SARS-CoV-2: Possible Factors Contributing to Serious Consequences of COVID-19?
Ruqaiyyah Siddiqui1, Mohammad R. Mungroo2, Mohamed Y. Abouleish1, Naveed A. Khan2, *
1 College of Arts and Sciences, American University of Sharjah, Sharjah, UAE
2 Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE
Background and Objectives:
The recently discovered coronavirus, SARS-CoV-2 has infected over 170 million people (as of 31th May 2021) since it was elucidated in December 2019. The number of SARS-CoV-2 cases and mortality rates vary from country to country, and unfortunately, the United Kingdom ranks in the top 5 countries with the most deaths as of 31th May 2021.
A literature review was conducted during May 2021 to examine if factors such as gut microbiome, ethnic diversity, high cancer rates, obesity and alcohol consumption may have contributed to the higher number of cases and mortality due to SARS-CoV-2 in the UK.
The western diet is associated with a less diverse gut microbiome, as well as obesity, and contributes to the severity of SARS-CoV-2 infection. Moreover, people belonging to Black and South Asian ethnic groups in the UK have an increased risk of death due to SARS-CoV-2 infection. Given the high number of cancer patients in the UK, as well as excess consumption of alcohol, higher mortality rates were observed, most likely due to people possessing a less diverse gut microbiome and/or weakened immune system.
Targeting the gut microbiome in developing potential therapeutics against SARS-CoV-2 is of value, and further studies are needed to understand the specific role of the gut microbiome.
Keywords: Severe acute respiratory syndrome, Coronavirus, Cancer, Ethnicity, Obesity, Gut microbiome.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
* Address correspondence to this author at the Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah PO Box 27272, UAE; Tel: +971-6505-7722; E-mail: firstname.lastname@example.org
Abdullah Shehab Emirates Cardiac Society Emirates Medical Association Dubai (United Arab Emirates) Biography
Biography of Abdullah Shehab
Dr. Abdullah Shehab has 22 years of experience in Internal medicine, cardiology and interventional cardiology and medical education. Currently, he serves as the General Secretary of Emirates Cardiac Society and Vice President of Gulf Intervention Society. He is a Fellow of royal college of physicians UK, American college of physician, European society of cardiology, American college of cardiology, American society of cardiac intervention and fellow of the American heart association. Professor Shehab is the Chief Editor of Emirates Medical Journal and also serves as Editor in many other regional and international journals. Dr. Shehab has published 149 paper in Medline. His research interest includes: Heart failure, Coronary artery disease, Dyslipidaemia, Hypertension, Arrhythmias, Cardiac intervention, Cardiac imaging, Screening for cardiac disease in sport players, cardiovascular disease in pregnancy.