Contents

Medicinal Chemistry, Volume 8 - Number 5

A TRIBUTE TO A LIVING LEGEND (Special Issue in Honor of the 70th Birthday of Dr. Atta-ur-Rahman.)

, 8(5): i

William J. Hoekstra, Andreas Hilgeroth, Kuo-Chen Chou, Istvan Toth, Adam McCluskey, Ming-Rong Zhang and Paul Cos


DOI: 10.2174/157340641120805000i




Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

, 8(5): 769 - 778

Silvia Franchini, Annalisa Tait, Claudia Sorbi and Livio Brasili


DOI: 10.2174/157340612802084162




Synthesis and In Vitro Biological Evaluation of Novel Pyrazole Derivatives as Potential Antitumor Agents

, 8(5): 779 - 788

Michael S. Christodoulou, Nikolas Fokialakis, Sangkil Nam, Richard Jove, Alexios-Leandros Skaltsounis and Serkos A. Haroutounian


DOI: 10.2174/157340612802084252




Semi-synthesis of 1-Deoxypaclitaxel and its Analogues from 1-Deoxybaccatin VI

, 8(5): 789 - 798

Dan-Hui Jin, Yong-Mei Cui and Hai-Xia Lin


DOI: 10.2174/157340612802084379




Synthesis and Immunomodulation of Human Lymphocyte Proliferation and Cytokine (Interferon-γ) Production of Four Novel Leflunomide Analogues

, 8(5): 799 - 804

Seyed Adel Moalem, Farzin Hadizadeh, Elham Saber Farimani, Maryam Rameshrad and Maryam Allahyari


DOI: 10.2174/157340612802084180




Poly (D,L-lactic-co-glycolide) Nanoparticles for the Improved Therapeutic Efficacy of All-trans-retinoic Acid: A Study of Acute Myeloid Leukemia (AML) Cell Differentiation In Vitro

, 8(5): 805 - 810

Aswathy Mary Simon, Sankar Jagadeeshan, Emimol Abraham, Ashalatha Akhilandeshwaran, Jisha J. Pillai, Nisha Asok Kumar, Asha Nair Sivakumari and Gopalakrishnapillai Sankaramangalam Vinod Kumar


DOI: 10.2174/157340612802084333




The Efficacy of Conceptual DFT Descriptors and Docking Scores on the QSAR Models of HIV Protease Inhibitors

, 8(5): 811 - 825

Hemant Kumar Srivastava, Chinmayee Choudhury and G. Narahari Sastry


DOI: 10.2174/157340612802084351




Hexapeptide Functionality of Cellulose as NS3 Protease Inhibitors

, 8(5): 826 - 830

Medhat Ibrahim, Noha A. Saleh, Wael M. Elshemey and Anwar A. Elsayed


DOI: 10.2174/157340612802084144




Anti HIV-1 Agents 6. Synthesis and Anti-HIV-1 Activity of Indolyl Glyoxamides

, 8(5): 831 - 833

Yi Wang, Ning Huang, Xiang Yu, Liu-Meng Yang, Xiao-Yan Zhi, Yong-Tang Zheng and Hui Xu


DOI: 10.2174/157340612802084270




Synthesis, Characterization, Biological Evaluation and Docking of Coumarin Coupled Thiazolidinedione Derivatives and its Bioisosteres as PPARγ Agonists

, 8(5): 834 - 845

Shubhanjali Shukla, Pankaj Kumar, Nirupam Das, N.S. Hari Narayana Moorthy, Sushant Kumar Shrivastava, Piyush Trivedi and Radhey Shyam Srivastava


DOI: 10.2174/157340612802084388




Metronidazole Esters: A New Class of Antiglycation Agents

, 8(5): 846 - 852

Aurang Zeb, Imran Malik, Saima Rasheed, Muhammad Iqbal Choudhary and Fatima Z. Basha


DOI: 10.2174/157340612802084360




In silico Based Structural Analysis of Some Piperidine Analogs as Farnesyltransferase Inhibitors

, 8(5): 853 - 864

Narayana Subbiah Hari Narayana Moorthy, Sergio F. Sousa, Maria J. Ramos and Pedro A. Fernandes


DOI: 10.2174/157340612802084171




Design, Synthesis and Anti-itch Activity Evaluation of Aromatic Amino Acid Derivatives as Gastrin-Releasing Peptide Receptor Antagonists

, 8(5): 865 - 873

Ri-Sheng Yao, Ting-Ting Li, Jun Xu, Lai-En Jiang and Ban-Feng Ruan


DOI: 10.2174/157340612802084342




Synthesis of 5,6-Dichloroindan-1-Acids and their Tetrazolyl Derivatives as Analgesic and Anti-inflammatory Agents

, 8(5): 874 - 882

Rajib Kumar Pal, Hasina Yasmin, Lutfun Nahar, Bidyut Kanti Datta, Abul Kalam Azad Chowdhury, Joydeb Kumar Kundu, Sitesh Chandra Bachar and Satyajit Dey Sarker


DOI: 10.2174/157340612802084234




Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase β

, 8(5): 883 - 893

Alexandra Zakharenko, Dmitry Sokolov, Olga Luzina, Maria Sukhanova, Svetlana Khodyreva, Olga Zakharova, Nariman Salakhutdinov and Olga Lavrik


DOI: 10.2174/157340612802084225




3D QSAR Pharmacophore, CoMFA and CoMSIA Based Design and Docking Studies on Phenyl Alkyl Ketones as Inhibitors of Phosphodiesterase 4

, 8(5): 894 - 912

Anand Gaurav and Ranjit Singh


DOI: 10.2174/157340612802084298




Quantifying the Structural Requirements for Designing Newer FLT3 Inhibitors

, 8(5): 913 - 927

Rajiv Kumar Kar, Priyanka Suryadevara, Rajesh Roushan, Ganesh Chandra Sahoo, Manas Ranjan Dikhit and Pradeep Das


DOI: 10.2174/157340612802084153




Ligustrazine Derivatives. Part 6: Design, Synthesis and Evaluation of Novel Ligustrazinyl Acylguanidine Derivatives as Potential Cardiovascular Agents

, 8(5): 928 - 933

Zhenyu Li, Fang Yu, Lei Cui, Peng Zhan, Shouxun Wang, Yuemao Shen and Xinyong Liu


DOI: 10.2174/157340612802084243




Anti-diabetic Effect of Ginsenoside Rb3 in Alloxan-induced Diabetic Mice

, 8(5): 934 - 941

Qi Tao Bu, Wei Yun Zhang, Quan Cheng Chen, Cheng Zhong Zhang, Xiao Jie Gong, Wen Cong Liu, Wei Li and Yi Nan Zheng


DOI: 10.2174/157340612802084199




Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2DQuantitative Structure-Activity Relationships

, 8(5): 942 - 946

Alina Ghinet, Amaury Farce, Souhila Oudir, Jean Pommery, Joseph Vamecq, Jean-Pierre Henichart, Benoit Rigo and Philippe Gautret


DOI: 10.2174/157340612802084216




Biological Evaluation of Mechlorethamine-Pt(II) Complex, Part II: Antimicrobial Screening and Lox Study of the Complex and its Ligand

, 8(5): 947 - 952

Ivana D. Radojevic, Zorica D. Petrovic, Ljiljana R. Comic, Dusica Simijonovic, Vladimir P. Petrovic and Dimitra Hadjipavlou-Litina


DOI: 10.2174/157340612802084315




Design, Synthesis and Protection Against Pentylenetetrazole-induced Seizure of N-aryl Derivatives of the Phthalimide Pharmacophore

, 8(5): 953 - 963

Asghar Davood, Hamed Shafaroodi, Mohsen Amini, Alireza Nematollahi, Mehrshad Shirazi and Maryam Iman


DOI: 10.2174/157340612802084289




Synthesis, Antidiabetic and Hypolipidemic Activities of New Diethylamine and Triethoxysilyl Derivatives of Tolbutamide on Rats

, 8(5): 964 - 969

Abbas Ahmadi, Mohsen Khalili, Seyedsobhan Seyedhoseyni, Ehsan Maadi Roudsari and Babak Nahri-Niknafs


DOI: 10.2174/157340612802084261




Design of Novel Dihydroxynaphthoic Acid Inhibitors of Plasmodium Falciparum Lactate Dehydrogenase

, 8(5): 970 - 984

Eugene Megnassan, Melalie Keita, Cecile Bieri, Akori Esmel, Vladimir Frecer and Stanislav Miertus


DOI: 10.2174/157340612802084324




A Novel and Facile Synthetic Approach for Tasigna

, 8(5): 985 - 989

Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang


DOI: 10.2174/157340612802084207




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