Contents

Medicinal Chemistry, Volume 2 - Number 2

Synthesis of Variously Substituted 3-Phenoxymethyl Quinoxalin-2-Ones and Quinoxalines Capable to Potentiate In Vitro the Antiproliferative Activity of Anticancer Drugs in Multi-Drug Resistant Cell Lines

, 2(2): 113 - 122

Roberta Loddo, Paolo La Colla, Bernardetta Busonera, Gabriella Collu, Giuseppe Paglietti, Sandra Piras, Antonio Carta and Mario Loriga


DOI: 10.2174/157340606776056197




New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells

, 2(2): 123 - 132

D. P. Fairlie, P. G. Parsons, A. J. Lucke and G. M. Boyle


DOI: 10.2174/157340606776056124




Design, Synthesis and Antimalarial Activity of a New Class of Iron Chelators

, 2(2): 133 - 138

Kumkum Srivastava, S. B. Katti, Sunil K. Puri, W. Haq and V. R. Solomon


DOI: 10.2174/157340606776056179




Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7- trimethoxyindole-2-carboxamide (iso-CFI) Analogs of Duocarmycin C2: Synthesis and Biological Evaluation

, 2(2): 139 - 146

John A. Hartley, Moses Lee, Konstantinos Kiakos, Stephen Hudson, Heather Townes, Kaitlin Summerville, Adrienne Scott, Brian Lingerfelt and Bethany Purnell


DOI: 10.2174/157340606776056188




Antiestrogenically Active 2-benzyl-1,1-diarylbut-2-enes: Synthesis, Structure- Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists

, 2(2): 147 - 168

Mary J. Meegan, Daniela M. Zisterer, Andrew S. Knox, Timothy O'Sullivan, Helena M. Smith and David G. Lloyd


DOI: 10.2174/157340606776056142




Curcumin is an Inhibitor of p300 Histone Acetylatransferase

, 2(2): 169 - 174

Len Neckers, Jane Trepel, Sunmin Lee, Eun-Joo Chung, Min-Jung Lee, Yun-Jin Jung and Monica G. Marcu


DOI: 10.2174/157340606776056133




Drug Evolution Concept in Drug Design: 2. Chimera Method

, 2(2): 175 - 189

G. Roman, T. Popek, C. Lazar, T. Kiyota, A. Kluczyk and Y. Konishi


DOI: 10.2174/157340606776056214




FAMS Complex: A Fully Automated Homology Modeling System for Protein Complex Structures

, 2(2): 191 - 201

Mayuko Takeda-Shitaka, Genki Terashi, Chieko Chiba, Daisuke Takaya and Hideaki Umeyama


DOI: 10.2174/157340606776056160




Investigation of the Route of Absorption of Lipid and Sugar Modified Leu- Enkephalin Analogues and Their Enzymatic Stability Using the Caco-2 Cell Monolayer System

, 2(2): 203 - 211

Sherry Wu, Christopher Campbell, Yasuko Koda, Joanne T. Blanchfield and Istvan Toth


DOI: 10.2174/157340606776056205




Mitogen Activated Protein (MAP) Kinases: Development of ATP and Non- ATP Dependent Inhibitors

, 2(2): 213 - 222

Chad N. Hancock, Alba T. Macias, Alexander D. MacKerell, Jr. and Paul Shapiro


DOI: 10.2174/157340606776056151




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