Phytoconstituents from Mother Nature against SARS-CoV-2/ COVID-19

Coronavirus disease-2019 (COVID-19) is a pandemic disease due to the infectious virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”. Scientifically validated phytoconstituents sourced from “Mother Nature” are now an area of interest and targeted approach as a worldwide prophylactic measure against SARS-CoV-2. This section focuses on providing a clear understanding of the structure of SARS-CoV-2 as well as verified phytoconstituents from traditional medicine (TM) for addressing the virus with all feasible targets. Target-specific inflammatory pathways triggered by SARS post-infection include NLRP3, Metallopeptidase Domain 17, JAK-STAT, p38-MAPK, endocytosis pathways e.g. Clathrin, HMGB1 as well as associated interleukins and cytokines are primarily highlighted, which directly or indirectly trigger the immune system and play a significant role. Selected Indian medicinal herbs and their possible leads are detailed below, with the goal of focusing on specific routes with a high likelihood of preventing pandemics in the future.

Keywords: COVID-19, Coronavirus, Mother Nature, Phytoconstituents, SARSCoV-2, Traditional Medicine.