Antioxidant Properties of Nitric Oxide in Cellular Physiological and Pathophysiological Mechanisms. The Implications of Biological Balance between NO and Oxidative Stress

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Antioxidant Properties of Nitric Oxide in Cellular Physiological and Pathophysiological Mechanisms. The Implications of Biological Balance between NO and Oxidative Stress



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 3(3): 181-188.

Author(s): Lisa A. Ridnour, Douglas D. Thomas, Daniele Mancardi, Sonia Donzelli, Nazerrano Paolocci, Pasquale Pagliaro, Katrina M. Miranda, Murali Krishna, John Fukuto, Matthew B. Grisham, James B. Mitchell, Michael G. Espey and David A Wink.

Affiliation: Radiation Biology Branch,National Cancer Institute / National Institutes of Health, Building 10, RoomB3-B69, Bethesda, MD 20892, USA

Abstract

The function of nitric oxide ( NO) in pathophysiology remains confounding as both protective and cytotoxic effects of NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of NO. However, the counteracting role of NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.

Keywords:

Antioxidant, pathophysiology, Nitric oxide.



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Article Details

Volume: 3
Issue Number: 3
First Page: 181
Last Page: 188
Page Count: 8
DOI: 10.2174/1568014043355311
Price: $58
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