Interaction between Phenols and Bovine Serum Albumin

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Interaction between Phenols and Bovine Serum Albumin



Anti-Infective Agents, 8(3): 268-271.

Author(s): Yuanzhi Song, Jimin Xie, Yunlong Wu, Min Chen, Ganqing Zhao, Xiaomeng Lv, Huoming Shu and Songtao Chen.

Affiliation: School of Chemistry&Chemical Engineering, Jiangsu University, Zhenjiang 212013, People's Republic of China.

Abstract

The interactions between bovine serum albumin and phenols have been studied by cyclic voltammetry (CV). The interaction divides into specific and non-specific binding sites, and mainly ascribes to the electronic force. One specific binding site between bovine serum albumin and p-aminophenol (p-AP) as well as p-quinonimine (p-AQ) is obtained. Both the specific binding number of p-AP and p-AQ binding bovine serum albumin were in the ratio of 5:1. Two specific binding sites for p-hydroquinone (p-HQ) and p-benzoquinone (p-BQ) were found, respectively. The specific binding number of p-HQ are 15:1 and 9:1, respectively, while total specific binding number was 26:1. Moreover, the specific binding number of p-BQ was 15:1 and 9:1, respectively, with total specific binding number was 26:1. Three specific binding sites for pyrocatechol (PC) were obtained, and two specific binding sites for o-benzoquinone (o-BQ) were observed. The specific binding number of PC are 11:1, 3:1 and 8:1, respectively, total specific binding number being 22:1. However, the specific binding number of o-BQ was 3:1 and 5:1 respectively, with total specific binding number being 8:1.

Keywords:

Phenols, bovine serum albumin, interaction, electrochemistry.



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Article Details

Volume: 8
Issue Number: 3
First Page: 268
Last Page: 271
Page Count: 4
DOI: 10.2174/187152109788680234
Price: $58
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