Introduction: MMPs, ADAMs/ADAMTSs Research Products to Achieve Big Dream

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Introduction: MMPs, ADAMs/ADAMTSs Research Products to Achieve Big Dream

Anti-Cancer Agents in Medicinal Chemistry, 12(7): 688-706.

Author(s): Isao Okazaki and Kazuki Nabeshima.

Affiliation: Department of Internal Medicine, Sanno Hospital, International University of Health and Welfare, 8-10-16 Akasaka, Minato-ku, Tokyo 107-0052, Japan.


Matrix metalloproteinases (MMPs) are known to participate in cancer invasion and metastasis. Copious research on MMPs and their inhibitors has promoted the understanding of the mechanisms of cancer invasion and metastasis as well as the development of effective drugs for cancer treatment. This review discusses the classification of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in relation to tumor growth and invasion mechanisms via signal transduction, followed by the possibilities for cancer treatment. The review focuses especially on the development of anti-cancer agents in the field of MMP science.


Matrix metalloproteinase (MMP), A disintegrin and metalloproteinase (ADAM), A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS), Tissue inhibitor of metalloproteinases (TIMP), Cancer invasion, Cancer metastasis, Cancer treatment, Anti-cancer agents, cancer cellinvasion, Peptidases.

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Article Details

Volume: 12
Issue Number: 7
First Page: 688
Last Page: 706
Page Count: 19
DOI: 10.2174/187152012802650200
Price: $58

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