<![CDATA[Pituitary Cancer]]> https://benthamscience.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Sat, 02 Mar 2024 00:37:41 +0000 <![CDATA[Pituitary Cancer]]> https://benthamscience.com https://benthamscience.com <![CDATA[IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats]]>https://benthamscience.comarticle/92854

Objective: Our aim was to implement long-term IGF-I gene therapy in pituitary prolactinomas in senile female rats.

Methods: Here, we assessed the long-term effect of IGF1 gene therapy in the hypothalamus of young (4 mo.) and aging (24 mo.) female rats carrying spontaneous pituitary prolactinomas. We constructed and injected a Helper-Dependent (HD) adenovector expressing the gene for rat IGF1 or the reporter red fluorescent protein DsRed. Ninety-one days post vector injection, all rats were sacrificed and their brains and pituitaries fixed. Serum prolactin (PRL), Estrogen (E2) and progesterone (P4), as well as hypothalamic IGF1 content, were measured by RIA. Anterior pituitaries were immunostained with an anti-rat PRL antibody and submitted to morphometric analysis.

Results: DsRed expression in the Mediobasal Hypothalamus (MBH) was strong after the treatment in the DsRed group while IGF1 content in the MBH was higher in the IGF1 group. The IGF1 treatment affected neither pituitary weight nor PRL, E2 or P4 serum levels in the young rats. In the old rats, IGF1 gene therapy reduced gland weight as compared with intact counterparts and tended to reduce PRL levels as compared with intact counterparts. The treatment significantly rescued the phenotype of the lactotropic cell population in the senile adenomas.

Conclusion: We conclude that long-term hypothalamic IGF1 gene therapy is effective to rescue spontaneous prolactinomas in aging female rats.]]> <![CDATA[Molecular Mechanisms Underlying Psychological Stress and Cancer]]>https://benthamscience.comarticle/73997 <![CDATA[Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy]]>https://benthamscience.comarticle/61376 <![CDATA[Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy]]>https://benthamscience.comarticle/62008 <![CDATA[Tumor-Targeting Peptides and Small Molecules as Anti-Cancer Agents to Overcome Drug Resistance]]>https://benthamscience.comarticle/55418 <![CDATA[New and Highly Potent Antitumor Natural Products from Marine-Derived Fungi: Covering the Period from 2003 to 2012]]>https://benthamscience.comarticle/56503 <![CDATA[Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology]]>https://benthamscience.comarticle/45578 <![CDATA[ Inhibiting the Enzymes of the Endothelin and Renin-Angiotensin Systems in Cancer]]>https://benthamscience.comarticle/3051 <![CDATA[ Neuropeptides as Autocrine Growth Factors in Cancer Cells]]>https://benthamscience.comarticle/8280