/0284186X.2017.1407495] [PMID: 29202627]
[42]
Mohit, E.; Hashemi, A.; Allahyari, M. Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines. Expert Rev. Clin. Immunol., 2014, 10(7), 927-961.
[http://dx.doi.org/10.1586/1744666X.2014.916211] [PMID: 24867051]
[43]
Gao, J.; Swain, S.M. Pertuzumab for the treatment of breast cancer: a safety review. Expert Opin. Drug Saf., 2016, 15(6), 853-863.
[http://dx.doi.org/10.1517/14740338.2016.1167185] [PMID: 26982349]
[44]
Yang, S.X. Bevacizumab and breast cancer: Current therapeutic progress and future perspectives. Expert Rev. Anticancer Ther., 2009, 9(12), 1715-1725.
[http://dx.doi.org/10.1586/era.09.153] [PMID: 19954282]
[45]
Chomoucka, J.; Drbohlavova, J.; Huska, D.; Adam, V.; Kizek, R.; Hubalek, J. Magnetic nanoparticles and targeted drug delivering. Pharmacol. Res., 2010, 62(2), 144-149.
[http://dx.doi.org/10.1016/j.phrs.2010.01.014] [PMID: 20149874]
[46]
Chidambaram, M.; Manavalan, R.; Kathiresan, K. Nanotherapeutics to overcome conventional cancer chemotherapy limitations. J. Pharm. Pharm. Sci., 2011, 14(1), 67-77.
[http://dx.doi.org/10.18433/J30C7D] [PMID: 21501554]
[47]
Bikiaris, D.; Papageorgiou, G.Z.; Stergiou, A.; Pavlidou, E.; Karavas, E.; Kanaze, F.; Georgarakis, M. Physicochemical studies on solid dispersions of poorly water-soluble drugs: evaluation of capabilities and limitations of thermal analysis techniques. Thermochim. Acta, 2005.
[http://dx.doi.org/10.1016/j.tca.2005.09.011]
[48]
Liu, Y.; Solomon, M.; Achilefu, S. Perspectives and potential applications of nanomedicine in breast and prostate cancer. Med. Res. Rev., 2013, 33(1), 3-32.
[http://dx.doi.org/10.1002/med.20233] [PMID: 23239045]
[49]
Hare, J.I.; Lammers, T.; Ashford, M.B.; Puri, S.; Storm, G.; Barry, S.T. Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. Adv. Drug Deliv. Rev., 2017, 108, 25-38.
[http://dx.doi.org/10.1016/j.addr.2016.04.025] [PMID: 27137110]
[50]
Zhang, R.X.; Wong, H.L.; Xue, H.Y.; Eoh, J.Y.; Wu, X.Y. Nanomedicine of synergistic drug combinations for cancer therapy - Strategies and perspectives. J. Control. Release, 2016, 240, 489-503.
[http://dx.doi.org/10.1016/j.jconrel.2016.06.012] [PMID: 27287891]
[51]
Lee, J.J.; Saiful Yazan, L.; Che Abdullah, C.A. A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment. Int. J. Nanomedicine, 2017, 12, 2373-2384.
[http://dx.doi.org/10.2147/IJN.S127329] [PMID: 28392694]
[52]
Suk, J.S.; Xu, Q.; Kim, N.; Hanes, J.; Ensign, L.M. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv. Drug Deliv. Rev.,, 2016, 99(pt a), 28-51.
[http://dx.doi.org/10.1016/j.addr.2015.09.012] [PMID: 26456916]
[53]
Wolinsky, J.B.; Colson, Y.L.; Grinstaff, M.W. Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. J. Control. Release, 2012, 159(1), 14-26.
[http://dx.doi.org/10.1016/j.jconrel.2011.11.031] [PMID: 22154931]
[54]
Contreras-Cáceres, R.; Cabeza, L.; Perazzoli, G.; Díaz, A.; López-Romero, J.M.; Melguizo, C.; Prados, J. Electrospun nanofibers: Recent applications in drug delivery and cancer therapy. Nanomaterials (Basel), 2019, 9(4), E656.
[http://dx.doi.org/10.3390/nano9040656] [PMID: 31022935]
[55]
Marty, M.; Cognetti, F.; Maraninchi, D.; Snyder, R.; Mauriac, L.; Tubiana-Hulin, M.; Chan, S.; Grimes, D.; Antón, A.; Lluch, A.; Kennedy, J.; O’Byrne, K.; Conte, P.; Green, M.; Ward, C.; Mayne, K.; Extra, J.M. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J. Clin. Oncol., 2005, 23(19), 4265-4274.
[http://dx.doi.org/10.1200/JCO.2005.04.173] [PMID: 15911866]
[56]
Narayanaswamy, R.; Torchilin, V.P. hydrogels and their applications in targeted drug delivery. Molecules, 2019, 24(3), 603.
[http://dx.doi.org/10.3390/molecules24030603] [PMID: 30744011]
[57]
Han, H.D.; Mora, E.M.; Roh, J.W.; Nishimura, M.; Lee, S.J.; Stone, R.L.; Bar-Eli, M.; Lopez-Berestein, G.; Sood, A.K. Chitosan hydrogel for localized gene silencing. Cancer Biol. Ther., 2011, 11(9), 839-845.
[http://dx.doi.org/10.4161/cbt.11.9.15185] [PMID: 21358280]
[58]
Segovia, N.; Pont, M.; Oliva, N.; Ramos, V.; Borrós, S.; Artzi, N. Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer. Adv. Healthc. Mater., 2015, 4(2), 271-280.
[http://dx.doi.org/10.1002/adhm.201400235] [PMID: 25113263]
[59]
Chen, X.; Li, Q.W.; Wang, X.M. Gold nanostructures for bioimaging, drug delivery and therapeutics. InPrecious Metals for Biomedical Applications; , 2014.
[60]
Jain, S.; Hirst, D.G.; O’Sullivan, J.M. Gold nanoparticles as novel agents for cancer therapy. Br. J. Radiol., 2012, 85(1010), 101-113.
[http://dx.doi.org/10.1259/bjr/59448833] [PMID: 22010024]
[61]
Li, J.L.; Wang, L.; Liu, X.Y.; Zhang, Z.P.; Guo, H.C.; Liu, W.M.; Tang, S.H. In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Lett., 2009, 274(2), 319-326.
[http://dx.doi.org/10.1016/j.canlet.2008.09.024] [PMID: 18977071]
[62]
Eissa, S.; Azzazy, H.M.E.; Matboli, M.; Shawky, S.M.; Said, H.; Anous, F.A. The prognostic value of histidine-rich glycoprotein RNA in breast tissue using unmodified gold nanoparticles assay. Appl. Biochem. Biotechnol., 2014, 174(2), 751-761.
[http://dx.doi.org/10.1007/s12010-014-1085-x] [PMID: 25091325]
[63]
Bae, P.K.; Chung, B.H. Multiplexed detection of various breast cancer cells by perfluorocarbon/quantum dot nanoemulsions conjugated with antibodies. Nano Converg., 2014, 1(1), 23.
[http://dx.doi.org/10.1186/s40580-014-0023-5] [PMID: 28191403]
[64]
Nagavarma, B. V. N.; Yadav, H. K. S.; Ayaz, A.; Vasudha, L. S.; Shivakumar, H. G. Different techniques for preparation of polymericnanoparticles- A Review Asian J. Pharmaceut. Clin. Res.,, 2012.
[65]
Dhar, S.; Kolishetti, N.; Lippard, S.J.; Farokhzad, O.C. Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc. Natl. Acad. Sci. USA, 2011, 108(5), 1850-1855.
[http://dx.doi.org/10.1073/pnas.1011379108] [PMID: 21233423]
[66]
Lee, J.H.; Nan, A. Combination drug delivery approaches in metastatic breast cancer. J. Drug Deliv., 2012.2012915375
[http://dx.doi.org/10.1155/2012/915375] [PMID: 22619725]
[67]
Katiyar, S.S.; Muntimadugu, E.; Rafeeqi, T.A.; Domb, A.J.; Khan, W. Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. Drug Deliv., 2016, 23(7), 2608-2616.
[http://dx.doi.org/10.3109/10717544.2015.1039667] [PMID: 26036652]
[68]
Abou-El-Naga, A.M.; Mutawa, G.; El-Sherbiny, I.M.; Mousa, S.A. Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells. Int. J. Nanomedicine, 2018, 13, 8153-8164.
[http://dx.doi.org/10.2147/IJN.S182184] [PMID: 30555232]
[69]
Suri, S.; Mirza, M. A.; Anwer, M. K.; Alshetaili, A. S.; Alshahrani, S. M.; Ahmed, F. J.; Iqbal, Z. Development of NIPAAm-PEG acrylate polymeric nanoparticles for co-delivery of paclitaxel with ellagic acid for the treatment of breast cancer J. Polym. Eng, 2019.
[70]
Mishra, P.; Nayak, B.; Dey, R.K. PEGylation in anti-cancer therapy: An Overview. Asian J. Pharmaceut. Sci., 2016, 11(3), 337-348.
[71]
Kalepu, S.; Nekkanti, V. Insoluble drug delivery strategies: Review of recent advances and business prospects. Acta Pharm. Sin. B, 2015, 5(5), 442-453.
[http://dx.doi.org/10.1016/j.apsb.2015.07.003] [PMID: 26579474]
[72]
Kang, D.I.; Kang, H.K.; Gwak, H.S.; Han, H.K.; Lim, S.J. Liposome composition is important for retention of liposomal rhodamine in P-glycoprotein-overexpressing cancer cells. Drug Deliv., 2009, 16(5), 261-267.
[http://dx.doi.org/10.1080/10717540902937562] [PMID: 19538007]
[73]
Kullberg, M.; Owens, J.L.; Mann, K.; Listeriolysin, O. Listeriolysin O enhances cytoplasmic delivery by Her-2 targeting liposomes. J. Drug Target., 2010, 18(4), 313-320.
[http://dx.doi.org/10.3109/10611861003663549] [PMID: 20201742]
[74]
Wong, M.Y.; Chiu, G.N.C. Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. Anticancer Drugs, 2010, 21(4), 401-410.
[http://dx.doi.org/10.1097/CAD.0b013e328336e940] [PMID: 20110806]
[75]
Cosco, D.; Paolino, D.; Cilurzo, F.; Casale, F.; Fresta, M. Gemcitabine and tamoxifen-loaded liposomes as multidrug carriers for the treatment of breast cancer diseases. Int. J. Pharm., 2012, 422(1-2), 229-237.
[http://dx.doi.org/10.1016/j.ijpharm.2011.10.056] [PMID: 22093954]
[76]
Eloy, J.O.; Petrilli, R.; Topan, J.F.; Antonio, H.M.R.; Barcellos, J.P.A.; Chesca, D.L.; Serafini, L.N.; Tiezzi, D.G.; Lee, R.J.; Marchetti, J.M. Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy. Colloids Surf. B Biointerfaces, 2016, 141, 74-82.
[http://dx.doi.org/10.1016/j.colsurfb.2016.01.032] [PMID: 26836480]
[77]
Bai, F.; Yin, Y.; Chen, T.; Chen, J.; Ge, M.; Lu, Y.; Xie, F.; Zhang, J.; Wu, K.; Liu, Y. Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer. Int. J. Nanomedicine, 2018, 13, 1327-1339.
[http://dx.doi.org/10.2147/IJN.S150237] [PMID: 29563790]
[78]
Zhang, Y.; Huang, Y.; Li, S. Polymeric micelles: Nanocarriers for cancer-targeted drug delivery. AAPS PharmSciTech, 2014, 15(4), 862-871.
[http://dx.doi.org/10.1208/s12249-014-0113-z] [PMID: 24700296]
[79]
Yuan, Y.; Cai, T.; Xia, X.; Zhang, R.; Chiba, P.; Cai, Y. Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer. Drug Deliv., 2016, 23(9), 3350-3357.
[http://dx.doi.org/10.1080/10717544.2016.1178825] [PMID: 27098896]
[80]
Lee, A.L.Z.; Wang, Y.; Cheng, H.Y.; Pervaiz, S.; Yang, Y.Y. The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles. Biomaterials, 2009, 30(5), 919-927.
[http://dx.doi.org/10.1016/j.biomaterials.2008.10.062] [PMID: 19042015]
[81]
Xiang, J.; Wu, B.; Zhou, Z.; Hu, S.; Piao, Y.; Zhou, Q.; Wang, G.; Tang, J.; Liu, X.; Shen, Y. Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy. Sci. China Life Sci., 2018, 61(4), 436-447.
[http://dx.doi.org/10.1007/s11427-017-9274-9] [PMID: 29572777]
[82]
Zajdel, A.; Wilczok, A.; Jelonek, K.; Musiał-Kulik, M.; Foryś, A.; Li, S.; Kasperczyk, J. Cytotoxic effect of paclitaxel and lapatinib Co-Delivered in polylactide-co-poly(ethylene glycol) micelles on HER-2-negative breast cancer cells. Pharmaceutics, 2019, 11(4), 169.
[http://dx.doi.org/10.3390/pharmaceutics11040169] [PMID: 30959904]
[83]
Wan, X.; Beaudoin, J.J.; Vinod, N.; Min, Y.; Makita, N.; Bludau, H.; Jordan, R.; Wang, A.; Sokolsky, M.; Kabanov, A.V. Co-delivery of paclitaxel and cisplatin in poly(2-oxazoline) polymeric micelles: Implications for drug loading, release, pharmacokinetics and outcome of ovarian and breast cancer treatments. Biomaterials, 2019, 192, 1-14.
[http://dx.doi.org/10.1016/j.biomaterials.2018.10.032] [PMID: 30415101]
[84]
Madaan, K.; Kumar, S.; Poonia, N.; Lather, V.; Pandita, D. Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues. J. Pharm. Bioallied Sci., 2014, 6(3), 139-150.
[http://dx.doi.org/10.4103/0975-7406.130965] [PMID: 25035633]
[85]
Wolinsky, J.B.; Grinstaff, M.W. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Adv. Drug Deliv. Rev., 2008, 60(9), 1037-1055.
[http://dx.doi.org/10.1016/j.addr.2008.02.012] [PMID: 18448187]
[86]
Kulhari, H.; Pooja, D.; Shrivastava, S.; Kuncha, M.; Naidu, V.G.M.; Bansal, V.; Sistla, R.; Adams, D.J. Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer. Sci. Rep., 2016, 6, 23179.
[http://dx.doi.org/10.1038/srep23179] [PMID: 27052896]
[87]
Gu, Y.; Guo, Y.; Wang, C.; Xu, J.; Wu, J.; Kirk, T.B.; Ma, D.; Xue, W. A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery. Mater. Sci. Eng. C, 2017, 70(Pt 1), 572-585.
[http://dx.doi.org/10.1016/j.msec.2016.09.035] [PMID: 27770930]
[88]
Torres-Pérez, S.A.; Ramos-Godínez, M.D.P.; Ramón-Gallegos, E. Effect of methotrexate conjugated PAMAM dendrimers on the viability of breast cancer cells. InAIP Conference Proceedings; , 2019.
[http://dx.doi.org/10.1063/1.5095929]
[89]
Mydin, R.B.S.M.N.; Moshawih, S. Nanoparticles in nanomedicine application: Lipid-based nanoparticles and their safety concerns. Nanotechnology: Applications in Energy, Drug and Food; Springer, 2019, pp. 227-232.
[http://dx.doi.org/10.1007/978-3-319-99602-8_10]
[90]
Rajabi, M.; Mousa, S.A. lipid nanoparticles and their application in nanomedicine. Curr. Pharm. Biotechnol., 2016, 17(8), 662-672.
[http://dx.doi.org/10.2174/1389201017666160415155457] [PMID: 27087491]
[91]
Wang, W.; Zhang, L.; Chen, T.; Guo, W.; Bao, X.; Wang, D.; Ren, B.; Wang, H.; Li, Y.; Wang, Y.; Chen, S.; Tang, B.; Yang, Q.; Chen, C. anticancer effects of resveratrol-loaded solid lipid nanoparticles on human breast cancer cells. Molecules, 2017, 22(11), 1814.
[http://dx.doi.org/10.3390/molecules22111814] [PMID: 29068422]
[92]
Naguib, Y.W.; Rodriguez, B.L.; Li, X.; Hursting, S.D.; Williams, R.O.; Cui, Z. Solid lipid nanoparticle formulations of docetaxel prepared with high melting point triglycerides: In Vitro and in Vivo evaluation; Mol. Pharm, 2014.
[93]
Guney Eskiler, G.; Cecener, G.; Dikmen, G.; Egeli, U.; Tunca, B. Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer. Eur. J. Pharm. Sci., 2018, 120, 73-88.
[http://dx.doi.org/10.1016/j.ejps.2018.04.040] [PMID: 29719240]
[94]
Zheng, G.; Zheng, M.; Yang, B.; Fu, H.; Li, Y. Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo. Biomed. Pharmacother., 2019.116109006
[http://dx.doi.org/10.1016/j.biopha.2019.109006] [PMID: 31152925]
[95]
García-Pinel, B.; Porras-Alcalá, C.; Ortega-Rodríguez, A.; Sarabia, F.; Prados, J.; Melguizo, C.; López-Romero, J.M. lipid-based nanoparticles: application and recent advances in cancer treatment. Nanomaterials (Basel), 2019, 9(4), 638.
[http://dx.doi.org/10.3390/nano9040638] [PMID: 31010180]
[96]
Sabzichi, M.; Mohammadian, J.; Yari Khosroushahi, A.; Bazzaz, R.; Hamishehkar, H. Folate-targeted nanostructured lipid carriers (NLCs) enhance (Letrozol) efficacy in MCF-7 breast cancer cells. Asian Pac. J. Cancer Prev., 2016, 17(12), 5185-5188.
[PMID: 28124885]
[97]
Li, X.; Jia, X.; Niu, H. Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy. Int. J. Nanomedicine, 2018, 13, 4107-4119.
[http://dx.doi.org/10.2147/IJN.S163929] [PMID: 30034236]
[98]
Rezazadeh, M.; Emami, J.; Hassanzadeh, F.; Sadeghi, H.; Rostami, M.; Mohammadkhani, H. Targeted nanostructured lipid carriers for delivery of paclitaxel to cancer cells: preparation, characterization, and cell toxicity. Curr. Drug Deliv., 2017, 14(8), 1189-1200.
[http://dx.doi.org/10.2174/1567201814666170503143646] [PMID: 28472908]
[99]
Beh, C.Y.; Rasedee, A.; Selvarajah, G.T.; Yazan, L.S.; Omar, A.R.; Foong, J.N.; How, C.W.; Foo, J.B. Enhanced anti-mammary gland cancer activities of tamoxifen-loaded erythropoietin-coated drug delivery system. PLoS One, 2019, 14(7), e0219285.
[http://dx.doi.org/10.1371/journal.pone.0219285] [PMID: 31291309]
[100]
Swenson, C.E.; Perkins, W.R.; Roberts, P.; Janoff, A.S. Liposome technology and the development of myocetTM (Liposomal Doxorubicin Citrate). Breast, 2001.
[http://dx.doi.org/10.1016/S0960-9776(01)80001-1]
[101]
O’Brien, M.E.R.; Wigler, N.; Inbar, M.; Rosso, R.; Grischke, E.; Santoro, A.; Catane, R.; Kieback, D.G.; Tomczak, P.; Ackland, S.P.; Orlandi, F.; Mellars, L.; Alland, L.; Tendler, C. CAELYX Breast Cancer Study Group Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann. Oncol., 2004, 15(3), 440-449.
[http://dx.doi.org/10.1093/annonc/mdh097] [PMID: 14998846]
[102]
Hamaguchi, T.; Matsumura, Y.; Suzuki, M.; Shimizu, K.; Goda, R.; Nakamura, I.; Nakatomi, I.; Yokoyama, M.; Kataoka, K.; Kakizoe, T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer, 2005, 92(7), 1240-1246.
[http://dx.doi.org/10.1038/sj.bjc.6602479] [PMID: 15785749]
[103]
Singer, J.W.; Shaffer, S.; Baker, B.; Bernareggi, A.; Stromatt, S.; Nienstedt, D.; Besman, M. Paclitaxel poliglumex (XYOTAX; CT-2103): An intracellularly targeted taxane. Anticancer Drugs, 2005, 16(3), 243-254.
[http://dx.doi.org/10.1097/00001813-200503000-00003] [PMID: 15711176]
[104]
Boulikas, T. Clinical overview on Lipoplatin: A successful liposomal formulation of cisplatin. Expert Opin. Investig. Drugs, 2009, 18(8), 1197-1218.
[http://dx.doi.org/10.1517/13543780903114168] [PMID: 19604121]
[105]
Zhao, M.; Lei, C.; Yang, Y.; Bu, X.; Ma, H.; Gong, H.; Liu, J.; Fang, X.; Hu, Z.; Fang, Q. Abraxane, the nanoparticle formulation of paclitaxel can induce drug resistance by up-regulation of P-gp. PLoS One, 2015, 10(7), e0131429.
[http://dx.doi.org/10.1371/journal.pone.0131429] [PMID: 26182353]
[106]
Adkins, C.E.; Nounou, M.I.; Hye, T.; Mohammad, A.S.; Terrell-Hall, T.; Mohan, N.K.; Eldon, M.A.; Hoch, U.; Lockman, P.R. NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer. BMC Cancer, 2015, 15, 685.
[http://dx.doi.org/10.1186/s12885-015-1672-4] [PMID: 26463521]
[107]
Swenson, C.E.; Haemmerich, D.; Maul, D.H.; Knox, B.; Ehrhart, N.; Reed, R.A. increased duration of heating boosts local drug deposition during radiofrequency ablation in combination with thermally sensitive liposomes (ThermoDox) in a porcine model. PLoS One, 2015, 10(10), e0139752.
[http://dx.doi.org/10.1371/journal.pone.0139752] [PMID: 26431204]
[108]
He, Z.; Wan, X.; Schulz, A.; Bludau, H.; Dobrovolskaia, M.A.; Stern, S.T.; Montgomery, S.A.; Yuan, H.; Li, Z.; Alakhova, D.; Sokolsky, M.; Darr, D.B.; Perou, C.M.; Jordan, R.; Luxenhofer, R.; Kabanov, A.V. A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity. Biomaterials, 2016, 101, 296-309.
[http://dx.doi.org/10.1016/j.biomaterials.2016.06.002] [PMID: 27315213]
[109]
Bulbake, U.; Doppalapudi, S.; Kommineni, N.; Khan, W. Liposomal formulations in clinical use: An updated review. Pharmaceutics, 2017, 9(2), E12.
[http://dx.doi.org/10.3390/pharmaceutics9020012] [PMID: 28346375]
[110]
Burade, V.; Bhowmick, S.; Maiti, K.; Zalawadia, R.; Ruan, H.; Thennati, R. Lipodox® (generic doxorubicin hydrochloride liposome injection): in vivo efficacy and bioequivalence versus Caelyx® (doxorubicin hydrochloride liposome injection) in human mammary carcinoma (MX-1) xenograft and syngeneic fibrosarcoma (WEHI 164) mouse models. BMC Cancer, 2017, 17(1), 405.
[http://dx.doi.org/10.1186/s12885-017-3377-3] [PMID: 28587612]
[111]
Huang, S.T.; Wang, Y.P.; Chen, Y.H.; Lin, C.T.; Li, W.S.; Wu, H.C. Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol. Int. J. Oncol., 2018, 53(3), 1105-1117.
[http://dx.doi.org/10.3892/ijo.2018.4449] [PMID: 29956746]
[112]
Do, V.Q.; Park, K.H.; Park, J.M.; Lee, M.Y. Comparative in vitro toxicity study of docetaxel and nanoxel, a docetaxel-loaded micellar formulation using cultured and blood cells. Toxicol. Res., 2019, 35(2), 201-207.
[http://dx.doi.org/10.5487/TR.2019.35.2.201] [PMID: 31015902]
[113]
Lee, E.; Moon, A. Identification of biomarkers for breast cancer using databases. J. Cancer Prev., 2016, 21(4), 235-242.
[http://dx.doi.org/10.15430/JCP.2016.21.4.235] [PMID: 28053957]

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