The Pharmacokinetics of Biologic Agents

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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The Pharmacokinetics of Biologic Agents



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 9(1): 3-7.

Author(s): Turhan Dost.

Affiliation: Adnan Menderes University, Medical Faculty, Department of Pharmacology, Aydin, 09100 Turkey.

Abstract

The deficiency of conventional drugs that are used in inflammatory rheumatic diseases are not able to prevent from progression of diseases have resulted in the development of new drugs, such as TUMOR Necrosis Factor-α (TNF-α) blocking agents, Interleukin-1 (IL-1) receptor antagonist and Anti-B cell (CD20) antibody. Biologic agents are a clear advancement in drug therapy. These newer agents have mechanisms of action targeted toward specific components of the immune system, which enable them to provide more reliable outcomes with fewer limiting side effects. They are administered subcutaneously and/or intravenously. The goal of the biologic treatment is to slow or block specific components of the immune system and halt tissue destruction.

Keywords:

Biologic agents, pharmacokinetic, TNF-α blocking agents, IL-1 receptor antagonist, anti-B cell antibody, T-cell activator, IL-6 inhibitor.



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Article Details

Volume: 9
Issue Number: 1
First Page: 3
Last Page: 7
Page Count: 5
DOI: 10.2174/187152310790711700
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