Contents

Medicinal Chemistry, Volume 8 - Number 6

Selective Inhibition of Inducible Nitric Oxide Synthase by Derivatives of Acetamidine

, 8(6): 991 - 995

Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca and Rosa Amoroso


DOI: 10.2174/1573406411208060991




Transient Injury-Dependent Up-Regulation of CD105 and its Specific Targeting with an Anti-Vascular Anti-Mouse Endoglin-Nigrin b Immunotoxin

, 8(6): 996 - 1002

Raquel Munoz, Yolanda Arias, Jose Miguel Ferreras, Pilar Jimenez, Maria Angeles Rojo, Carmelo Bernabeu, Damian Cordoba-Diaz and Tomas Girbes


DOI: 10.2174/1573406411208060996




Antimitotic Activity on Sea Urchin Embryonic Cells of Seven Antiparasitic Morita-Baylis-Hillman Adducts: A Potential New Class of Anticancer Drugs

, 8(6): 1003 - 1011

Jocelmo C. A. Leite, Claudio G. L. Junior, Fabio P. L. Silva, Suervy C.O. Sousa, Mario L. A. A. Vasconcellos and Luis F. Marques-Santos


DOI: 10.2174/1573406411208061003




Synthesis, SAR and Biological Evaluation of Natural and Non-natural Hydroxylated and Prenylated Xanthones as Antitumor Agents

, 8(6): 1012 - 1025

Xiaojin Zhang, Xiang Li, Suofu Ye, Yu Zhang, Lei Tao, Yuan Gao, Dandan Gong, Meiyang Xi, Huyan Meng, Mingqian Zhang, Wenlei Gao, Xiaoli Xu, Qinglong Guo and Qidong You


DOI: 10.2174/1573406411208061012




Enhancement of Antitumor Effects of a New Boron Compound Combined with Ultrasound on the Mouse Ascites Tumor

, 8(6): 1026 - 1031

Pradip Ghosh, Pratima Sur and Saswati P. Bag


DOI: 10.2174/1573406411208061026




Impact of Clozapine, N-Desmethylclozapine and Chlorpromazine on Thromboxane Production in Vitro

, 8(6): 1032 - 1038

Hubertus Himmerich, Luise Schmidt, Susen Becker, Linda Kortz, Jeremias Schonherr, Roland Mergl, Katrin Bauer, Ulrich Sack, Abigail J. Sheldrick, Joachim Thiery and Uta Ceglarek


DOI: 10.2174/1573406411208061032




Synthesis and Biological Evaluation of New Sulfonamide Derivatives as Potential Anti-Trypanosoma cruzi Agents

, 8(6): 1039 - 1044

Virgilio Bocanegra-Garcia, Juan Carlos Villalobos-Rocha, Benjamin Nogueda-Torres, Maria Edith Lemus- Hernandez, Argelia Camargo-Ordonez, Ninfa Maria Rosas-Garcia and Gildardo Rivera


DOI: 10.2174/1573406411208061039




Molecular Features for Antitrypanosomal Activity of Thiosemicarbazones Revealed by OPS-PLS QSAR Studies

, 8(6): 1045 - 1056

Norka Beatriz Huaman Lozano, Vinicius Goncalves Maltarollo, Karen Cacilda Weber, Kathia Maria Honorio, Rafael Victorio Carvalho Guido, Adriano Defini Andricopulo and Alberico Borges Ferreira Da Silva


DOI: 10.2174/1573406411208061045




Structure-Based Design, Synthesis and Molecular Modeling Studies of Thiazolyl Urea Derivatives as Novel Anti-Parkinsonian Agents

, 8(6): 1057 - 1068

Faizul Azam, Medapati Vijaya Vara Prasad, Neelaveni Thangavel, Anil Kumar Shrivastava and Govind Mohan


DOI: 10.2174/1573406411208061057




Design, Synthesis, Pharmacological Evaluation and Descriptor Based Similarities Study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1- yl]acetamides as Potential Antipsychotics

, 8(6): 1069 - 1075

Radha Charan Dash, Sharad H. Bhosale, Suhas M. Shelke, Mugdha R. Suryawanshi and Kakasaheb R. Mahadik


DOI: 10.2174/1573406411208061069




Design, Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted –[1,2,4]-Triazolo[4,3-f]Pyrimidine Derivatives

, 8(6): 1076 - 1083

Li-Ping Guan, Xin Sui, Yue Chang, Zheng-Shun Yan, Guo-Zhong Tong and You-Le Qu


DOI: 10.2174/1573406411208061076




Homology Modeling and Antagonist Binding Site Study of the Human Histamine H2 Receptor

, 8(6): 1084 - 1092

Jing Zhang, Tao Qi and Jing Wei


DOI: 10.2174/1573406411208061084




Synthesis of 2-(4-substitutedbenzylpiperazin-1-yl)-N-(2-oxo-2,3-dihydrobenzooxazol- 6-yl)acetamides as Inotropic Agents

, 8(6): 1093 - 1098

Tianyi Zhang, Liangpeng Sun, Xuekun Liu, Xun Cui and Huri Piao


DOI: 10.2174/1573406411208061093




3D-QSAR and Docking Studies on a Series of Benzothiadiazine Derivatives as Genotype 1 HCV Polymerase Inhibitors

, 8(6): 1099 - 1107

Vaishali M. Patil, Satya Prakash Gupta, Subeer Samanta and Neeraj Masand


DOI: 10.2174/1573406411208061099




QSAR Study On 5-Lipoxygenase Inhibitors Based on Support Vector Machine

, 8(6): 1108 - 1116

Bing Niu, Qiang Su, Xiaochen Yuan, Wencong Lu and Juan Ding


DOI: 10.2174/1573406411208061108




3D QSAR Pharmacophore Modeling for c-Met Kinase Inhibitors

, 8(6): 1117 - 1125

Dandan Huang, Xiaoyun Zhu, Chunlei Tang, Yicheng Mei, Wei Chen, Baowei Yang, Jing Han, Hai Qian and Wenlong Huang


DOI: 10.2174/1573406411208061117




Design, Synthesis and Antihistamine Evaluations of Several N-hydroxyalkyl Desloratadine Analogues

, 8(6): 1126 - 1132

Yan Lin, Yue Wang, Li-feng Sima, Dong-hua Wang, Li-gong Chen and Lei Li


DOI: 10.2174/1573406411208061126




Identification of Small Molecule Sulfonic Acids as Ecto-5'-Nucleotidase Inhibitors

, 8(6): 1133 - 1139

Rabia Raza, Aamer Saeed, Joanna Lecka, Jean Sevigny and Jamshed Iqbal


DOI: 10.2174/1573406411208061133




Looking for New Targets: Simple Coumarins as Antibacterial Agents

, 8(6): 1140 - 1145

Maria Joao Matos, Saleta Vazquez-Rodriguez, Lourdes Santana, Eugenio Uriarte, Cristina Fuentes-Edfuf, Ysabel Santos and Angeles Munoz-Crego


DOI: 10.2174/1573406411208061140




New Cathepsin D Inhibitor Library Utilizing Hydroxyethyl Isosteres with Cyclic Tertiary Amines

, 8(6): 1146 - 1154

Rose M. McConnell, Kalyani Inapudi, Naveen Kadasala, Karthika Yarlagadda, Priya Velusamy, Matthew S. McConnell, Adam Green, Carol Trana, Kelley Sayyar and James S. McConnell


DOI: 10.2174/1573406411208061146




In Silico Prediction of Novel Inhibitors of the DNA Binding Activity of FoxG1

, 8(6): 1155 - 1162

Syam Bhuvanachandran Nair, Shaik Mahammad Abdul Fayaz and Rajanikant Golgodu Krishnamurthy


DOI: 10.2174/1573406411208061155




Evaluating the Diagnostic and Chemotherapeutic Potential of Vancomycin- Derived Imaging Conjugates

, 8(6): 1163 - 1170

Sumbla Sheikh, Alexander Sturzu, Uwe Klose, Hartmut Echner, Martin Deeg, Thomas Nagele, Marius Horger, Christian Schwentner, Ulrike Ernemann, Wolfgang Voelter and Stefan Heckl


DOI: 10.2174/1573406411208061163




Multiple Lipid-lowering Treatment in Pediatric Patients with Hyperlipidemia

, 8(6): 1171 - 1181

Claudia Stefanutti and Fabio Mazza


DOI: 10.2174/1573406411208061171




Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls

, 8(6): 1182 - 1189

Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli and Raffaele Giubbini


DOI: 10.2174/1573406411208061182




Synthesis, Crystal Structure and Anti-HIV Activity of 2- Adamantyl/adamantylmethyl-5-aryl-1,3,4-oxadiazoles

, 8(6): 1190 - 1197

Mahmood-ul-Hassan Khan, Tashfeen Akhtar, Najim A. Al-Masoudi, Helen Stoeckli-Evans and Shahid Hameed


DOI: 10.2174/1573406411208061190




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