Aminophosphonic Acids of Potential Medical Importance

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Aminophosphonic Acids of Potential Medical Importance

Anti-Cancer Agents in Medicinal Chemistry, 1(3): 301-312.

Author(s): Pawel Kafarski and Barbara Lejczak.

Affiliation: Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.


Aminophosphonic acids were almost unknown in 1959 but today they are the subject of more than 6000 papers. Their negligible mammalian toxicity, and the fact that they very efficiently mimic aminocarboxylic acids makes them extremely important antimetabolites, which compete with their carboxylic counterparts for the active sites of enzymes and other cell receptors. Although biological importance of these compounds was recognized over 50 years ago they still represent promising and somewhat undiscovered class of potential drugs.

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Article Details

Volume: 1
Issue Number: 3
First Page: 301
Last Page: 312
Page Count: 12
DOI: 10.2174/1568011013354543
Price: $58

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