Contents

Medicinal Chemistry, Volume 1 - Number 3

Application of Bioinformatics in Search for Cleavable Peptides of SARSCoV Mpro and Chemical Modification of Octapeptides

, 1(3): 209 - 213

Qishi Du, Shuqing Wang, Zhiqin Jiang, Weina Gao, Yun Li, Dongqing Wei and Kuo-Chen Chou


DOI: 10.2174/1573406053765468




Effects of Introducing Silicon Isosteres in COX-2 Inhibitors: A Preliminary In Silico Evaluation

, 1(3): 215 - 226

Patrick Englebienne


DOI: 10.2174/1573406053765459




Investigation of Bioisosteric Effects on the Interaction of Substrates/ Inhibitors with the Methionyl-tRNA Synthetase from Escherichia coli

, 1(3): 227 - 237

M. D. Vaughan, P. B. Sampson, E. Daub and J. F. Honek


DOI: 10.2174/1573406053765477




Variously Substituted (Phosphonoacetamido)Oxy Analogues of Geranylgeranyl Diphosphate (GGdP) as GGdP-transferase (GGTase) Inhibitors and Antiproliferative Agents

, 1(3): 239 - 244

Filippo Minutolo, Valentina Asso, Simone Bertini, Laura Betti, Massimiliano Ciriaco, Romano Danesi, Gianbattista Gervasi, Elisa Ghilardi, Elisa Giovanetti and Gino Giannaccini


DOI: 10.2174/1573406053765512




Synthesis and Biological Evaluation of 2-, 3-, and 4-Acylaminocinnamyl-Nhydroxyamides as Novel Synthetic HDAC Inhibitors

, 1(3): 245 - 254

A. Mai, S. Massa, R. Pezzi, S. Valente, P. Loidl and G. Brosch


DOI: 10.2174/1573406053765431




Synthesis and Evaluation of a Novel Gene Reporter Molecule: Detection of b-galactosidase Activity Using 19F NMR of a Fluorinated Vitamin B6 Conjugate+

, 1(3): 255 - 262

Jianxin Yu, Zhenyi Ma, Yingming Li, Kenneth S. Koeneman, Li Liu and Ralph P. Mason


DOI: 10.2174/1573406053765495




Discovery of HIV-1 Integrase Inhibitors through a Novel Combination of Ligand and Structure-based Drug Design

, 1(3): 263 - 275

A. Brigo, G. Iurcu Mustata, J. M. Briggs and S. Moro


DOI: 10.2174/1573406053765440




Aminopyrimidinimino Isatin Analogues: Design and Synthesis of Novel Non- Nucleoside HIV-1 Reverse Transcriptase Inhibitors with Broad- Spectrum Anti-Microbial Properties

, 1(3): 277 - 285

Dharmarajan Sriram, Tanushree Ratan Bal and Perumal Yogeeswari


DOI: 10.2174/1573406053765422




Evaluation of Hyperforin Analogues for Inhibition of 5-lipoxygenase

, 1(3): 287 - 291

Christian Feißt, Dana Albert, Luisella Verotta and Oliver Werz


DOI: 10.2174/1573406053765503




Protein Phosphorylation and Signal Transduction Modulation: Chemistry Perspectives for Small-Molecule Drug Discovery

, 1(3): 293 - 319

T. K. Sawyer, W. C. Shakespeare, Y. Wang, R. Sundaramoorthi, W. S. Huang, C. A. Metcalf III, M. Thomas, B. M. Lawrence, L. Rozamus and J. Noehre


DOI: 10.2174/1573406053765486




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