Preparation and Characterization of Solid Dispersions of Rofecoxib

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

Download PDF Flyer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Claudiu T. Supuran
Neurofarba Department
University of Florence

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Preparation and Characterization of Solid Dispersions of Rofecoxib

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(6): 393-398.

Author(s): M. V. Ramana, Kamal Dua, M. Himaja and Kavita Pabreja.

Affiliation: Department of Pharmaceutical Technology, Faculty of Medicine & Health, International Medical University, No. 126, Jalan 19/155b, Bukit Jalil, 57000 KL, Malaysia.


The present study is aimed at improving the dissolution of poorly soluble drug, rofecoxib, using solid dispersion technique. The solid dispersions were prepared in different proportions using hydrophilic carriers like mannitol, and urea. The dissolution rate studies were performed in both simulated gastric fluid and simulated intestinal fluid. It is observed that the dissolution was affected by the acidity of the medium. Solid dispersions gave faster dissolution rate when compared to corresponding physical mixture and pure drug. In vivo absorption and anti-inflammatory activity studies of solid dispersions also confirmed the above results. The DSC thermogram and IR spectra revealed that there is no interaction of Rofecoxib with additives and the drug, rofecoxib is stable in solid dispersions.


Rofecoxib, solid dispersions, urea, mannitol, gastric fluid, physical mixture, anti-inflammatory, solid dispersions, Differential scanning calorimetric, Infrared.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 10
Issue Number: 6
First Page: 393
Last Page: 398
Page Count: 6
DOI: 10.2174/1871523011109060393
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science