A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

Anti-Cancer Agents in Medicinal Chemistry, 4(5): 393-394.

Author(s): Giovanni Capranico.

Affiliation: Department of Biochemistry “G Moruzzi”, Alma Mater Studiorum University of Bologna, via Irnerio 48,40126 Bologna, Italy.


The cancer mortality remains high, although progress has been attained by chemotherapy and other therapeutic strategies. Effective cancer prevention interventions would markedly reduce the cancer mortality burden, thus chemoprevention and chemotherapy must be seen as complementary approaches to fight human cancers. Nevertheless, our understanding of drug mechanisms of action is rather limited as we do not know the behaviour of highly-complex regulatory networks of the cell and how they respond to a particular small molecule. Similarly, that limits a truly rational approach to drug discovery and identification of good molecular targets. Until we get deeper insights into fundamental mechanisms of cellular functions, the approach to drug design and discovery will remain empirical.


regulation mechanisms, drug discovery, antitumor activity, molecular target, chemoprevention, dna topoisomerase, rational approach.

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Article Details

Volume: 4
Issue Number: 5
First Page: 393
Last Page: 394
Page Count: 2
DOI: 10.2174/1568011043352821
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

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