Login Register Cart 0
Research Article

华南地区RXRG单核苷酸多态性与2型糖尿病遗传易感性的关系

卷 20, 期 6, 2020

页: [408 - 414] 页: 7

弟呕挨: 10.2174/1566524020666191206163951

价格: $65

摘要

目的：探讨中国南方汉族人群RXRG rs1467664，rs3753898基因多态性与2型糖尿病遗传易感性的关系。 方法：在我们的病例对照研究中，使用SNPscanTM试剂盒对1092例T2D患者和1092例正常人作为单核苷酸多态性（SNP）rs1467664和rs3753898进行基因分型。用SPSS 20.0软件分析两组的基因型和等位基因频率分布。 结果：RXRG rs3753898的基因型和等位基因的分布在两组之间具有统计学意义，但rs1467664的基因型和等位基因的分布没有显着差异。两组在年龄，性别和体重指数调整前后，rs3753898在加性，显性和隐性模型下均具有统计学意义（P <0.05），但在显性和共显性遗传模型下均未发现统计学差异（P <0.05）。 P> 0.05）。 rs1467664的遗传模型在两组之间没有显着差异（P> 0.05）。由rs1467664等位基因T和rs3753898等位基因A组成的单倍型是T2D的高风险因素，OR = 1.27，95％CI（1.09-1.47），Padj = 0.002。 结论：我们的结果表明，RXRG rs3753898的单核苷酸多态性可能与2型糖尿病的遗传易感性有关。由rs1467664的等位基因T和rs3753898的等位基因A组成的单倍型是2型糖尿病的危险因素，这表明RXRG基因的遗传变异可能是中国汉族人群糖尿病的遗传原因。

关键词: 2型糖尿病（T2D），单核苷酸多态性（SNP），类维生素X受体伽马（RXRG），中国汉族人群。

« Previous Next »
[1]
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010; 87(1): 4-14.
[http://dx.doi.org/10.1016/j.diabres.2009.10.007] [PMID: 19896746]
[2]
Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94(3): 311-21.
[http://dx.doi.org/10.1016/j.diabres.2011.10.029] [PMID: 22079683]
[3]
Zinman B. The international diabetes federation world diabetes congress. Eur Endocrinol 2015; 11(2): 66.
[4]
Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018; 138: 271-81.
[http://dx.doi.org/10.1016/j.diabres.2018.02.023] [PMID: 29496507]
[5]
Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world--a growing challenge. N Engl J Med 2007; 356(3): 213-5.
[http://dx.doi.org/10.1056/NEJMp068177] [PMID: 17229948]
[6]
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27(5): 1047-53.
[http://dx.doi.org/10.2337/diacare.27.5.1047] [PMID: 15111519]
[7]
Khodabandehloo H, Gorgani-Firuzjaee S, Panahi G, Meshkani R. Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction. Transl Res 2016; 167(1): 228-56.
[http://dx.doi.org/10.1016/j.trsl.2015.08.011] [PMID: 26408801]
[8]
Cornelis MC, Zaitlen N, Hu FB, Kraft P, Price AL. Genetic and environmental components of family history in type 2 diabetes. Hum Genet 2015; 134(2): 259-67.
[http://dx.doi.org/10.1007/s00439-014-1519-0] [PMID: 25543539]
[9]
Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002; 13(2): 84-9.
[http://dx.doi.org/10.1016/S1043-2760(01)00524-0] [PMID: 11854024]
[10]
Tsao TS, Lodish HF, Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol 2002; 440(2-3): 213-21.
[http://dx.doi.org/10.1016/S0014-2999(02)01430-9] [PMID: 12007537]
[11]
Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes 2008; 32(7): 13.
[http://dx.doi.org/10.1038/ijo.2008.233]
[12]
Matthaei S, Stumvoll M, Kellerer M, Häring HU. Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev 2000; 21(6): 585-618.
[http://dx.doi.org/10.1210/er.21.6.585] [PMID: 11133066]
[13]
Saltiel AR. Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. J Clin Invest 2000; 106(2): 163-4.
[http://dx.doi.org/10.1172/JCI10533] [PMID: 10903328]
[14]
Pajukanta P, Nuotio I, Terwilliger JD, et al. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 1998; 18(4): 369-73.
[http://dx.doi.org/10.1038/ng0498-369] [PMID: 9537421]
[15]
Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta Mol Cell Biol Lipids 2012; 1821(1): 21-56.
[http://dx.doi.org/10.1016/j.bbalip.2011.09.014]
[16]
Sentinelli F, Minicocci I, Montali A, et al. Association of RXR-gamma gene variants with familial combined hyperlipidemia: genotype and haplotype analysis. J Lipids 2013; 2013(1)517943
[17]
Wang H, Chu W, Hemphill C, Hasstedt SJ, Elbein SC. Mutation screening and association of human retinoid X receptor γ variation with lipid levels in familial type 2 diabetes. Mol Genet Metab 2002; 76(1): 14-22.
[http://dx.doi.org/10.1016/S1096-7192(02)00016-1] [PMID: 12175776]
[18]
Hsieh CH, Pei D, Hung YJ, Hsiao FC. C-H H. Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy. Genet Mol Res 2011; 10(4): 3545-51.
[http://dx.doi.org/10.4238/2011.December.5.4] [PMID: 22180072]
[19]
Chen YL, Pei D, Hung YJ, et al. Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes. Genet Mol Res 2015; 14(1): 2518-26.
[http://dx.doi.org/10.4238/2015.March.30.10] [PMID: 25867398]
[20]
Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci 2014; 11(11): 1185-200.
[http://dx.doi.org/10.7150/ijms.10001] [PMID: 25249787]
[21]
Ohlson LO, Larsson B, Björntorp P, et al. Risk factors for type 2 (non-insulin-dependent) diabetes mellitus. Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913. Diabetologia 1988; 31(11): 798-805.
[http://dx.doi.org/10.1007/BF00277480] [PMID: 3234634]
[22]
Weijnen CF, Rich SS, Meigs JB, Krolewski AS, Warram JH. Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies. Diabet Med 2002; 19(1): 41-50.
[http://dx.doi.org/10.1046/j.1464-5491.2002.00624.x] [PMID: 11869302]
[23]
Shulman AI, Mangelsdorf DJ. Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med 2005; 353(6): 604-15.
[http://dx.doi.org/10.1056/NEJMra043590] [PMID: 16093469]
[24]
Davies PJ, Berry SA, Shipley GL, et al. Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity. Mol Pharmacol 2001; 59(2): 170-6.
[http://dx.doi.org/10.1124/mol.59.2.170] [PMID: 11160850]
[25]
Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol 2013; 28(3): 205-21.
[http://dx.doi.org/10.1007/s10654-013-9790-2] [PMID: 23456138]
[26]
Afzal S, Bojesen SE, Nordestgaard BG. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clin Chem 2013; 59(2): 381-91.
[http://dx.doi.org/10.1373/clinchem.2012.193003] [PMID: 23232064]

Rights & Permissions Print Cite
Article Metrics
23
2
© 2024 Bentham Science Publishers | Privacy Policy