Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)



Anti-Cancer Agents in Medicinal Chemistry, 8(3): 241-268.

Author(s): Xiang Zheng and Ravindra K Pandey.

Affiliation: Photodynamic Therapy Center,Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263,USA.

Abstract

In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.

Keywords:

Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates.



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Article Details

Volume: 8
Issue Number: 3
First Page: 241
Last Page: 268
Page Count: 28
DOI: 10.2174/187152008783961897
Price: $58
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