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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

Exenatide在阿尔茨海默病中作用的初步研究

卷 16, 期 8, 2019

页: [741 - 752] 页: 12

弟呕挨: 10.2174/1567205016666190913155950

价格: $65

摘要

背景：有力的临床前证据表明，Exenatide是一种用于治疗2型糖尿病的胰高血糖素样肽-1（GLP-1）受体激动剂，在阿尔茨海默氏病（AD）中具有神经保护作用和可缓解疾病。 目的：我们进行了一项为期18个月的双盲随机安慰剂对照II期临床试验，以评估Exenatide的安全性和耐受性，并探讨AD早期临床，认知和生物标志物结局的治疗反应。 方法：18名以脑脊液（CSF）生物标志物为基础的高概率AD参与者完成了整个研究，然后被赞助者提前终止。部分结果可用于21。 结果：Exenatide安全且耐受性好，在口服葡萄糖耐量试验中显示出与安慰剂相比，预期的恶心发生率更高，食欲下降，葡萄糖和GLP-1下降。与安慰剂相比，Exenatide治疗在临床和认知指标，MRI皮质厚度和体积，或脑脊液，血浆和血浆神经元细胞外囊泡（EV）中的生物标志物方面均无差异或趋势，只是降低了EV中的Aβ42。 结论：较低的EVAβ42的阳性发现支持新出现的证据，即血浆神经元EV为在AD临床试验中证明生物标志物应答提供了有效的平台。由于提前终止，该研究的动力不足，因此我们无法得出任何肯定的结论。然而，对次要结局的分析表明，没有证据支持Exenatide在临床AD中可以缓解疾病的假说，降低EVAβ42本身并不能改善AD的认知结局。

关键词: GLP-1激动剂，exenatide，记忆，糖尿病，安慰剂，阿尔茨海默病。

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