Update on the Therapy of Behçets Disease

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Update on the Therapy of Behçets Disease



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(3): 339-348.

Author(s): T. Arayssi and A Hamdan.

Affiliation: American University of Beirut Medical Center, Internal Medicine Department, 3 Dag HammarskjoldPlaza, 8th floor, New York, NY 10017, USA.

Abstract

Behçets disease is a chronic inflammatory systemic disorder, characterized by a relapsing and remitting course. The main histopathological finding is a widespread vasculitis of the arteries and veins of any size. The prevalence of BD is highest in the Middle East, Mediterranean region and Asia. The usual age of onset is around 30, and the male to female ratio varies with the ethnic background. The cause of BD remains unknown. It is presumed to be multifactorial involving infectious triggers, genetic predisposition, and dysregulation of the immune system. The main objectives of therapy of BD are to relieve its symptoms, decrease recurrences and prevent irreversible damage. This choice, however, is limited by the paucity of high quality therapy trials. Therapy studies for this disease in general, lack high methodological quality and common outcome measures, making treatment of this disease for the most part empirical. Most randomized studies have focused on the treatment of ocular, mucocutaneous and musculoskeletal diseases, while data on the treatment of the other manifestations is based on uncontrolled data.

Keywords:

behcets disease, therapy, randomized clinical trials, diagnosis, pathogenesis, clinical manifestations.



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Article Details

Volume: 4
Issue Number: 3
First Page: 339
Last Page: 348
Page Count: 10
DOI: 10.2174/1568014054065230
Price: $58
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