Aggrecanase: The Family and Its Inhibitors

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Aggrecanase: The Family and Its Inhibitors



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(3): 251-264.

Author(s): R.- Q. Liu and J M Trzaskos.

Affiliation: Inflammation and Immunology Biology, Pharmaceutical Research Institute, Bristol Myers Squibb Co.,Princeton, NJ 08540, USA.

Abstract

Osteoarthritic joint disease is characterized by the progressive loss of articular cartilage resulting in functional impairment, pain and discomfort. The major components in cartilage, collagen and aggrecan, are lost during disease through the action of degradative proteolytic enzymes. The proteases responsible for aggrecan degradation are termed aggrecanases. The aggrecanases represent a family of enzymes with great therapeutic potential as targets for the treatment of osteoarthritis. Here we review the family of aggrecanases and the progress made toward the identification of potent and selective enzyme inhibitors for use as therapeutic agents.

Keywords:

aggrecanase, adamts, cartilage, osteoarthritis, mmp, aggrecan, protease, adam.



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Article Details

Volume: 4
Issue Number: 3
First Page: 251
Last Page: 264
Page Count: 14
DOI: 10.2174/1568014054065186
Price: $58
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