Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Anti-Inflammatory Activity of Tetracyclines: Applications to Human Disease



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(2): 132-152.

Author(s): P. J. Higgins, M. Draper and M Nelson.

Affiliation: Paratek Pharmaceuticals, 75 Kneeland Street, Boston, MA 02111.

Abstract

Tetracyclines possess anti-inflammatory characteristics which are largely independent of their antibacterial activity. A variety of in vitro biologic effects have been reported for tetracyclines in both immune and non-immune cells. The in vivo therapeutic efficacy of tetracyclines in diseases such as rheumatoid arthritis, multiple sclerosis, and stroke has also been demonstrated in both animal models and clinical studies. This review describes the experimental evidence which demonstrates the various non-antibacterial anti-inflammatory activities of tetracyclines and discusses possible mechanisms of action of these drugs.

Keywords:

Tetracycline, inflammation, autoimmunity, therapy, gastrointestinal symptoms, photosensitivity, tissue discoloration, allergic reaction, antibiotics, metalloproteases.



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Article Details

Volume: 10
Issue Number: 2
First Page: 132
Last Page: 152
Page Count: 21
DOI: 10.2174/1871523011109020132
Price: $58
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