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摘要
背景:角膜新生血管(CN)是眼部不同病理条件的一个线索特征,可导致角膜水肿和混浊,进而导致视力丧失。血管内皮生长因子(VEGF)在新血管的形成、增殖和迁移中起关键作用,在这些条件下被发现上调。如今,使用不同途径的抗VEGF药物可以下调血管生成过程。 目的:评价抗VEGF药物治疗不同病因的CNV的疗效、安全性和可能的未来发展方向。 方法: 结果:使用抗VEGF治疗CN可降低病理性血管密度,且无明显副作用。各种给药途径,如局部给药、结膜下给药和星状细胞内给药,其选择取决于病人和疾病的特点。如果在成熟和牢固的船只出现之前进行早期管理,会取得更大的效果。对于新生血管复发风险较高的病例,如缺血性和炎症刺激不能完全逆转的慢性长期疾病,应采用包括抗vegf制剂在内的多种药物的联合治疗。 结论:抗VEGF药物的有效性和安全性支持它们被应用到CN的日常临床实践中。
关键词: 抗VEGF ,新生血管,角膜,贝伐珠单抗,安维汀,雷尼珠单抗,角膜新生血管形成,血管内皮生长因子
[http://dx.doi.org/10.1016/j.preteyeres.2006.09.002] [PMID: 17074526]
[http://dx.doi.org/10.1016/j.preteyeres.2006.09.001] [PMID: 17079182]
[http://dx.doi.org/10.1007/s00417-019-04301-6] [PMID: 30944986]
[http://dx.doi.org/10.1001/jamaophthalmol.2017.3204] [PMID: 28880979]
[http://dx.doi.org/10.1097/ICO.0000000000000198] [PMID: 25090164]
[http://dx.doi.org/10.1016/j.jtos.2018.06.004] [PMID: 29908870]
[http://dx.doi.org/10.1016/S0039-6257(98)00035-6] [PMID: 9862312]
[http://dx.doi.org/10.1080/08820530902802013] [PMID: 19437350]
[http://dx.doi.org/10.5483/BMBRep.2013.46.4.193] [PMID: 23615260]
[http://dx.doi.org/10.1038/emm.2006.21] [PMID: 16672771]
[http://dx.doi.org/10.1001/archopht.1992.01080150103037] [PMID: 1543461]
[http://dx.doi.org/10.2174/187221309789257450] [PMID: 19702562]
[PMID: 9430540]
[http://dx.doi.org/10.1001/archopht.1996.01100140172010] [PMID: 8694732]
[PMID: 16935211]
[http://dx.doi.org/10.1136/bjo.2007.132597] [PMID: 18614570]
[http://dx.doi.org/10.1097/ICO.0b013e31821dd986] [PMID: 22030600]
[http://dx.doi.org/10.1016/S1542-0124(11)70035-0] [PMID: 22023817]
[http://dx.doi.org/10.1172/JCI20465] [PMID: 15057311]
[http://dx.doi.org/10.1002/jlb.55.3.410] [PMID: 7509844]
[http://dx.doi.org/10.1006/exer.1999.0790] [PMID: 10865990]
[http://dx.doi.org/10.2353/ajpath.2007.070172] [PMID: 17690185]
[http://dx.doi.org/10.1016/j.exer.2005.05.001] [PMID: 16009363]
[PMID: 1281615]
[http://dx.doi.org/10.4049/jimmunol.1003239] [PMID: 21325621]
[PMID: 10937562]
[http://dx.doi.org/10.1016/j.jcjo.2017.03.017] [PMID: 29217022]
[PMID: 9864271]
[http://dx.doi.org/10.1167/iovs.11-8379] [PMID: 23307967]
[http://dx.doi.org/10.1111/j.1442-9071.2007.01572.x] [PMID: 17997779]
[http://dx.doi.org/10.1167/iovs.16-19420] [PMID: 27327585]
[http://dx.doi.org/10.1096/fasebj.13.1.9] [PMID: 9872925]
[http://dx.doi.org/10.1093/jb/mvs136] [PMID: 23172303]
[http://dx.doi.org/10.2174/138955709788922665] [PMID: 19689408]
[http://dx.doi.org/10.1046/j.1523-1755.2000.07718.x] [PMID: 10997700]
[PMID: 7538264]
[PMID: 8449682]
[http://dx.doi.org/10.1167/iovs.05-1071] [PMID: 16639000]
[PMID: 1689281]
[http://dx.doi.org/10.1016/S0065-230X(08)61024-6] [PMID: 10547669]
[http://dx.doi.org/10.1172/JCI119868] [PMID: 9399960]
[http://dx.doi.org/10.1096/fj.09-145102] [PMID: 20400538]
[http://dx.doi.org/10.1161/ATVBAHA.114.304627] [PMID: 25657312]
[http://dx.doi.org/10.1097/ICO.0b013e3182781ea4] [PMID: 23328697]
[http://dx.doi.org/10.1016/j.ajo.2005.05.020] [PMID: 16310478]
[http://dx.doi.org/10.1016/j.exer.2016.04.016] [PMID: 27181227]
[http://dx.doi.org/10.1097/ICO.0000000000000336] [PMID: 25651492]
[http://dx.doi.org/10.1016/S0161-6420(92)31996-7] [PMID: 1553204]
[http://dx.doi.org/10.1136/bjo.2003.035071] [PMID: 15148229]
[http://dx.doi.org/10.1111/j.1600-0420.2007.01049.x] [PMID: 17995975]
[http://dx.doi.org/10.1111/j.1755-3768.2008.01399.x] [PMID: 19021596]
[http://dx.doi.org/10.5114/ceji.2016.63132] [PMID: 27833450]
[http://dx.doi.org/10.1097/ICU.0b013e3282f0ca54] [PMID: 18163003]
[http://dx.doi.org/10.1155/2012/852183] [PMID: 22132316]
[http://dx.doi.org/10.1016/j.survophthal.2012.01.007] [PMID: 22898649]
[http://dx.doi.org/10.1517/14712598.2012.721772] [PMID: 22963411]
[PMID: 25914729]
[http://dx.doi.org/10.1177/1947601911423031] [PMID: 22866201]
[PMID: 23725500]
[http://dx.doi.org/10.1159/000431199] [PMID: 26502311]
[http://dx.doi.org/10.1038/eye.2014.13] [PMID: 24525867]
[http://dx.doi.org/10.3341/kjo.2014.28.2.177] [PMID: 24688262]
[http://dx.doi.org/10.1016/j.jtos.2012.01.005] [PMID: 22482468]
[http://dx.doi.org/10.1136/bjo.2007.134874] [PMID: 18356264]
[http://dx.doi.org/10.1186/1472-6750-14-17] [PMID: 24575750]
[http://dx.doi.org/10.1182/blood-2012-08-453043] [PMID: 23476047]
[http://dx.doi.org/10.1097/ICO.0b013e318206c893] [PMID: 21975440]
[http://dx.doi.org/10.1167/iovs.12-10408] [PMID: 23150613]
[http://dx.doi.org/10.1167/iovs.06-0853] [PMID: 17460257]
[http://dx.doi.org/10.1101/cshperspect.a006411] [PMID: 22675660]
[http://dx.doi.org/10.1002/jcp.22251] [PMID: 20506173]
[http://dx.doi.org/10.1002/bies.201200086] [PMID: 23129317]
[http://dx.doi.org/10.1097/ICO.0b013e31822480f9] [PMID: 22157572]
[http://dx.doi.org/10.4103/0974-620X.116624] [PMID: 24082664]
[http://dx.doi.org/10.1136/bjo.2006.107912] [PMID: 17179168]
[http://dx.doi.org/10.1590/S0001-37652007000300004] [PMID: 17768531]
[http://dx.doi.org/10.1080/02713680802607740] [PMID: 19219678]
[http://dx.doi.org/10.1016/j.burns.2012.07.018] [PMID: 22922008]
[http://dx.doi.org/10.1001/archopht.125.6.834] [PMID: 17562998]
[http://dx.doi.org/10.1097/ICO.0b013e318159019f] [PMID: 18216566]
[http://dx.doi.org/10.1016/j.ophtha.2005.11.019] [PMID: 16458968]
[http://dx.doi.org/10.1136/bjo.2005.066431] [PMID: 16170134]
[http://dx.doi.org/10.1016/j.ophtha.2005.01.043] [PMID: 15885778]
[http://dx.doi.org/10.1007/s00417-007-0684-4] [PMID: 17934753]
[http://dx.doi.org/10.1097/01.ico.0000157400.81408.2b] [PMID: 16160501]
[http://dx.doi.org/10.1080/092739490500363] [PMID: 15621867]
[http://dx.doi.org/10.2147/OPTH.S1858] [PMID: 19668737]
[http://dx.doi.org/10.1016/S0002-9440(10)61777-4] [PMID: 11549594]
[http://dx.doi.org/10.1097/ICO.0b013e31823f8d71] [PMID: 22357391]
[http://dx.doi.org/10.1136/bjophthalmol-2012-302137] [PMID: 23087419]
[http://dx.doi.org/10.1097/01.ico.0000611440.32234.8f] [PMID: 18580272]
[http://dx.doi.org/10.1097/ICO.0b013e3181dc81a0] [PMID: 20861729]
[http://dx.doi.org/10.1007/s00417-009-1099-1] [PMID: 19415316]
[http://dx.doi.org/10.1097/ICO.0b013e31821379aa] [PMID: 21673570]
[PMID: 1412962]
[http://dx.doi.org/10.1001/archopht.121.8.1087] [PMID: 12912684]
[http://dx.doi.org/10.1016/j.ophtha.2006.12.012] [PMID: 17367863]
[http://dx.doi.org/10.1167/iovs.06-0570] [PMID: 17525183]
[PMID: 12091407]
[http://dx.doi.org/10.1007/s00417-014-2626-2] [PMID: 24728466]
[http://dx.doi.org/10.1089/jop.2015.0007] [PMID: 26172526]
[http://dx.doi.org/10.1016/j.survophthal.2014.06.001] [PMID: 25444520]
[http://dx.doi.org/10.1016/j.ophtha.2007.05.016] [PMID: 17908597]
[http://dx.doi.org/10.1007/s00417-007-0587-4] [PMID: 17458556]
[http://dx.doi.org/10.1016/j.jcrs.2007.07.012] [PMID: 17964413]
[http://dx.doi.org/10.1615/CritRevImmunol.v18.i4.20] [PMID: 9704192]
[http://dx.doi.org/10.1007/s10792-014-9938-4] [PMID: 24715230]
[http://dx.doi.org/10.1097/ICO.0b013e3180318107] [PMID: 17457206]
[http://dx.doi.org/10.1097/ICO.0b013e31820ca19e] [PMID: 22146545]
[http://dx.doi.org/10.1097/ICO.0b013e3181e291a6] [PMID: 20885312]
[http://dx.doi.org/10.1177/112067210901900530] [PMID: 19787612]
[http://dx.doi.org/10.1016/j.ajo.2016.03.020] [PMID: 27018234]
[http://dx.doi.org/10.1167/iovs.03-0940] [PMID: 15037577]
[http://dx.doi.org/10.1001/archopht.1983.01040010640024] [PMID: 6188447]
[http://dx.doi.org/10.1001/archopht.120.8.1063] [PMID: 12149060]
[http://dx.doi.org/10.1001/archopht.1989.01070020575043] [PMID: 2478111]
[PMID: 10892856]
[http://dx.doi.org/10.1097/ICO.0b013e31817c41e3] [PMID: 18812781]
[http://dx.doi.org/10.1097/ICO.0b013e318158f6ad] [PMID: 18245970]
[http://dx.doi.org/10.1016/j.jaapos.2011.12.153] [PMID: 22459106]
[http://dx.doi.org/10.1007/s10792-017-0786-x] [PMID: 29256167]
[http://dx.doi.org/10.1089/jop.2009.0022] [PMID: 20148650]
[http://dx.doi.org/10.1016/j.ophtha.2007.01.017] [PMID: 17467524]
[http://dx.doi.org/10.1038/sj.eye.6701811] [PMID: 15746957]
[http://dx.doi.org/10.1155/2018/2602487] [PMID: 29967706]
[http://dx.doi.org/10.1097/ICO.0000000000000419] [PMID: 25811720]
[http://dx.doi.org/10.1007/s12026-019-09087-7] [PMID: 31327149]
[http://dx.doi.org/10.1016/j.jtos.2017.05.008] [PMID: 28736335]
[http://dx.doi.org/10.3109/09273941003721926] [PMID: 20482396]
[http://dx.doi.org/10.1167/iovs.04-0299] [PMID: 15557436]
[http://dx.doi.org/10.1155/2008/129873] [PMID: 19223981]
[http://dx.doi.org/10.1038/nm0603-669] [PMID: 12778165]
[PMID: 26109847]
[http://dx.doi.org/10.2147/DDDT.S146556] [PMID: 29805249]
[http://dx.doi.org/10.1076/ceyr.23.1.1.5422] [PMID: 11821980]
[http://dx.doi.org/10.1111/j.1755-3768.2009.01585.x] [PMID: 19519730]
[http://dx.doi.org/10.1089/jop.2010.0094] [PMID: 20977367]
[http://dx.doi.org/10.1159/000252980] [PMID: 19887878]
[http://dx.doi.org/10.1080/08820530902801106] [PMID: 19437347]
[http://dx.doi.org/10.1076/ceyr.25.1.17.9959] [PMID: 12518239]
[http://dx.doi.org/10.1097/00003226-200307000-00015] [PMID: 12827055]
[http://dx.doi.org/10.1097/00003226-200110000-00013] [PMID: 11588427]
[http://dx.doi.org/10.1080/02713680701799101] [PMID: 18214740]
[http://dx.doi.org/10.1111/ceo.12140] [PMID: 23777441]
[http://dx.doi.org/10.1007/s00417-007-0660-z] [PMID: 17674014]
[PMID: 23486999]
[http://dx.doi.org/10.1016/j.ophtha.2008.02.013] [PMID: 18439681]
[http://dx.doi.org/10.1097/ICO.0b013e3182775f8d] [PMID: 23407316]
[http://dx.doi.org/10.1001/archophthalmol.2009.18] [PMID: 19365012]
[http://dx.doi.org/10.1167/iovs.08-1997] [PMID: 18997093]
[http://dx.doi.org/10.1097/ICO.0b013e318180e50f] [PMID: 19034142]
[http://dx.doi.org/10.1097/ICO.0b013e31817786ad] [PMID: 18812760]
[http://dx.doi.org/10.1167/iovs.09-3745] [PMID: 19892863]
[http://dx.doi.org/10.1111/j.1442-9071.2009.02112.x] [PMID: 19788671]
[PMID: 25410169]
[http://dx.doi.org/10.1167/iovs.14-15257] [PMID: 25212779]
[http://dx.doi.org/10.1590/S0004-27492012000400012] [PMID: 23258661]
[http://dx.doi.org/10.1097/00006982-200603000-00002] [PMID: 16508424]
[http://dx.doi.org/10.1167/iovs.06-0433] [PMID: 17003454]
[http://dx.doi.org/10.1136/bjo.2006.099598] [PMID: 16854824]
[http://dx.doi.org/10.1097/ICO.0b013e3181ba0ae2] [PMID: 20458243]
[http://dx.doi.org/10.1111/j.1600-0420.1997.tb00623.x] [PMID: 9527324]
[http://dx.doi.org/10.1167/iovs.07-1418] [PMID: 18487369]
[http://dx.doi.org/10.1097/ICO.0000000000001871] [PMID: 30933961]
[http://dx.doi.org/10.2353/ajpath.2007.061237] [PMID: 17591953]
[http://dx.doi.org/10.1007/s00347-007-1569-y] [PMID: 17653724]
[http://dx.doi.org/10.1007/s10792-013-9807-6] [PMID: 23722674]
[http://dx.doi.org/10.1016/j.survophthal.2010.08.006] [PMID: 21335144]
[http://dx.doi.org/10.1001/jama.293.12.1509] [PMID: 15784876]
[http://dx.doi.org/10.2353/ajpath.2006.050588] [PMID: 16723717]
[http://dx.doi.org/10.1016/j.ajo.2010.04.024] [PMID: 20591397]
[http://dx.doi.org/10.1080/02713683.2017.1416146] [PMID: 29265937]
[http://dx.doi.org/10.1167/iovs.04-0128] [PMID: 15326102]
[http://dx.doi.org/10.1097/ICO.0b013e3182542613] [PMID: 22668582]
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