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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

颅内动脉粥样硬化狭窄与中风后认知障碍有关：较小中风的横断面研究

卷 17, 期 2, 2020

页: [177 - 184] 页: 8

弟呕挨: 10.2174/1567205017666200303141920

价格: $65

摘要

背景：颅内动脉粥样硬化狭窄（ICAS）是认知障碍的重要危险因素。然而，尚不清楚ICAS患者在急性，非致残性缺血性中风（轻度中风）后是否更有可能出现认知障碍。 目的：我们旨在研究ICAS与卒中后认知障碍之间的关系。 方法：在这项横断面研究中，急性，非致残性缺血性中风患者在中风后两周内接受了两次认知测试和ICAS影像学评估。为了确定ICAS与中风后认知障碍之间的关联，我们进行了多因素logistic回归分析，该分析针对多种人口统计学和血管危险因素进行了调整。 结果：在本研究的164例轻度中风患者中，有98例（59.76％）被诊断为中风后认知障碍（蒙特利尔认知评估得分<26）。调整了潜在的混杂因素后，我们发现，与没有ICAS的患者相比，ICAS的患者在发生急性，非致残性缺血性卒中后更容易出现认知功能障碍（几率：2.13； 95％的置信区间：1.07-4.26），在视觉空间和执行功能的测试中表现不佳。 结论：在这项对中风较轻的人群的横断面研究中，我们的发现表明，ICAS与中风后认知障碍之间存在正相关。

关键词: 轻度中风，颅内狭窄，中风后认知障碍，血管性认知障碍，痴呆，横断面研究。

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