Contents

Medicinal Chemistry, Volume 8 - Number 4

Editorial [Hot Topics: New Trends in Micro- and Nano-systems Development for Pharmaceutical Actives Release]

, 8(4): 515

Lucia Martin-Banderas


DOI: 10.2174/157340612801216229




Synthesis of a Biodegradable Magnetic Nanomedicine Based on the Antitumor Molecule Tegafur

, 8(4): 516 - 523

Jose L. Arias, Eva Saez-Fernandez, Margarita Lopez-Viota, Rafael A. Biedma-Ortiz and Mª Adolfina Ruiz


DOI: 10.2174/157340612801216373




Monodisperse Nanoparticles from Self-Assembling Amphiphilic Cyclodextrins: Modulable Tools for the Encapsulation and Controlled Release of Pharmaceuticals

, 8(4): 524 - 532

Alejandro Mendez-Ardoy, Marta Gomez-Garcia, Annabelle Geze, Jean-Luc Putaux, Denis Wouessidjewe, Carmen Ortiz Mellet, Jacques Defaye, Jose M. Garcia Fernandez and Juan M. Benito


DOI: 10.2174/157340612801216265




Use of Flow Focusing® Technology to Produce Tobramycin-Loaded Plga Microparticles for Pulmonary Drug Delivery

, 8(4): 533 - 540

Lucia Martin-Banderas, Maria Angeles Holgado, Josefa Alvarez-Fuentes and Mercedes Fernandez- Arevalo


DOI: 10.2174/157340612801216409




Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone

, 8(4): 541 - 548

Hierrezuelo Jesus, Benavente Juana, Lopez–Romero Juan Manuel, Martinez de Yuso Maria del Valle and Rodriguez–Castellon Enrique


DOI: 10.2174/157340612801216238




Editorial [Hot Topic: Calcium Metabolism and Treatment of Hypercalcemia]

, 8(4): 549 - 550

Franco Lumachi


DOI: 10.2174/157340612801216175




Diagnosis of Alterations of Serum Calcium Metabolism

, 8(4): 551 - 555

Franco Lumachi, Piero Cappelletti, Renato Tozzoli, Stafano M.M. Basso, Giovanni Luisetto and Valentina Camozzi


DOI: 10.2174/157340612801216139




Treatment of Chronic Hypercalcemia

, 8(4): 556 - 563

Valentina Camozzi, Giovanni Luisetto, Stefano M.M. Basso, Piero Cappelletti, Renato Tozzoli and Franco Lumachi


DOI: 10.2174/157340612801216355




Treatment of Acute Hypercalcemia

, 8(4): 564 - 568

Stafano M.M. Basso, Franco Lumachi, Fabiana Nascimben, Giovanni Luisetto and Valentina Camozzi


DOI: 10.2174/157340612801216382




New Adamantane Derivatives with Sigma Affinity and Antiproliferative Activity

, 8(4): 569 - 586

Stefanos Riganas, Ioannis Papanastasiou, George B. Foscolos, Andrew Tsotinis, Kostas Dimas, Vassilios N. Kourafalos, Andreas Eleutheriades, Vassilios I. Moutsos, Humaira Khan, Prassa Margarita, Stavroula Georgakopoulou, Angeliki Zaniou, Maria Theodoropoulou, Athanasios Mantelas, Stavroula Pondiki and Alexandre Vamvakides


DOI: 10.2174/157340612801216201




Design, Synthesis and Antiproliferative Activity of 2-Acetamidothiazole-5- carboxamide Derivatives

, 8(4): 587 - 594

Wukun Liu, Jinpei Zhou, Yu Zheng, Fan Qi, Huibin Zhang, Hai Qian, Jing Wang, Yanhua Cheng and Ronald Gust


DOI: 10.2174/157340612801216418




Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1- yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo

, 8(4): 595 - 598

Lianbao Ye, Xiaomin Ou, Xuedong Peng and Yan Luo


DOI: 10.2174/157340612801216157




A QSAR Analysis of 2-phenoxy-N-substituted Acetamide Analogues as Hypoxia-Inducible Factor-1(HIF-1) Inhibitors: A Rational Approach to Anticancer Drug Design

, 8(4): 599 - 614

Malleshappa N. Noolvi, Harun M. Patel and Sarita Kamboj


DOI: 10.2174/157340612801216274




Differences in Vanadocene Dichloride and Cisplatin Effect on MOLT-4 Leukemia and Human Peripheral Blood Mononuclear Cells

, 8(4): 615 - 621

Radim Havelek, Pavel Siman, Jana Cmielova, Alena Stoklasova, Jirina Vavrova, Jaromir Vinklarek, Jiri Knizek and Martina Rezacova


DOI: 10.2174/157340612801216364




The Preformulation Stability Studies of a Proline Prodrug of Methotrexate

, 8(4): 622 - 628

Ann Stephenson, Zhiqian Wu and Xudong Yuan


DOI: 10.2174/157340612801216166




Synthesis, In Vitro and In Silico NS5B Polymerase Inhibitory Activity of Benzimidazole Derivatives

, 8(4): 629 - 635

Vaishali M. Patil, Gurukumar K. R., Maksim Chudayeu, Satya Prakash Gupta, Subeer Samanta, Neeraj Masand and Neerja Kaushik-Basu


DOI: 10.2174/157340612801216120




Structural Insight for Imidazopyridazines as Malarial Kinase PfPK7 Inhibitors Using QSAR Techniques

, 8(4): 636 - 648

Nitendra K. Sahu and D. V. Kohli


DOI: 10.2174/157340612801216300




A QSAR Study on a Series of Pyrrole Derivatives Acting as Lymphocyte- Specific Kinase (Lck) Inhibitors

, 8(4): 649 - 655

Zaihra Anwer and Satya P. Gupta


DOI: 10.2174/157340612801216319




A QSAR Study on Novel Series of Carbonic Anhydrase Inhibitors hCA IX—Tumor-Associated (Hypoxia)

, 8(4): 656 - 672

Shalini Singh


DOI: 10.2174/157340612801216391




Computational Approaches to Improve Aggrecanase-1 Inhibitory Activity of (4-keto) Phenoxy) Methyl Biphenyl-4-sulfonamide: Group Based QSAR and Docking Studies

, 8(4): 673 - 682

Ponnurengam Malliappan Sivakumar, Naga Vignesh Selvaraj, G. Ramesh, J. Mohanapriya, Veluchamy Prabhawathi and Mukesh Doble


DOI: 10.2174/157340612801216247




Synthesis and Biological Evaluation of Naloxone and Naltrexone-Derived Hybrid Opioids

, 8(4): 683 - 689

Bahman E. Nassim and Ming-Lei Wang


DOI: 10.2174/157340612801216193




In vitro Synergy Testing of Anidulafungin with Fluconazole, Tioconazole, 5-Flucytosine and Amphotericin B against some Candida spp.

, 8(4): 690 - 698

Antonio Rosato, Monica Piarulli, Brigida Immacolata Pia Schiavone, Maria Teresa Montagna, Giuseppina Caggiano, Marilena Muraglia, Addolorata Carone, Carlo Franchini and Filomena Corbo


DOI: 10.2174/157340612801216184




Synthesis of Novel 4-Aryl-1,2,3,4-tetrahydroisoquinolines as Probes for Dopamine Receptor Ligands

, 8(4): 699 - 704

Gianfabio Giorgioni, Dario Ambrosini, Giovanni Filippo Palmieri, Barbara Costa, Antonio Di Stefano and Claudia Martini


DOI: 10.2174/157340612801216292




Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers

, 8(4): 705 - 710

Khalid Mohammed Khan, Muhammad Taha, Farzana Naz, Salman Siddiqui, Sajjad Ali, Fazal Rahim, Shahnaz Perveen and M. Iqbal Choudhary


DOI: 10.2174/157340612801216111




Synthesis and Biological Evaluation of a Series of 6,7-dimethoxy-1-(3,4- dimethoxybenzyl)-2-substituted Tetrahydroisoquinoline Derivatives

, 8(4): 711 - 716

Zhi-hong Zou, Xiao-bu Lan, Chun-lei Tang, Xiao-yun Zhu, Bao-min Liu, Hai Qian, Wen-long Huang and Yun-man Li


DOI: 10.2174/157340612801216337




A QSAR Study of Biphenyl Analogues of 2-Nitroimidazo-[2, 1-b] [1, 3] - oxazines as Antitubercular Agents Using Genetic Function Approximation

, 8(4): 717 - 726

Supratim Ray and Partha Pratim Roy


DOI: 10.2174/157340612801216210




Synthesis and 188Re Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate

, 8(4): 727 - 731

Wei Cui, Yuanqing Zhang, Xiaoping Xu and Yu-Mei Shen


DOI: 10.2174/157340612801216256




In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2- carboxylates

, 8(4): 732 - 741

Martin Kratky, Jarmila Vinsova and Vladimir Buchta


DOI: 10.2174/157340612801216346




Design, Synthesis and Multidrug Resistance Reversal Activity Evaluation of 8-Oxocoptisine Derivatives

, 8(4): 742 - 748

Jian Bo Wu, Fan Lei, Xiang Juan Cui, Yun He, Li Hai, Juan Zhang and Yong Wu


DOI: 10.2174/157340612801216148




Serum Specific Vasopressin-Degrading Activity is Related to Blood Total Cholesterol Levels in Men but not in Women

, 8(4): 749 - 752

Ramirez-Exposito Maria Jesus, Arrazola Marcelina, Carrera-Gonzalez Maria Pilar, Arias de Saavedra Jose Manuel, Sanchez-Agesta Rafael, Mayas Maria Dolores and Martinez-Martos Jose Manuel


DOI: 10.2174/157340612801216328




Prodrug Strategies in Ocular Drug Delivery

, 8(4): 753 - 768

Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi and Ashim K. Mitra


DOI: 10.2174/157340612801216283




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