A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

A Rational Selection of Drug Targets Needs Deeper Insights into General Regulation Mechanisms



Anti-Cancer Agents in Medicinal Chemistry, 4(5): 393-394.

Author(s): Giovanni Capranico.

Affiliation: Department of Biochemistry “G Moruzzi”, Alma Mater Studiorum University of Bologna, via Irnerio 48,40126 Bologna, Italy.

Abstract

The cancer mortality remains high, although progress has been attained by chemotherapy and other therapeutic strategies. Effective cancer prevention interventions would markedly reduce the cancer mortality burden, thus chemoprevention and chemotherapy must be seen as complementary approaches to fight human cancers. Nevertheless, our understanding of drug mechanisms of action is rather limited as we do not know the behaviour of highly-complex regulatory networks of the cell and how they respond to a particular small molecule. Similarly, that limits a truly rational approach to drug discovery and identification of good molecular targets. Until we get deeper insights into fundamental mechanisms of cellular functions, the approach to drug design and discovery will remain empirical.

Keywords:

regulation mechanisms, drug discovery, antitumor activity, molecular target, chemoprevention, dna topoisomerase, rational approach.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 4
Issue Number: 5
First Page: 393
Last Page: 394
Page Count: 2
DOI: 10.2174/1568011043352821
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science