Contents

Medicinal Chemistry, Volume 8 - Number 3

Application of Artificial Neural Networks for the Prediction of Antitumor Activity of a Series of Acridinone Derivatives

, 8(3): 309 - 319

Marcin Koba


DOI: 10.2174/157340612800786651




Synthesis and Biological Evaluation of 3΄-C-Ethynyl and 3΄-C-(1,4-disubstituted-1,2,3-triazolo) Double-Headed Pyranonucleosides

, 8(3): 320 - 329

Christos Kiritsis, Stella Manta, Ioannis Papasotiriou, Evdoxia Coutouli-Argyropoulou, Sakellarios Trakossas, Jan Balzarini and Dimitri Komiotis


DOI: 10.2174/157340612800786624




Substituted Urea Derivatives: A Potent Class of Antidepressant Agents

, 8(3): 330 - 336

Shahnaz Perveen, Sana Mustafa, Muhammad A. Khan, Ahsana Dar, Khalid M. Khan and Wolfgang Voelter


DOI: 10.2174/157340612800786615




A New Class of Anticonvulsants Possessing 6 Hz Psychomotor Seizure Test Activity: 2-(1H-Benzotriazol-1-yl)-N'-[Substituted] Acetohydrazides

, 8(3): 337 - 348

Praveen Kumar and Laxmi Tripathi


DOI: 10.2174/157340612800786606




SAR Analysis of New Dual Targeting Fluoroquinolones. Implications of the Benzenesulfonyl Group

, 8(3): 349 - 360

Marcelo J. Nieto, Adriana B. Pierini, Nidhi Singh, Christopher R. McCurdy, Ruben H. Manzo and aria R. Mazzieri


DOI: 10.2174/157340612800786633




S-Nitrosylation and Attenuation of Excessive Calcium Flux by Pentacycloundecane Derivatives

, 8(3): 361 - 371

Hendrik J.R. Lemmer, Jacques Joubert, Sandra van Dyk, Francois H. van der Westhuizen and Sarel F. Malan


DOI: 10.2174/1573406411208030361




CoMFA and CoMSIA Studies of 1,2-dihydropyridine Derivatives as Anticancer Agents

, 8(3): 372 - 383

Ismail Salama, Mohamed A. O. Abdel-Fattah, Marwa S. Hany, Shaimaa A. El-Sharif, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Gary A. Piazza and Ashraf H. Abadi


DOI: 10.2174/157340612800786598




Synthesis and Activity of [{Cis-PtCl(NH3)2}2µ{Trans-Pt(3-Hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in the Human Ovarian Tumour Models.

, 8(3): 384 - 391

Shahnaz AH Hamad, Philip Beale, Jun Qing Yu, Keith Fisher and Fazlul Huq


DOI: 10.2174/157340612800786642




Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents

, 8(3): 392 - 400

Mohamed A. O. Abdel-Fattah, Mahmoud A. M. El-Naggar, Rasha M. H. Rashied, Bernard D. Gary, Gary A. Piazza and Ashraf H. Abadi


DOI: 10.2174/1573406411208030392




Biological and Anti-inflammatory Evaluation of Two Thiazole Compounds in RAW Cell Line: Potential Cyclooxygenase-2 Specific Inhibitors

, 8(3): 401 - 408

Eva Hamade, Aida Habib, Ali Hachem, Alaa H. Hussein, Malak Abbas, Taghreed Hirz, Mirvat Al Masri and Wissam H. Faour


DOI: 10.2174/1573406411208030401




In vitro Anti-glycation and Anti-oxidant Properties of Synthesized Schiff Bases

, 8(3): 409 - 414

Sabina Jhaumeer-Laulloo, Minu Gupta Bhowon, Shabneez Mungur, Mohamad Fawzi Mahomoodally and Anwar Hussein Subratty


DOI: 10.2174/1573406411208030409




Synthesis and Antiglycation Activity of Kaempferol-3-O-rutinoside (Nicotiflorin)

, 8(3): 415 - 420

Sajan Lal Shyaula, Ghulam Abbas, Hina Siddiqui, Samina A. Sattar, M. Iqbal Choudhary and Fatima Z. Basha


DOI: 10.2174/1573406411208030415




Synthesis and β-Glucuronidase Inhibitory Potential of Benzimidazole Derivatives

, 8(3): 421 - 427

Khalid Mohammed Khan, Momin Khan, Nida Ambreen, Fazal Rahim, Shagufta Naureen, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter


DOI: 10.2174/1573406411208030421




Design, Synthesis and Evaluation of Unique 2,4,5-triaryl Imidazole Derivatives as Novel Potent Aspartic Protease Inhibitors

, 8(3): 428 - 435

Mohd Sajid Khan, Salman Akhtar, S. A. Siddiqui, M. S. Siddiqui, K. V. Srinivasan and J. M. Arif


DOI: 10.2174/1573406411208030428




Generation of Pharmacophore and Atom Based 3D-QSAR Model of Novel Isoquinolin-1-one and Quinazolin-4-one-type Inhibitors of TNFα

, 8(3): 436 - 451

Pradeep Hanumanthappa, Mahesh K. Teli and Rajanikant G. Krishnamurthy


DOI: 10.2174/1573406411208030436




2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

, 8(3): 452 - 461

Khalid Mohammed Khan, Zarbad Shah, Viqar Uddin Ahmad, Momin Khan, Muhammad Taha, Fazal Rahim, Sajjad Ali, Nida Ambreen, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter


DOI: 10.2174/1573406411208030452




Structure-Activity Relationships of Pyrrole Hydrazones as New Anti-Tuberculosis Agents

, 8(3): 462 - 473

Iglika Lessigiarska, Ilza Pajeva, Penka Prodanova, Maya Georgieva and Atanas Bijev


DOI: 10.2174/1573406411208030462




First Study on Antimicriobial Activity and Synergy between Isothiocyanates and Antibiotics Against Selected Gram-Negative And Gram-Positive Pathogenic Bacteria From Clinical And Animal Source

, 8(3): 474 - 480

Carla Dias, Alfredo Aires, Richard N. Bennett, Eduardo A. S. Rosa and Maria J. Saavedra


DOI: 10.2174/1573406411208030474




Synthesis and Biological Evaluation of the Salicylamide and Salicylic Acid Derivatives as Anti-Estrogen Agents

, 8(3): 481 - 490

Yasemin Dundar, Yasemin Ozatik, Orhan Ozatik, Volkan Ergin, Tijen Onkol, Adnan Menevse, Kevser Erol and M. Fethi Sahin


DOI: 10.2174/1573406411208030481




A Quantitative Structure-Activity Relationship Study on a Few Series of Anti-hepatitis C Virus Agents

, 8(3): 491 - 504

Jonish Varshney, Anjana Sharma and Satya P. Gupta


DOI: 10.2174/1573406411208030491




Synthesis and Biological Evaluation of Some New N4-Aryl Substituted 5-Chloroisatin-3-thiosemicarbazones

, 8(3): 505 - 514

Humayun Pervez, Muhammad Ramzan, Muhammad Yaqub, Faiz-ul-Hassan Nasim and Khalid Mohammed Khan


DOI: 10.2174/1573406411208030505




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