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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

淀粉样β诱导的阿尔茨海默氏病转基因小鼠模型的肠系膜炎症

卷 17, 期 1, 2020

页: [52 - 59] 页: 8

弟呕挨: 10.2174/1567205017666200212160343

价格: $65

摘要

背景：阿尔茨海默氏病（AD）是一种神经退行性疾病，其组织病理学特征是淀粉样β（Aβ）肽的积累和活化的小胶质细胞相关的炎症。这些特征在AD模型小鼠的中枢神经系统中得到了很好的研究。但是，尚未对这些小鼠的周围炎症进行深入研究。 目的：我们评估了AD模型小鼠外周淋巴组织的炎症反应，尤其是髓样树突状细胞（mDC），以确定它们与Aβ沉积的关系。 方法：我们收集了5只FAD转基因小鼠的肠系膜淋巴结（MLN）和Peyer斑（PPs）的淋巴细胞作为AD模型。使用流式细胞仪分析淋巴细胞以表征mDC和T细胞。离体用Aβ1-42处理收集的淋巴细胞以评估炎症反应。 结果：我们观察到在MLN和PP的mDC中，炎症细胞因子和趋化因子（包括白介素（IL）-12和巨噬细胞炎症蛋白-1α）的水平升高，并且编程性死亡配体1（一种免疫抑制共刺激分子）水平降低。 5×FAD小鼠的mDC表面。此外，我们发现在5xFAD小鼠中，MLNs中产生干扰素（IFN）-γ的CD4或CD8阳性T细胞增加。此外，用Aβ肽进行离体治疗可增加5xFAD小鼠淋巴细胞产生的IL-12和IFN-γ。 结论：本研究表明，在5×FAD小鼠的MLN和PP中诱导了促炎性mDC和T细胞。

关键词: 阿尔茨海默氏病，β淀粉样蛋白，肠系膜淋巴结，髓样树突状细胞，派尔贴片，T细胞。

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