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Review Article

抗VEGF治疗角膜疾病

卷 21, 期 12, 2020

页: [1159 - 1180] 页: 22

弟呕挨: 10.2174/1389450121666200319111710

价格: $65

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摘要

背景：角膜新生血管(CN)是眼部不同病理条件的一个线索特征，可导致角膜水肿和混浊，进而导致视力丧失。血管内皮生长因子(VEGF)在新血管的形成、增殖和迁移中起关键作用，在这些条件下被发现上调。如今，使用不同途径的抗VEGF药物可以下调血管生成过程。 目的：评价抗VEGF药物治疗不同病因的CNV的疗效、安全性和可能的未来发展方向。 方法： 结果：使用抗VEGF治疗CN可降低病理性血管密度，且无明显副作用。各种给药途径，如局部给药、结膜下给药和星状细胞内给药，其选择取决于病人和疾病的特点。如果在成熟和牢固的船只出现之前进行早期管理，会取得更大的效果。对于新生血管复发风险较高的病例，如缺血性和炎症刺激不能完全逆转的慢性长期疾病，应采用包括抗vegf制剂在内的多种药物的联合治疗。 结论：抗VEGF药物的有效性和安全性支持它们被应用到CN的日常临床实践中。

关键词: 抗VEGF ，新生血管，角膜，贝伐珠单抗，安维汀，雷尼珠单抗，角膜新生血管形成，血管内皮生长因子

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