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Medicinal Chemistry

Volume 16, 8 Issues, 2020
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access
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In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Articles Ahead of Print


Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer


Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny


DOI: 10.2174/1573406416666200925141703
View Abstract



Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α- Glucosidase Inhibitors for Management of Type 2 Diabetes


Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad Ali Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri


DOI: 10.2174/1573406416666200826101205
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Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors


Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*


DOI: 10.2174/1573406416999200818152440
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Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines


Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*


DOI: 10.2174/1573406416666200817164308
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New oxazolidines inhibit the secretion of IFN-γ and IL-17 by PBMCS from moderate to severe asthmatic patients


Renata Virgínia Cavalcanti Santos*, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo


DOI: 10.2174/1573406416666200910151950
View Abstract




Features, Pharmacological chemistry, molecular mechanism and health benefits of Lemon


Nitika Singh, Nagesndra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*


DOI: 10.2174/1573406416666200909104050
View Abstract


Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents


Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada


DOI: 10.2174/1573406416666200817160708
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Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects


Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain


DOI: 10.2174/1573406416666200905125038
View Abstract


Oreganum Vulgare: In-vitro assessment of cytotoxicity, Molecular docking studies, Antioxidant, and evaluation of anti-inflammatory activity in LPS stimulated RAW 264.7 cells


Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*


DOI: 10.2174/1573406416666200904110828
View Abstract


Indane-1,3-diones: as potential and selective α-glucosidase inhibitors, their synthesis, in vitro and in silico studies.


Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen


DOI: 10.2174/1573406416666200826102051
View Abstract


In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARSCoV


Kiran Chunduru*, Runali Sankhe*, Farmiza Begum, Nalini Sodum, Nitesh Kumar, Anoop Kishore, Rekha R. Shenoy, C. Mallikarjuna Rao and Kavitha Saravu


DOI: 10.2174/1573396316999200727125522
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Synthesis and In Vitro Anti-HCV and Antitumor Evaluation of Schisan-dronic acid derivatives


Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*


DOI: 10.2174/1573406416999200818150053
View Abstract


Structure-Activity Relationship Study of an Alkynylphosphonate and a Vynilphosphonate Analogues of Calcitriol


Silvina Mariela Grioli, Eliana Noelia Alonso, Evangelina Mascaró, Santiago Armando Stabile, María Julia Ferronato, Mario Alfredo Quevedo, Gabriel Radivoy, María Marta Facchinetti, Cristian Alejandro Vitale and Alejandro Carlos Curino*


DOI: 10.2174/1573406416999200818145115
View Abstract


Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide alcohol Derivatives


Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale


DOI: 10.2174/1573406416666200817155056
View Abstract


An Increasing Role of Polyphenols as Novel Therapeutics for Alzheimer’s: A Review


Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo-Sánchez, Luca Rastrelli and Mohammad Amjad Kamal


DOI: 10.2174/1573406415666191105154407
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Xanthone: A Promising Antimycobacterial Scaffold


Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*


DOI: 10.2174/1573406416666200619114124
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Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies


Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*


DOI: 10.2174/1573406416666200611103039
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Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study


Uma Krithika, Prabitha P, Subhankar P. Mandal, Yuvaraj S, Priya D, Ashish D Wadhwani and B. R. Prashantha Kumar*


DOI: 10.2174/1573406416666200610191002
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Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies


Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*


DOI: 10.2174/1573406416666200610185654
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Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro


Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*


DOI: 10.2174/1573406416666200602161047
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Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity


Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović


DOI: 10.2174/1573406416666200602152643
View Abstract View on PubMed


Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds


Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M Aminabhavi, Kumar P Narayan and Vishnu Sutariya


DOI: 10.2174/1573406416666200519085626
View Abstract View on PubMed



Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors


Lenci Karina Vázquez-Jiménez, Alma Delia Paz-González, Alfredo Juárez-Saldivar, María Laura Uhrig, Rosalía Agusti, Alicia Reyes-Arellano, Benjamín Nogueda-Torres and Gildardo Rivera*


DOI: 10.2174/1573406416666200506084611
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Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities


Amerah M. Al-Soliemy, Thoraya A. Farghaly, Eman M. H. Abbas, Mohamed R. Shaaban*, Mohie E. M. Zayed and Tarek B. A. El-Naggar


DOI: 10.2174/1573406416666200517103435
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Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation


Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai


DOI: 10.2174/1573406416666200420081540
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Denouement of Chemicals on Amyotrophic Lateral Sclerosis: Is Green Chemistry the Answer


Faizana Fayaz, Faheem Hyder Pottoo, Sadat Shafi, Mushtaq Ahmad Wani, Sharad Wakode* and Anjali Sharma


DOI: 10.2174/1573406416666200413111330
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2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells


Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*


DOI: 10.2174/1573406416666200403075826
View Abstract View on PubMed


In silico Studies on the Interaction Between Bioactive Ligands and DPPIV: Insights on Potential Candidates for the Treatment of type 2 Diabetes Mellitus


Michelle Cristiane Melo Reis Martins, Simone Queiroz Pantaleao, Michell de Oliveira Almeida, Karen Cacilda Weber and Kathia Maria Honorio*


DOI: 10.2174/1573406416666200129151256
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Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines


Benedetta Bocchini, Bruna Goldani, Fernanda S.S. Sousa, Paloma T. Birmann, Cesar A. Brüning, Eder J. Lenardão, Claudio Santi, Lucielli Savegnago and Diego Alves*


DOI: 10.2174/1573406416666200403081831
View Abstract View on PubMed


The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments


Michalis Platis, Dimitrios Vlachakis, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Mohamed Hamed Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*


DOI: 10.2174/1573406416666200403074742
View Abstract View on PubMed












Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives


Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*


DOI: 10.2174/1573406416666200121105215
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A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin


Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*


DOI: 10.2174/1573406416666200117120348
View Abstract View on PubMed




Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super Family G member 2


Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar and Mohammad Amjad Kamal*


DOI: 10.2174/1573406416666191219143232
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Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents


Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief


DOI: 10.2174/1573406416666191227112648
View Abstract View on PubMed



Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity


Nataša Perin, Maja Cindrić, Peter Vervaeke, Sandra Liekens, Tomislav Mašek, Kristina Starčević and Marijana Hranjec*


DOI: 10.2174/1573406416666191218101427
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Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study


Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*


DOI: 10.2174/1573406415666191206100336
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Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study


Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*


DOI: 10.2174/1573406415666191206095032
View Abstract View on PubMed


Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH


Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*


DOI: 10.2174/1573406415666191106124016
View Abstract View on PubMed



Antitumor Effect of Zwitterions of Imidazolium Derived from L- methionine in BALB/c Mice with Lymphoma L5178Y


Karen C. Vargas-Castro, Ana M. Puebla Pérez, Irma I. Rangel-Salas, Jorge I. Delgado-Saucedo, José B. Pelayo-Vázquez, Elvia Becerra-Martínez, A. Aarón Peregrina-Lucano, Raul R. Quiñonez-Lopez, Gabriela J. Soltero-Reynoso and Sara A. Cortes-Llamas*


DOI: 10.2174/1573406415666191206093754
View Abstract View on PubMed


N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents


Ana Marzo-Mas, Laura Conesa-Milián, Sam Noppen, Sandra Liekens, Eva Falomir*, Juan Murga, Miguel Carda and J. Alberto Marco


DOI: 10.2174/1573406415666191203112406
View Abstract View on PubMed



Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking


Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*


DOI: 10.2174/1573406415666191122111228
View Abstract View on PubMed


A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds


Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*


DOI: 10.2174/1573406415666191114123004
View Abstract View on PubMed


Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review


Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami and Amirhossein Sahebkar*


DOI: 10.2174/1573406415666191031143553
View Abstract View on PubMed






Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies


Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Amany M. M. Al-Mahmoudy, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja and Eatedal H. Abdel-Aal


DOI: 10.2174/1573406415666190904143852
View Abstract View on PubMed


ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives


Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen


DOI: 10.2174/1573406415666190826153001
View Abstract View on PubMed


NMR: From Molecular Mechanism to its Application in Medical Care


Zhenhong Zhang, Xiaohong Meng, Wei Cui, Syed Sayeed Ahmad, Mohammad A. Kamal and Jinguo Zhang*


DOI: 10.2174/1573406415666191111141630
View Abstract View on PubMed



New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities


Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra


DOI: 10.2174/1573406415666190826160251
View Abstract View on PubMed



Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)

Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.85

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