Boronated Compounds for Imaging Guided BNCT Applications

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Boronated Compounds for Imaging Guided BNCT Applications

Anti-Cancer Agents in Medicinal Chemistry, 12(5): 543-553.

Author(s): Simonetta Geninatti-Crich, Annamaria Deagostino, Antonio Toppino, Diego Alberti, Paolo Venturello and Silvio Aime.

Affiliation: Dipartimento di Chimica Generale e Chimica Organica, Universita degli studi di Torino, Via Pietro Giuria, 7, 10125 Torino, Italy.


Boron neutron capture therapy (BNCT) is based on the capture of thermal neutrons by boron 10 (10B) nuclei that have been selectively delivered to tumor cells. The amount of 10-30 μg of boron for g of tumor mass is needed to attain an acceptable therapeutic advantage. Despite that the potentialities of BNCT have been demonstrated in several preclinical studies, this technique has not yet been fully accepted in the armory of tools for tumor treatment. This is partly due to the differences in the uptake and distribution of 10B among patients and also to the uncertainty found in the determination of tumor-to-blood 10B concentration ratio. Attention is now being payed to use the main imaging techniques to determine the in vivo biodistribution of BNCT agents. Most of the work has been devoted to the most promising BNCT agents, namely BPA, BSH and carborane derivatives. This review surveys studies carried out over the last decade, and outlines the role that NMR, PET and SPECT imaging may have to improve the efficacy of BNCT.


Biodistribution, BNCT, 10B NMR, Imaging, 11B NMR, BPA, BSH, Carboranes, 19F NMR, 1H-MRI, 1H-MRS, PET, SPECT, Therapy, Tumors .

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 12
Issue Number: 5
First Page: 543
Last Page: 553
Page Count: 11
DOI: 10.2174/187152012800617786
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science