<![CDATA[Syringomyelia]]> https://benthamscience.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Thu, 28 Mar 2024 18:16:50 +0000 <![CDATA[Syringomyelia]]> https://benthamscience.com https://benthamscience.com <![CDATA[Quality of Life in Individuals Affected by Arnold Chiari Malformation: Comparison and Validation of a Measurement Instrument]]>https://benthamscience.comarticle/87084

Methods: The English CSP instrument has a good internal validity and consistency. We used a standardized procedure for the linguistic validation of the translated scale. For the psychometric validation, we recruited 215 individuals with ACM and calculated the Cronbach&339;s alpha for the sample. The construct was validated by analyzing the age, sex, and presence of syringomyelia, as well as by correlating the results with the sickness impact profile 30 (SIP-30) questionnaire, which can also evaluate quality of life in this type of patient.

Results: The Spanish version of the CSP has good internal consistency and validity (Cronbach’s alpha of 0.90); age, sex, and the presence of syringomyelia does not significantly affect the quality of life of patients with ACM. There was a direct and significant correlation between the Spanish CSP and the validated SIP-30 questionnaire results (p < 0.05). Further analysis showed a positive correlation for the physical and psychological scopes of the CSP and SIP-30 questionnaires, but not for their functional and social scopes.

Conclusion: This version of the CSP is a valid and reliable instrument for measuring quality of life in patients with ACM in the Spanish context.]]> <![CDATA[Mevalonate Cascade and Small Rho GTPase in Spinal Cord Injury]]>https://benthamscience.comarticle/73026

Limited regeneration capacity of nerve fibers in adult CNS has been considered the main obstacle for finding a SCI cure. Over the past two decades, the identity of inhibitory factors for regeneration has been widely investigated. It is well-established that the Rho/ROCK kinase system is specifically activated by the components of damaged spinal cord tissue, including oligodendrocytes and myelin, as well as extracellular matrix. This has led many groups to hypothesize that statin therapy may in fact enhance the current neurorestorative approaches. In this mini-review, a summary of SCI pathophysiology is discussed and the current literature targeting the regeneration obstacles in SCI are reviewed, with special attention to recent publications of the past decade. In addition, we focus on the current literature involving the use of pharmacological and molecular inhibitors of small GTPase molecules for treatment of neurotrauma. Inhibiting these molecules has been shown to increase neuroprotection, enhance axonal regeneration, and facilitate the implementation of cell replacement therapies. Based upon available literature, the need for clinical trials involving targeted inhibition of GTPase molecules remains strong. Some of these drugs are widely used for other diseases, and therefore re-purposing their application for neurotrauma can be fasttracked. These approaches can potentially modify the inhibitory environment of nervous tissue to allow the spontaneous repair capacity of injured tissue.

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<![CDATA[Merging Transport Data for Choroid Plexus with Blood-Brain Barrier to Model CNS Homeostasis and Disease More Effectively]]>https://benthamscience.comarticle/78358 <![CDATA[Advanced Techniques for Imaging the Human Spinal Cord: Review of Literature]]>https://benthamscience.comarticle/67250 <![CDATA[HDL Genetic Defects]]>https://benthamscience.comarticle/61077

The HDL-C concentration in the blood may not be as important as the function of this lipid fraction. The genetic defects affecting plasma HDL-C concentrations do not always show a consistent relationship with atherosclerosis.

Familial hypoalphalipoproteinaemia is associated with mutations in genes responsible for the transport proteins or the enzymes involved in the biogenesis of HDL-C. Inheritance of a Milano mutation of apolipoprotein A1 decreases the risk of atherosclerotic disease despite low circulating levels of HDL-C.

Tangier disease and Fish Eye disease are caused by mutations in the ATP binding cassette A1 (ABCA1), a transport protein, and lecithin cholesterol acyl transferase (LCAT), an enzyme, involved in the esterification of cholesterol, respectively. Patients with these conditions have very low levels of HDL-C concentration. The association between both these conditions and the risk of cardiovascular disease (CVD) is variable and inconsistent.

Understanding the molecular mechanism of HDL biogenesis not only helped in defining the pathophysiology of low and high HDL-C syndromes, but also in developing new treatment options to raise HDL-C levels.]]> <![CDATA[Restless Legs Syndrome in Multiple Sclerosis]]>https://benthamscience.comarticle/48558

The purpose of the present review is (i) to summarize the epidemiological data and clinical characteristics of RLS in MS patients in order to increase sensitivity to this disorder; (ii) to document the substantial body of evidence in support of a symptomatic origin of RLS in MS and from this (iii) to delineate the proposition that MS may represent a clinical model to study RLS-associated pathological changes.

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<![CDATA[ Long Term Recovery of Diaphragmatic Function in a Patient with Unilateral Diaphragmatic Pacemaker]]>https://benthamscience.comarticle/28909 <![CDATA[ Adult Stem Cell Transplants for Spinal Cord Injury Repair: Current State in Preclinical Research]]>https://benthamscience.comarticle/33564 <![CDATA[ Current Status and Prospective Application of Stem Cell-Based Therapies for Spinal Cord Injury]]>https://benthamscience.comarticle/32895 <![CDATA[ L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies]]>https://benthamscience.comarticle/1479 <![CDATA[ Neuropathic Pain: Some Clues for Future Drug Treatments]]>https://benthamscience.comarticle/25974 <![CDATA[ Stem Cell Therapy for Spinal Cord Injury]]>https://benthamscience.comarticle/17886 <![CDATA[ Monitoring Cell Therapy Using Iron Oxide MR Contrast Agents]]>https://benthamscience.comarticle/7280 <![CDATA[ Endogenous and Exogenous CNS Derived Stem / Progenitor Cell Approaches for Neurotrauma]]>https://benthamscience.comarticle/6677 <![CDATA[ Research on the Possibility of Overcoming Traumatic Paraplegia and Its First Clinical Results]]>https://benthamscience.comarticle/5508 <![CDATA[ Eph/ephrin Signaling as a Potential Therapeutic Target After Central Nervous System Injury]]>https://benthamscience.comarticle/4688 <![CDATA[ Phosphodiesterase 5 Inhibitors in the Treatment of Erectile Dysfunction]]>https://benthamscience.comarticle/2800 <![CDATA[ Back Pain in Children and Adolescents: Etiology, Clinical Approach and Treatment]]>https://benthamscience.comarticle/2432