Aims & Scope
The
scope includes in vitro systems, including CYP-450; enzyme induction and
inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics,
toxicokinetics, species scaling and extrapolations; P-glycoprotein and
transport carriers; target organ toxicity and interindividual variability; drug
metabolism and disposition studies; extrahepatic metabolism; phase I and phase
II metabolism; bioactivation; recent developments for the identification of
drug metabolites, reactive intermediate, and glutathione conjugates.
Additionally, LC/MS and other key detection methods,
including ligand binding assays, sample preparation, chromatography and
separation sciences, and
method development and validation, are included, with applications in drug and metabolite assays,
pharmacokinetic/toxicokinetic assays, biomarker assays, immunogenicity assays,
diagnostic assays.
