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Reviews on Recent Clinical Trials

Volume 16, 4 Issues, 2021
ISSN: 1876-1038 (Online)
ISSN: 1574-8871 (Print)
This journal supports open access

Aims & Scope

Reviews on Recent Clinical Trials publishes high quality full-length/mini reviews, original research articles, interesting case reports, drug clinical trial studies and guest edited thematic issues on recent clinical trials of major importance. The journal's aim is to publish the highest quality articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development, therapeutics, meta analysis, trial logistics, design and conduct of trials, statistical methods, synthesis and evidence evaluation, decision analysis, reviews, case reports and commentaries on current or controversial issues.

The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.

Reviews on Recent Clinical Trials

,

Volume 16

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Number 3





Letter to the Editor   Open Access

Impact of Covid-19 on Mental Health: An Overview

, 16(3): 227 - 231

Minal M. Kshirsagar*, Arun S. Dodamani, Girija A. Dodamani, Vrushali R. Khobragade and Rahul N. Deokar


DOI: 10.2174/1574887115666210105122324


Review Article

Phase 1 Clinical Trials of Small Molecules: Evolution and State of the Art

, 16(3): 232 - 241

John J. Sramek, Michael F. Murphy, Sherilyn Adcock, Jeffrey G. Stark and Neal R. Cutler*


DOI: 10.2174/1574887116666210204125844


Review Article

Review and Analysis of Massively Registered Clinical Trials of COVID-19 using the Text Mining Approach

, 16(3): 242 - 257

Swayamprakash Patel*, Ashish Patel, Mruduka Patel, Umang Shah, Mehul Patel, Nilay Solanki and Suchita Patel


DOI: 10.2174/1574887115666201202110919


Review Article



Review Article

Infection, Infectious Agents and Vascular Disease

, 16(3): 262 - 271

Nicola Ielapi, Francesco Caprino, Biagio Malizia, Antonio Sisinni, Lwanga Ssempijja, Michele Andreucci, Noemi Licastro and Raffaele Serra*


DOI: 10.2174/1574887116666210325124045


Research Article

Pathogenetic Correction of the Enteric Insufficiency Syndrome in Patients with Advanced Peritonitis

, 16(3): 272 - 278

Fedor N. Ilchenko, Sergey G. Grivenko, Igor V. Kaminsky, Yuriy V. Artemov, Evelina R. Kondratiuk, Vitalii B. Kaliberdenko, Shanmugaraj Kulanthaivel* and Keerthanaa Balasundaram


DOI: 10.2174/1574887115666201228151727


Research Article

The Clinical Difference between Gabapentin and Pregabalin: Data from a Pilot Comparative Trial

, 16(3): 279 - 287

Omar Gammoh*, Ahmed Al-Smadi, Mohammad Q. Shawagfeh, Thani Abadi, Jawad Kasawneh, Sukaina Malkawi and Sima Zein


DOI: 10.2174/1574887116666210201110507


Articles Ahead of Print

Moderate Hypofractionated Radiotherapy for Localized Prostate Cancer: The Triumph of Radiobiology


Andromachi Kougioumtzopoulou*, Kalliopi Platoni, Anna Zygogianni, George Kounadis, Konstantinos N. Syrigos, Adamantia Psyrri, Aristotelis Bamias, Nikolaos Kelekis and Vasileios Kouloulias


DOI: 10.2174/1574887116666210509004418
View Abstract View on PubMed


Abstracts Ahead of Print

Deep Neck Infections: decisional algorithm for patients with multiple spaces involvement


Filippo Ricciardiello, Salvatore Mazzone, Pasquale Viola*, Gianluca Guggino, Giuseppe Longo, Alberto Napolitano, Giuseppe Russo, Giulio Sequino, Flavia Oliva, Pasquale Salomone, Marco Perrella, Giovanni Marco Romano, Pietro Cinaglia, Teresa Abate, Maurizio Gargiulo, Davide Pisani and Giuseppe Chiarella


DOI: 10.2174/1574887116666210910153033
View Abstract



Practical Review of Mechanical Ventilation in Adults and Children in The Operating Room and Emergency Department


Christian Zanza*, Yaroslava Longhitano, Mirco Leo, Tatsiana Romenskaya, Francesco Franceschi, Andrea Piccioni, Ingrid Marcela Pabon, Maria Teresa Santarelli and Fabrizio Racca


DOI: 10.2174/1574887116666210812165615
View Abstract




Current Strategies to Minimize Ischemia-Reperfusion Injury in Liver Transplantation: A Systematic Review.


Carlo Gazia, Ilaria Lenci, Tommaso M Manzia, Milana Martina, Giuseppe Tisone, Roberta Angelico, Ludovico Abenavoli, Giuseppe Grassi, Alessandro Signorello and Leonardo Baiocchi*


DOI: 10.2174/1574887116666210729112932
View Abstract


Clinical Trials and Machine Learning: Regulatory Approach Review


Diego Alejandro Dri*, Maurizio Massella, Donatella Gramaglia, Carlotta Marianecci and Sandra Petraglia


DOI: 10.2174/1574887116666210715114203
View Abstract



Solving the gap between HCV detection and treatment in prison. HCV-RNA testing and treatment in a cohort of new arriving convicts in Southern Italy


Carmine Izzo*, Mario Masarone, Pietro Torre , Giuseppe Melara , Giuseppe De Matteis , Antonio De Luna, Antonio Maria Pagano and Marcello Persico *


DOI: 10.2174/1574887116666210612033824
View Abstract



Published Contents

Editor's Choice

Intravenous Magnesium – Lidocaine - Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy

, 2021; 16(3): 288 - 293

Christian Zanza*, Yaroslava Longhitano, Edwin Lin, Jerry Luo, Marco Artico, Benedetta Savarese, Valeria Bonato, Andrea Piccioni, Francesco Franceschi, Samanta Taurone, Ludovico Abenavoli and Jack Marshall Berger


DOI: 10.2174/1574887115666201202105620



New Strategies for Clinical Trials in Autism Spectrum Disorder

, 2021; 16(2): 131 - 137

Rini Pauly, Catherine A. Ziats, Ludovico Abenavoli, Charles E. Schwartz and Luigi Boccuto*


DOI: 10.2174/1574887115666201120093634



The Management of Hemorrhoidal Disease by Dearterialization and Mucopexy

, 2021; 16(1): 60 - 66

Veronica De Simone, Francesco Litta*, Angelo Parello, Paola Campennì, Raffaele Orefice, Angelo Alessandro Marra, Marta Goglia and Carlo Ratto


DOI: 10.2174/1574887115666200506091306




Indications for Non-Invasive Ventilation in Respiratory Failure

, 2020; 15(4): 251 - 257

Simone Maria Navarra, Maria Teresa Congedo and Mariano Alberto Pennisi*


DOI: 10.2174/1574887115666200603151838




Serum Levels of Granulocyte-Macrophage-colony-stimulating Factor and Stem-cell Factor During Liver Regeneration after Partial Hepatectomy in Humans

, 2020; 15(2): 131 - 136

Diego Fiume , Ilaria Lenci, Martina Milana, Tommaso M. Manzia, Renato Massoud, Laura Tariciotti, Carmelo Russo, Luca Toti and Leonardo Baiocchi*


DOI: 10.2174/1574887115666200123113623



An Industry Perspective on Risks and Mitigation Strategies Associated with Post Conduct Phase of Clinical Trial

, 2020; 15(1): 28 - 33

Seema Bhagat*, Vaibhavi K. Kapatkar, Ashish Mane, Colette Pinto, Devang Parikh, Gaurav Mittal and Rishi Jain


DOI: 10.2174/1574887114666191016103332



Domino Liver Transplantation: Where are we Now?

, 2019; 14(3): 183 - 188

Francesco Santopaolo, Ilaria Lenci, Alessandra Bosa, Mario Angelico, Martina Milana and Leonardo Baiocchi*


DOI: 10.2174/1574887114666190320123824




Open Access Articles


Review on Recent Trials Evaluating the Effect of Intravitreal Injections of Anti-VEGF Agents on the Macular Perfusion of Diabetic Patients with Diabetic Macular Edema

, 2020; 15(3): 188 - 198

Ayman G. Elnahry*, Ahmed A. Abdel-Kader, Ahmed E. Habib, Gehad A. Elnahry, Karim A. Raafat and Khaled Elrakhawy




Thrombosed External Haemorrhoids: A Clinician’s Dilemma

, 2019; 14(4): 232 - 234

Giuseppe Sammarco, Mario Trompetto and Gaetano Gallo






Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients

, 2018; 13(3): 199 - 209

Rosario Peluso*, Francesco Caso, Marco Tasso, Pasquale Ambrosino, Matteo Nicola Dario Di Minno, Roberta Lupoli, Livio Criscuolo, Paolo Caso, Francesco Ursini, Antonio Del Puente, Raffaele Scarpa and Luisa Costa on behalf of CaRRDs study group




Point-of-Care Lung Ultrasound in Critically ill Patients

, 2018; 13(1): 15 - 26

Gentle S. Shrestha*, Dameera Weeratunga and Kylie Baker





Treating Older HIV-1-infected Subjects With Cobicistat-boosted Darunavir in a 48-week Phase 3 Trial

, 2017; 12(3): 174 - 181

Kimberley Brown*, Brooke Patterson-Browning, Chris Liu, Meera Patel, Lisa Stewart and Richard E. Nettles




Neoadjuvant Therapy for HER2-positive Breast Cancer

, 2017; 12(2): 81 - 92

Rachel Wuerstlein* and Nadia Harbeck




Managing Expectations in the Transition to Proof of Concept Studies

, 2017; 12(2): 111 - 123

Thomas Kieber-Emmons*, Issam Makhoul, Angela Pennisi, Eric R. Siegel, Peter D. Emanuel, Bejotaloh Monzavi-Karbassi, Zenon Steplewski, J. Thaddeus Beck and Laura F. Hutchins




Potential Risks and Mitigation Strategies Before the Conduct of a Clinical Trial: An Industry Perspective

, 2016; 11(1): 47 - 55

Seema Bhagat, Vaibhavi K. Kapatkar, Meenakshi Mourya, Sucheta Roy, Shailendra Jha, Rajasekhar Reddy, Ganesh Kadhe, Amey Mane and Sandesh Sawant






Parallel Conduction of the Phase I Preventive and Therapeutic Trials Based on the Tat Vaccine Candidate

, 2009; 4(3): 195 - 204

S. Bellino, V. Francavilla, O. Longo, A. Tripiciano, G. Paniccia, A. Arancio, V. Fiorelli, A. Scoglio, B. Collacchi, M. Campagna, A. Lazzarin, G. Tambussi, C. Tassan Din, R. Visintini, P. Narciso, A. Antinori, G. D'Offizi, M. Giulianelli, M. Carta, A. Di Carlo, G. Palamara, M. Giuliani, M. E. Laguardia, P. Monini, M. Magnani, F. Ensoli and B. Ensoli





Most Cited Articles


Review Article

Real-world efficacy and safety of pangenotypic direct-acting antivirals against hepatitis C virus infection

, 2019; 14(3): 173-182.

Riccardo Scotto, Antonio Riccardo Buonomo*, Nicola Schiano Moriello, Alberto Enrico Maraolo, Emanuela Zappulo, Biagio Pinchera, Ivan Gentile and Guglielmo Borgia


DOI: 10.2174/1574887114666190306154650


Editorial

Epidemiology of coronavirus disease outbreak: The Italian trends

, 2020; 15(2): 87-92.

Ludovico Abenavoli*, Pietro Cinaglia, Francesco Luzza, Ivan Gentile and Luigi Boccuto


DOI: 10.2174/1574887115999200407143449


Review Article

A concise history of thiopurines for inflammatory bowel disease: From anecdotal reporting to treat-to-target algorithms

, 2019; 14(1): 4-9.

Giovanni Clemente Actis*, Rinaldo Pellicano and Davide Giuseppe Ribaldone


DOI: 10.2174/1574887113666180910120959


Research Article

Effect of chondroitin sulfate on blood serum cytokine profile during carrageenan-induced edema and monoiodoacetate-induced osteoarthritis in rats

, 2019; 14(1): 50-55.

Oleksandr Korotkyi*, Andrii Vovk, Oksana Blokhina, Kateryna Dvorshchenko, Tetyana Falalyeyeva, Ludovico Abenavoli and Liudmyla Ostapchenko


DOI: 10.2174/1574887113666181102111247


Review Article

The role of Biofilm in central venous catheter related bloodstream infections: Evidence-based nursing and review of the literature

, 2020; 15(1): 22-27.

Nicola Ielapi, Emanuela Nicoletti, Carmela Lorè, Giorgio Guasticchi, Tiziana Avenoso, Andrea Barbetta, Stefano de Franciscis, Michele Andreucci, Paolo Sapienza and Raffaele Serra*


DOI: 10.2174/1574887114666191018144739


Systemic Review Article

High flow through nasal cannula in stable and exacerbated chronic obstructive pulmonary disease patients

, 2019; 14(4): 247-260.

Andrea Bruni, Eugenio Garofalo, Gianmaria Cammarota, Paolo Murabito, Marinella Astuto, Paolo Navalesi, Francesco Luzza, Ludovico Abenavoli and Federico Longhini*


DOI: 10.2174/1574887114666190710180540


Editorial

Thrombosed external haemorrhoids: A clinician’s dilemma

, 2019; 14(4): 232-234.

Giuseppe Sammarco, Mario Trompetto and Gaetano Gallo


DOI: 10.2174/1574887114666190927163646


Systemic Review Article

Effect of kangaroo mother care on successful breastfeeding: A systematic review and meta-analysis of randomised controlled trials

, 2019; 14(1): 31-40.

Morteza Ghojazadeh, Sakineh Hajebrahimi, Fatemeh Pournaghi-Azar, Mohammad Mohseni, Naser Derakhshani and Saber Azami-Aghdash*


DOI: 10.2174/1574887113666180924165844


Review Article

Anatomy, physiology and pathophysiology of haemorrhoids

, 2021; 16(1): 75-80.

Francesco Pata*, Alessandro Sgró, Francesco Ferrara, Vincenzo Vigorita, Gaetano Gallo and Gianluca Pellino


DOI: 10.2174/1574887115666200406115150


Review Article

Bedside cardiac pocus in emergency setting: A practice review

, 2020; 15(4): 269-277.

Christian Zanza*, Yaroslava Longhitano, Marco Artico, Gianmaria Cammarota, Andrea Barbanera, Fabrizio Racca, Andrea Audo, Enrico Ravera, Alessio Migneco, Andrea Piccioni and Francesco Franceschi


DOI: 10.2174/1574887115666200802023306


Clinical Trial

Intravenous tranexamic acid for subdural and epidural intracranial hemorrhage: Randomized, double‐blind, placebo-controlled trial

, 2019; 14(4): 286-291.

Pouya Ebrahimi, Javad Mozafari*, Reza Bahrami Ilkhchi, Mohammad Ghasem Hanafi and Maryam Mousavinejad


DOI: 10.2174/1574887114666190620112829


General Review Article

Advanced non-small cell lung cancer with activating epidermal growth factor receptor mutation: First line treatment and beyond

, 2019; 14(2): 120-128.

Danilo Rocco, Ciro Battiloro , Luigi Della Gravara and Cesare Gridelli*


DOI: 10.2174/1574887114666181205155211


Review Article

Stapled surgery for hemorrhoidal prolapse: From the beginning to modern times

, 2021; 16(1): 39-53.

Alessandro Sturiale*, Bernardina Fabiani, Claudia Menconi, Danilo Cafaro, Felipe Celedon Porzio and Gabriele Naldini


DOI: 10.2174/1574887115666200310164519


Research Article

Do we have another option to treat bleeding hemorrhoids? The emborrhoid technique: Experience in 16 patients

, 2021; 16(1): 81-86.

Elisabetta Moggia*, Giuseppina Talamo, Gaetano Gallo, Angelo Bianco, Matteo Barattini, Giancarlo Salsano, Daniele Zefiro, Teseo Stefanini and Stefano Berti


DOI: 10.2174/1574887115666200313102246



Most Accessed Articles

Impact of Covid-19 on Mental Health: An Overview

, 2021; 16(3): 227-231.

Minal M. Kshirsagar*, Arun S. Dodamani, Girija A. Dodamani, Vrushali R. Khobragade and Rahul N. Deokar


DOI: 10.2174/1574887115666210105122324


Review and Analysis of Massively Registered Clinical Trials of COVID-19 using the Text Mining Approach

, 2021; 16(3): 242-257.

Swayamprakash Patel*, Ashish Patel, Mruduka Patel, Umang Shah, Mehul Patel, Nilay Solanki and Suchita Patel


DOI: 10.2174/1574887115666201202110919


The Clinical Difference between Gabapentin and Pregabalin: Data from a Pilot Comparative Trial

, 2021; 16(3): 279-287.

Omar Gammoh*, Ahmed Al-Smadi, Mohammad Q. Shawagfeh, Thani Abadi, Jawad Kasawneh, Sukaina Malkawi and Sima Zein


DOI: 10.2174/1574887116666210201110507


Intravenous Magnesium – Lidocaine - Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy

, 2021; 16(3): 288-293.

Christian Zanza*, Yaroslava Longhitano, Edwin Lin, Jerry Luo, Marco Artico, Benedetta Savarese, Valeria Bonato, Andrea Piccioni, Francesco Franceschi, Samanta Taurone, Ludovico Abenavoli and Jack Marshall Berger


DOI: 10.2174/1574887115666201202105620


COVID-19 and Clinical Trials: Current Challenges and Future Directions

, 2021; 16(3): 258-261.

Vinay Singh*, Sandeep Garg, Monika Klimek, Rajeev Ranjan Sinha and Dinesh Dhanwal


DOI: 10.2174/1574887116666210122160705


SARS-CoV-2 Spread Dynamics in Italy: The Calabria Experience

, 2021; 16(3): 309-315.

Ludovico Abenavoli*, Pietro Cinaglia, Anna Caterina Procopio, Raffaele Serra, Isabella Aquila, Christian Zanza, Yaroslava Longhitano, Marco Artico, Tiziana Larussa, Luigi Boccuto, Pietrantonio Ricci and Francesco Luzza


DOI: 10.2174/1574887116666210401124945


Prevalence and Related Factors of Sarcopenia in Community-dwelling Elderly with Long-term Care Insurance

, 2021; 16(3): 335-340.

Masahiro Kitamura, Kazuhiro P. Izawa*, Kodai Ishihara, Hiroaki Matsuda, Soichiro Okamura and Koji Fujioka


DOI: 10.2174/1574887116666210211144446


Infection, Infectious Agents and Vascular Disease

, 2021; 16(3): 262-271.

Nicola Ielapi, Francesco Caprino, Biagio Malizia, Antonio Sisinni, Lwanga Ssempijja, Michele Andreucci, Noemi Licastro and Raffaele Serra*


DOI: 10.2174/1574887116666210325124045


Pathogenetic Correction of the Enteric Insufficiency Syndrome in Patients with Advanced Peritonitis

, 2021; 16(3): 272-278.

Fedor N. Ilchenko, Sergey G. Grivenko, Igor V. Kaminsky, Yuriy V. Artemov, Evelina R. Kondratiuk, Vitalii B. Kaliberdenko, Shanmugaraj Kulanthaivel* and Keerthanaa Balasundaram


DOI: 10.2174/1574887115666201228151727


Epidemiological Characteristics of 64 Covid-19 Patients in Errachidia Province (Darâa-Tafilalet region), Morocco: A Retrospective Analysis

, 2021; 16(3): 294-302.

Mourad Akdad, Youness Algharrass, Hafid Talha, Abdelaadim Babakhouya, Mohammed Ajebli, Ahlam Ech-cherrate and Mohamed Eddouks*


DOI: 10.2174/1574887116666210114161633



Management of Leaks Following Laparoscopic Sleeve Gastrectomy Using Specifically Designed Large Covered Metal Stents

, 2021; 16(3): 303-308.

Carmelo Luigiano*, Milena Di Leo, Leonardo Henry Eusebi, Matteo Barabino, Enrico De Nicola, Marco Giovenzana, Enrico Opocher, Giuseppe Iabichino, Maria Angela Palamara, Giuseppa Giacobbe, Andrea Tortora, Clara Virgilio, Ludovico Abenavoli, Socrate Pallio and Pierluigi Consolo


DOI: 10.2174/1574887116666210204142417


Phase 1 Clinical Trials of Small Molecules: Evolution and State of the Art

, 2021; 16(3): 232-241.

John J. Sramek, Michael F. Murphy, Sherilyn Adcock, Jeffrey G. Stark and Neal R. Cutler*


DOI: 10.2174/1574887116666210204125844


Effectiveness and Safety of A Nutraceutical Formulation for the Treatment of Functional Dyspepsia in Primary Care

, 2021; 16(3): 329-334.

Antonio Tursi*, Marcello Picchio, Walter Elisei, Leonardo Allegretta, Pierluigi Benedicenti, Fabrizio Bossa, Simone Di Bella, Antonio Elefante, Stefano Gallina, Federica Greco, Francesco Maurichi, Antonio Pio Palieri, Antonio Penna, Giuseppe Pranzo, Giovanni Luca Rizzo, Giovanni Brandimarte, Ludovico Abenavoli, Maria Santa Alfieri, Natale Antonino, Carlo Autorino, Pasquale Bellomo, Carlo Casamassima, Basilio Paolo Colucci, Vincenzo De Cristofaro, Rocco Demauro, Pietro Derenzio, Francesco Detommasi, Michele Fazio, Vincenzo Ferrari, Alessio Gallo, Donatella Greco, Vito Lisco, Francesco Lore, Michele Manfredi, Giorgio Marsano, Pasquale Mascoli, Luigi Mazzilli, Giovanni Messa, Giulio Minoretti, Pasquale Misciagna, Francesco Monterisi, Saverio Nappi, Anna Rosa Resta, Pasquale Saponaro, Giovanni Sbarra, Salvatore Scutifero, Vincenzo Selvaggio, Giuseppe Sica, Mario Tarallo, Giancarlo Torelli, Costantino Vigilante and Pasquale Zecchillo


DOI: 10.2174/1574887116666210612034911


Does Proctologic Surgery Really Influence Sexual Behaviors?

, 2021; 16(3): 322-328.

Alessandro Sturiale *, Bernardina Fabiani , Raad Dowais , Felipe Celedon Porzio, Gaetano Gallo, Jacopo Martellucci, Claudia Menconi , Riccardo Morganti and Gabriele Naldini


DOI: 10.2174/1574887116666210526125202




Editor-in-Chief

graphic
Ludovico Abenavoli
Department of Health Sciences
University Magna Graecia
Catanzaro
(Italy)
Biography
View Full Editorial Board

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Journal History

Reviews on Recent Clinical Trials Journal was launched in 2006. Dr. Ludovico Abenavoli serves as the Editor-in-Chief of the journal.

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