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摘要
生活方式因素,例如酒精摄入量,已经给公共健康带来了沉重负担。由于多种因素,全球酒精消费量正在增加,其中包括该成瘾性物质的法律地位和社会接受性,而且容易获得。在美国,酒精是第三大可预防的主要死因(仅次于烟草,不良饮食和缺乏运动),估计每年有88,000人死于与酒精有关的原因,占在职成年人的十分之一。此外,过量饮酒的经济负担使美国损失了约2490亿美元(与狂饮有关的1911亿美元)。尽管男人可能比女人喝更多的酒,但妇女面临与酒精有关的问题的风险要高得多。饮酒也被认为是最常见的非传染性疾病之一,它影响生殖健康。这篇综述文章总结了有关子宫肌瘤(UFs)与酒精相关的发病机理的最新知识,并重点介绍了响应酒精摄入而促进UFs产生的分子机制。此外,本综述总结了酒精对UFs发病机制中涉及的各种因素(如类固醇激素,生长因子和细胞因子)水平的影响。还讨论了有害酒精作用的动物研究和未来方向。
关键词: 酒精,超滤,流行病学研究,类固醇激素,生长因子,细胞因子,生殖疾病,新陈代谢。
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