Contents

Medicinal Chemistry, Volume 8 - Number 2

Novel Gastrin Receptor-Directed Contrast Agents - Potential in Brain Tumor Magnetic Resonance Imaging

, 8(2): 133 - 137

Alexander Sturzu, Sumbla Sheikh, Uwe Klose, Martin Deeg, Hartmut Echner, Thomas Nagele, Ulrike Ernemann and Stefan Heckl


DOI: 10.2174/157340612800493566




Anticancer Agents for Treatment of Tumors in the Central Nervous System by Correspondent Substituent Substitution and Elucidation by Pattern Recognition Methods

, 8(2): 138 - 144

Ronald Bartzatt


DOI: 10.2174/157340612800493557




Facile Synthesis and Biological Evaluation of Novel Symmetrical Biphenyls as Antitumor Agents

, 8(2): 145 - 150

Jie Zhang, Yanmin Zhang, Xiaoyan Pan, Chen Wang, Zhigang Hu, Sicen Wang and Langchong He


DOI: 10.2174/157340612800493656




Synthesis and Anticancer Activity of Novel Benzimidazole and Benzothiazole Derivatives against HepG2 Liver Cancer Cells

, 8(2): 151 - 162

Amal M. Youssef, Ahmed Malki, Mona H. Badr, Rasha Y. Elbayaa and Ahmed S. Sultan


DOI: 10.2174/157340612800493719




Synthesis and Cytotoxic Evaluation of Quinazolin-4(3H)-one Derivatives Bearing Thiocarbamate, Thiourea or N-Methyldithiocarbamate Side Chains

, 8(2): 163 - 173

Sheng-Li Cao, Hong Xu, Yao Wang, Ji Liao, Jing-Jing Zhang, Zhong-Feng Li, Yan-Wen Guo, Xiao-Rong Li, Xue-Mei Cui and Xingzhi Xu


DOI: 10.2174/157340612800493665




Optimization of Important Early ADME(T) Parameters of NADPH Oxidase-4 Inhibitor Molecules

, 8(2): 174 - 181

Gabor Borbely, Monika Huszar, Attila Varga, Krisztina Futosi, Attila Mocsai, Laszlo Orfi, Miklos Idei, Jozsef Mandl, Gyorgy Keri and Tibor Vantus


DOI: 10.2174/157340612800493674




Design, Synthesis & Biological Evaluation of Some Novel Quinazolinone Scaffolds

, 8(2): 182 - 192

Rahul P. Modh, Amit C. Patel and Kishor H. Chikhalia


DOI: 10.2174/157340612800493610




Synthesis and Anti-HIV Activities of Suramin Conjugates of 3'-Fluoro- 2',3'-dideoxythymidine and 3'-Azido-2',3'-dideoxythymidine

, 8(2): 193 - 197

Hitesh K. Agarwal, Gustavo F. Doncel and Keykavous Parang


DOI: 10.2174/157340612800493737




A Pharmacophore Model Specific to Active Site of CYP1A2 with a Novel Molecular Modeling Explorer and CoMFA

, 8(2): 198 - 207

Hitesh K. Agarwal, Gustavo F. Doncel and Keykavous Parang


DOI: 10.2174/157340612800493601




Molecular Dynamics Simulations of CYP2E1

, 8(2): 208 - 221

Jue Li, Dong-Qing Wei, Jing-Fang Wang, Zheng-Tian Yu and Kuo-Chen Chou


DOI: 10.2174/157340612800493692




Synthesis of a Fluorescently Labeled Compound for the Detection of Arsenic-induced Apoptotic HL60 Cells

, 8(2): 222 - 229

A. Lis Femia, C. Facundo Temprana, M. Silvia Amor, Mariano Grasselli and Silvia del V. Alonso


DOI: 10.2174/157340612800493584




An In Silico Stereo-electronic Comparison of Conventional Pyridinium Oximes and K-oximes for Organophosphate (OP) Poisoning

, 8(2): 230 - 245

Apurba K. Bhattacharjee, Kamil Kuca, Kamil Musilek and Richard K. Gordon


DOI: 10.2174/157340612800493700




Synthesis and Study the Analgesic Effects of New Analogues of Ketamine on Female Wistar Rats

, 8(2): 246 - 251

Abbas Ahmadi, Mohsen Khalili, Ramin Hajikhani, Horiesadat Hosseini, Nasrin Afshin and Babak Nahri-Niknafs


DOI: 10.2174/157340612800493683




2D Chemometrics Analyses of Tetrahydroquinoline and Ethylenediamine Derivatives with Antimalarial Activity

, 8(2): 252 - 265

Humberto Fonseca de Freitas and Marcelo Santos Castilho


DOI: 10.2174/157340612800493575




Synthesis and In Vivo Antimalarial Evaluation of Novel Hydroxyethylamine Derivatives

, 8(2): 266 - 272

Mariana Conceicao de Souza, Triciana Goncalves-Silva, Marcele Moreth, Claudia R.B. Gomes, Carlos Roland Kaiser, Maria das Gracas Muller de Oliveira Henriques and Marcus V.N. de Souza


DOI: 10.2174/157340612800493638




Small Molecule Hydrazide Agents to Inhibit Growth and Proliferation of Mycobacterium Tuberculosis

, 8(2): 273 - 280

Ronald Bartzatt, Suat L.G. Cirillo and Jeffrey D. Cirillo


DOI: 10.2174/157340612800493647




Structure-Activity Relationships of 2-Benzylsulfanylbenzothiazoles: Synthesis and Selective Antimycobacterial Properties

, 8(2): 281 - 292

Vera Klimesova, Jan Koci, Karel Palat, Jirina Stolarikova, Hans-Martin Dahse and Ute Mollmann


DOI: 10.2174/157340612800493593




Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

, 8(2): 293 - 298

Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian and Wenlong Huang


DOI: 10.2174/157340612800493629




Identification of Structural Features for 4-Methyl-3-(6-[Phenyl Methylene] Amino} Pyridine-3-yl)-2h Chromen-2-One Derivatives as Clotting Factor XA Inhibitors

, 8(2): 299 - 307

Kundan B. Ingale and Manish S. Bhatia


DOI: 10.2174/157340612800493728




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