Regulation of Inflammation: A Review of Recent Advances in Anti- Inflammatory Strategies

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Regulation of Inflammation: A Review of Recent Advances in Anti- Inflammatory Strategies



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2(3): 274-283.

Author(s): P. S. Brenner and T Krakauer.

Affiliation: Department of Immunology and Molecular Biology 1425 Porter Street, USAMRIID Fort Detrick,Maryland 21702-5011, USA.

Abstract

Many chronic debilitating diseases result from uncontrolled inflammation. Inflammatory cells, such as neutrophils, eosinophils, basophils, mast cells, macrophages, endothelial cells, and platelets, respond to inflammatory stimuli and foreign substances by producing bioactive mediators, such as eicosanoids, chemokines, and cytokines. These mediators act as autocrines and paracrines by interacting with many cell types to amplify the inflammatory response. Studies of lipoxins, eicosanoids derived from the lipoxygenase pathways, provide evidence of endogenous antiinflammatory molecules to dampen the inflammatory response. This article reviews the recent advances in antiinflammatory research and provides insight into pharmaceutical and clinical relevance. Selective cyclooxygenase 2 inhibitors have currently been in the spotlight for their anti-inflammatory effects without the side effects of older, nonselective non-steroidal anti-inflammatory drugs. However, many new areas of interest in the regulation of the inflammatory response include leukotriene receptor antagonists, monoclonal antibodies to cytokines, and synthetic analogs of lipoxins.

Keywords:

eicosanoids, cyclooxygenase inhibitors, anti-inflammation.



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Article Details

Volume: 2
Issue Number: 3
First Page: 274
Last Page: 283
Page Count: 10
DOI: 10.2174/1568014033483752
Price: $58
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