Shedding Light on Serum Vitamin D Concentrations and the Risk of Rarer Cancers

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Shedding Light on Serum Vitamin D Concentrations and the Risk of Rarer Cancers

Anti-Cancer Agents in Medicinal Chemistry, 13(1): 65-69.

Author(s): Kathy J. Helzlsouer and Lisa Gallicchio.

Affiliation: The Prevention and Research Center, 227 St. Paul Place, Baltimore, Maryland 21202.


Cancer is a broad term for many disparate diseases with different etiologies, commonly classified by affected organ site. This review summarizes the published evidence from prospective cohort studies examining the associations between vitamin D, measured as serum 25-hydroxyvitamin D (25OHD) concentrations, and the risk of rarer cancer sites including pancreatic, non-Hodgkin lymphoma, ovarian, endometrial, kidney, gastric and esophageal cancer. Overall, evidence from prospective cohort studies provides little support for a protective association between adequate or higher serum 25OHD concentrations and risk of these rarer cancer sites. Additionally, controversy persists concerning a potential increased risk of pancreatic cancer associated with serum 25OHD levels >100 nmol/L due to conflicting results reported by two large prospective pooling projects.


25-hydroxyvitamin D, Bladder cancer, Cancer, Cohort, Endometrial cancer, Esophageal cancer, Gastric cancer, Kidney cancer, Nested case-control study, Non-Hodgkin lymphoma, Ovarian cancer, Pancreatic cancer, Prospective studies, Vitamin D.

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Article Details

Volume: 13
Issue Number: 1
First Page: 65
Last Page: 69
Page Count: 5
DOI: 10.2174/1871520611307010065

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