Standardization of 123I-meta-iodobenzylguanidine Heart-To-Mediastinum Ratio: Technical Aspects

Standardization of ¹²³I-meta-iodobenzylguanidine Heart-To-Mediastinum Ratio: Technical Aspects

Author(s): Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura and Yumiko Kirihara

Pp: 222-226 (5)

* (Excluding Mailing and Handling)

Abstract

The heart-to-mediastinum ratio (HMR) in planar images has been used for the evaluation of cardiac ¹²³I-meta-iodobenzylguanidine (MIBG) uptake. However, the HMR values are influenced by both collimators and the cardiac and mediastinal regions of interests (ROI). Two technical developments in semi-automated ROI setting software and a calibration method for HMR values were described in this article.

Keywords: ¹²³I-MIBG, Heart-to-mediastinum ratio, Multicenter study, Planar imaging, Quantification, Region of interest, smartMIBG, smartMIBG-HF, Standardization, Washout rate.