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Medicinal Chemistry

Volume 17, 10 Issues, 2021
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Articles Ahead of Print




Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc


Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco


DOI: 10.2174/1573406416666201120103913
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Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry


Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*


DOI: 10.2174/1573406416666201106104756
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Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents


Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*


DOI: 10.2174/1573406416666200817160708
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Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound


Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*


DOI: 10.2174/1573406416666201106110117
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Exploring the Molecular Mechanisms of 17β-HSD5-induced Carcinogenicity of Catha edulis via Molecular Modeling Approach


Maria Saeed, Sajda Ashraf, Rashad Alsanosi, Hassan A. Alhazmi, Mohammed AlBratty, Asim Najmi, Asaad Khalid and Zaheer ul Haq*


DOI: 10.2174/1573406416666201005142522
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Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship


M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala


DOI: 10.2174/1573406416666200930113511
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Synthesis and biological evaluation of 4-aminoantipyrine analogues


Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M


DOI: 10.2174/1573406416666201106105303
View Abstract





Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes


Ivana Raković, Jovana Bogojeski*, Katarina Mladenović, Angelina Petrović, Vera Divac, Kristina Mihailović, Biljana Popovska Jovicić, Marina Kostić, Predrag Canović, Nevena Milivojević, Marko Zivanović and Ivana Radojević


DOI: 10.2174/1573406416666200930112442
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Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer


Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny


DOI: 10.2174/1573406416666200925141703
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Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects


Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain


DOI: 10.2174/1573406416666200905125038
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Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells


Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*


DOI: 10.2174/1573406416666200904110828
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Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives


Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale


DOI: 10.2174/1573406416666200817155056
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Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives


Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*


DOI: 10.2174/1573406416999200818150053
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Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies


Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen


DOI: 10.2174/1573406416666200826102051
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Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors


Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*


DOI: 10.2174/1573406416999200818152440
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Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines


Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*


DOI: 10.2174/1573406416666200817164308
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In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARSCoV


Kiran Chunduru*, Runali Sankhe*, Farmiza Begum, Nalini Sodum, Nitesh Kumar, Anoop Kishore, Rekha R. Shenoy, C. Mallikarjuna Rao and Kavitha Saravu


DOI: 10.2174/1573396316999200727125522
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Xanthone: A Promising Antimycobacterial Scaffold


Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*


DOI: 10.2174/1573406416666200619114124
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Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies


Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*


DOI: 10.2174/1573406416666200611103039
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Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies


Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*


DOI: 10.2174/1573406416666200610185654
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Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro


Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*


DOI: 10.2174/1573406416666200602161047
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Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity


Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović


DOI: 10.2174/1573406416666200602152643
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Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds


Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M Aminabhavi, Kumar P Narayan and Vishnu Sutariya


DOI: 10.2174/1573406416666200519085626
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Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors


Lenci Karina Vázquez-Jiménez, Alma Delia Paz-González, Alfredo Juárez-Saldivar, María Laura Uhrig, Rosalía Agusti, Alicia Reyes-Arellano, Benjamín Nogueda-Torres and Gildardo Rivera*


DOI: 10.2174/1573406416666200506084611
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Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities


Amerah M. Al-Soliemy, Thoraya A. Farghaly, Eman M. H. Abbas, Mohamed R. Shaaban*, Mohie E. M. Zayed and Tarek B. A. El-Naggar


DOI: 10.2174/1573406416666200517103435
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Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation


Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai


DOI: 10.2174/1573406416666200420081540
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2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells


Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*


DOI: 10.2174/1573406416666200403075826
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Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines


Benedetta Bocchini, Bruna Goldani, Fernanda S.S. Sousa, Paloma T. Birmann, Cesar A. Brüning, Eder J. Lenardão, Claudio Santi, Lucielli Savegnago and Diego Alves*


DOI: 10.2174/1573406416666200403081831
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The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments


Michalis Platis, Dimitrios Vlachakis, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Mohamed Hamed Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*


DOI: 10.2174/1573406416666200403074742
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Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives


Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*


DOI: 10.2174/1573406416666200121105215
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A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin


Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*


DOI: 10.2174/1573406416666200117120348
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Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents


Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief


DOI: 10.2174/1573406416666191227112648
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Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study


Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*


DOI: 10.2174/1573406415666191206100336
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Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study


Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*


DOI: 10.2174/1573406415666191206095032
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Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH


Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*


DOI: 10.2174/1573406415666191106124016
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Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking


Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*


DOI: 10.2174/1573406415666191122111228
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A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds


Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*


DOI: 10.2174/1573406415666191114123004
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Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

COPE Compliant

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.85

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