Gold Nanostructures as Photothermal Therapy Agent for Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Gold Nanostructures as Photothermal Therapy Agent for Cancer

Anti-Cancer Agents in Medicinal Chemistry, 11(10): 953-964.

Author(s): Jihye Choi, Jaemoon Yang, Eunji Jang, Jin-Suck Suh, Yong-Min Huh, Kwangyeol Lee and Seungjoo Haam.

Affiliation: Department of chemistry, Korea University Seoul 136-701, Republic of Korea.


Well-designed photothermal nanostructures have attracted many scientists pursuing a better means to accurately diagnose cancer and assess the efficacy of treatment. Recently, gold-based nanostructures (nanoshells, nanorods and nanocages) have enabled photothermal ablation of cancer cells with near-infrared (NIR) light without damaging normal human tissues and in particular, animal studies and early clinical testing showed the great promise for these materials. In this review article, we first discuss the mechanism of the cellular death signaling by thermal stress and introduce the intrinsic properties of gold nanostructures as photothermal agent for cancer treatment. Then the overview follows for evolving researches for the synthesis of various types of gold nanostructures and for their biomedical applications. Finally we introduce the optimized therapeutic strategies involving nanoparticle surface modification and laser operation method for an enhanced accumulation of gold nanostructures to the target cancer as well as for an effective cancer cell ablation.


Gold nanostructures, photothermal therapy, Near-IR, cancer, chemotherapy, apoptosis, procaspase, anti-HER2-conjugated gold nanoshells.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 10
First Page: 953
Last Page: 964
Page Count: 12
DOI: 10.2174/187152011797927599
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science