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Medicinal Chemistry

Volume 17, 10 Issues, 2021
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access


Medicinal Chemistry, Volume 15 - Number 6

Review Article

Advances in Structural Biology of ACE and Development of Domain Selective ACE-inhibitors

, 15(6): 574 - 587

Mája Polakovičová* and Josef Jampílek

DOI: 10.2174/1573406415666190514081132

Research Article

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

, 15(6): 588 - 601

Mahmoud A. Al-Sha'er*, Rua'a A. Al-Aqtash and Mutasem O. Taha*

DOI: 10.2174/1573406415666190222125333

Research Article

Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

, 15(6): 602 - 623

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*

DOI: 10.2174/1573406415666181219111511

Research Article

Novel Hybrids of Pyrazolidinedione and Benzothiazole as TZD Analogues. Rationale Design, Synthesis and In Vivo Anti-Diabetic Evaluation

, 15(6): 624 - 633

Michelyne Haroun*

DOI: 10.2174/1573406415666190515093657

Research Article

New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

, 15(6): 634 - 647

Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader

DOI: 10.2174/1573406415666181208104543

Research Article

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

, 15(6): 648 - 658

Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*

DOI: 10.2174/1573406415666181203115957

Research Article

Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

, 15(6): 659 - 675

Mohamed F. Zayed, Sabrin R.M. Ibrahim*, EL-Sayed E. Habib, Memy H. Hassan, Sahar Ahmed and Heba S. Rateb

DOI: 10.2174/1573406414666181109092944

Research Article

Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α

, 15(6): 676 - 684

Christelle Doebelin, Yuanjun He, Sean Campbell, Philippe Nuhant, Naresh Kumar, Marcel Koenig, Ruben Garcia-Ordonez, Mi Ra Chang, William R. Roush, Li Lin, Susan Kahn, Michael D. Cameron, Patrick R. Griffin, Laura A. Solt* and Theodore M. Kamenecka*

DOI: 10.2174/1573406415666190222124745

Research Article

Design, Synthesis and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes

, 15(6): 685 - 692

Tommy F. Mabasa, Babatunde Awe, Dustin Laming and Henok H. Kinfe*

DOI: 10.2174/1573406415666190206232308

Research Article

Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2 ,N4 -Disubstituted Quinazoline-2,4-diamines.

, 15(6): 693 - 704

Nattakarn Pobsuk, Praphasri Suphakun, Supa Hannongbua, Chanin Nantasenamat, Kiattawee Choowongkomon and M. Paul Gleeson*

DOI: 10.2174/1573406415666181219100307

Research Article

Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing

, 15(6): 705 - 714

Rajashekar Sindhu, Hanumanthappa Pradeep and Haravey K. Manonmani*

DOI: 10.2174/1573406415666190206232816


Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
View Full Editorial Board

Nobel Laureate on Editorial Board

Prof. Ferid Murad

COPE Compliant

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Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.

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