Cytosolic Phospholipase A2 Inhibitors as Therapeutic Agents for Neural Cell Injury

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Cytosolic Phospholipase A2 Inhibitors as Therapeutic Agents for Neural Cell Injury



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 1(3): 193-204.

Author(s): A. A. Farooqui, Wei-YiOng, X.- R. Lu and L A Horrocks.

Affiliation: Department of Molecular and Cellular Biochemistry, 467 Hamilton Hall, The Ohio State University, 1645 Neil Ave., Columbus, OH 43210-1218, USA

Abstract

Cytosolic phospholipases A2 are a diverse group of enzymes with a growing number of members. These enzymes hydrolyze membrane glycerophospholipids into arachidonic acid and 1-acyl-lysophospholipids. Arachidonic acid and its metabolites (eicosanoids) play critical roles in the initiation and modulation of inflammation and oxidative stress. It is generally thought that the release of arachidonic acid by cytosolic phospholipase A2 is the rate-limiting step in the generation of eicosanoids. Neurological disorders, such as ischemia, spinal cord injury, and Alzheimers disease, are characterized by inflammatory reactions, oxidative stress, and increased cytosolic phospholipase A2 activity. Several cytosolic phospholipase A2 inhibitors were discovered recently. However, nothing is known about their neurochemical effects, mechanism of action, or toxicity in human or animal models of neurological disorders. Our recent studies have indicated that the use of cytosolic PLA2 inhibitors in kainic acid-induced toxicity model of neural injury can provide useful information on the beneficial effects of these compounds in brain tissue.

Keywords:

Cytosolic, Phospholipase, A2 Inhibitors, Neural Cell, eicosanoids, kainic acid, PLA2 inhibitors, neurochemical.



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Article Details

Volume: 1
Issue Number: 3
First Page: 193
Last Page: 204
Page Count: 12
DOI: 10.2174/1568014023355917
Price: $58
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