Contents

Medicinal Chemistry, Volume 12 - Number 4

Molecular Modeling, de novo Design and Synthesis of a Novel, Extracellular Binding Fibroblast Growth Factor Receptor 2 Inhibitor Alofanib (RPT835)

, 12(4): 303 - 317

Ilya Tsimafeyeu, Frits Daeyaert, Jean-Baptiste Joos, Koen V. Aken, John Ludes-Meyers, Mikhail Byakhov and Sergei Tjulandin


DOI: 10.2174/1573406412666160106154726




Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator

, 12(4): 318 - 327

Kunio Yui, George Imataka and Yohei Kawasaki


DOI: 10.2174/1573406412666160107113725




Discovery and Optimization of 1-(4-chloro-3-(trifluoromethyl)- phenyl)-3-(2-(amino)pyridin-3-yl)ureas as Novel KDR Kinase Inhibitors

, 12(4): 328 - 337

Yu Jiao, Fei Huang, Pengfei Xu, Yanmin Zhang, Shangyan Yang, Danfeng Zhang, Tao Lu and Weifang Tang


DOI: 10.2174/1573406412666151215105149




Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

, 12(4): 338 - 346

Yan Xia, Qiong Duan, Bao-Hua Zhao, Dong-Feng Li and Rui-Bin Hou


DOI: 10.2174/1573406412666151109113007




Identification of New Inhibitors for Human SIRT1: An in-silico Approach

, 12(4): 347 - 361

Balasundaram Padmanabhan, Manjula Ramu, Shruti Mathur, Sruthi Unni and Saravanamuthu Thiyagarajan


DOI: 10.2174/1573406412666160107111612




Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase

, 12(4): 362 - 370

Kamil Musilek, Jan Hambalek, Ondrej Holas, Vlastimil Dohnal and Kamil Kuca


DOI: 10.2174/1573406411666151002125640




Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds

, 12(4): 371 - 393

Ghadeer Suaifan, Mayadah Shehadeh, Hebah Al-Ijel, Khuloud T. Al-Jamal and Mutasem Taha


DOI: 10.2174/1573406411666151002130609




Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole

, 12(4): 394 - 401

Bita Zareian, Sajad Ghadbeighi, Amirali Amirhamzeh, Seyed N. Ostad, Abbas Shafiee and Mohsen Amini


DOI: 10.2174/1573406412666151112125149




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