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Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

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  • 31st of 61 in

    Chemistry, Medicinal

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Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 15

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Number 8



Research Article



Research Article



Research Article

New Copper Compounds with Antiplatelet Aggregation Activity

, 15(8): 850 - 862

Mirthala Flores-Garcia, Juan Manuel Fernández-G., Cristina Busqueta-Griera, Elizabeth Gomez, Simon Hernandez-Ortega, Jean Christian Daniel Lamothe-Flores, Virginia Gomez-Vidales, Ana Maria Mejia-Dominguez, Eduardo Angles-Cano and Aurora de la Pena-Diaz*


DOI: 10.2174/1573406415666190222123207


Research Article

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

, 15(8): 863 - 872

Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo


DOI: 10.2174/1573406415666190208124534


Research Article



Research Article



Research Article

Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

, 15(8): 892 - 902

Syeda S. Hamdani, Bilal A. Khan*, Shahid Hameed, Faisal Rashid, Sumera Zaib, Khalil Ahmad, Ehsan U. Mughal and Jamshed Iqbal*


DOI: 10.2174/1573406415666190211162013


Research Article



Articles Ahead of Print



Novel Furan Coupled Quinoline Diamide Hybrid Scaffolds as Potent Antitubercular Agents: Design, Synthesis and Molecular Modelling


Anantacharya Rajpurohit, Satyanarayan Nayak Devappa*, Lokesh Pathak, Siva Ayyanar, Chidambaram Ramaswamy Rishinaradamangalam and Praveen Shoorapani


DOI: 10.2174/1573406415666190904124630
View Abstract View on PubMed


Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives


Natália N. Santiago, Giulianna P. de Alcântara, Juliana Silva da Costa, Samir A. Carvalho, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M. G. Pereira and Edson F. da Silva*


DOI: 10.2174/1573406415666190712115237
View Abstract View on PubMed



New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities


Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra


DOI: 10.2174/1573406415666190826160251
View Abstract View on PubMed





2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management


Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid Mohammed Khan*, Ruqaiya Khalil, Atia Tul Wahab, Zaheer Ul-Haq, Shahnaz Perveen and M. Iqbal Choudhary


DOI: 10.2174/1573406415666190612153150
View Abstract View on PubMed


Abstracts Ahead of Print

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds


Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*


DOI: 10.2174/1573406415666191114123004
View Abstract


Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities


Abdul-Rehman Phull*, Attarad Ali, Akhtar Ali, Sanaullah Abbasi, Muhammad Zia, Muhammad Hassan Khaskheli, Ihsan ul Haq and Mohammad Amjad Kamal


DOI: 10.2174/1573406415666191111143213
View Abstract


NMR: From molecular mechanism to its application in medical care


Zhenhong Zhang, Xiaohong Meng, Wei Cui, Syed Sayeed Ahmad, Mohammad A. Kamal and Jinguo Zhang*


DOI: 10.2174/1573406415666191111141630
View Abstract


Activity Of (-)-Camphene Derivatives Against Mycobacterium tuberculosis In Acidic pH


Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*


DOI: 10.2174/1573406415666191106124016
View Abstract


An increasing role of polyphenols as novel therapeutics for Alzheimer’s: A review


Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo Sanchez, Luca Rastrelli and Mohammad Amjad Kamal


DOI: 10.2174/1573406415666191105154407
View Abstract


Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review


Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami and Amirhossein Sahebkar*


DOI: 10.2174/1573406415666191031143553
View Abstract


Synthesis, characterization, antioxidant activity of β-diketonates, and effects of coordination to copper(II) ion on their activity: DNA, BSA interactions and molecular docking study


Nenad Joksimović, Jelena Petronijević, Nenad Janković, Marijana Kosanić, Dušan Milivojević, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*


DOI: 10.2174/1573406415666191024102520
View Abstract





Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles

Review Article

USP7: Target validation and drug discovery for cancer therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539





Review Article

New perspectives of Alzheimer disease diagnosis - The most popular and future methods

, 11 January 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847


Research Article

Synthesis, characterization and biological activities of new symmetric bis-1,2,3-triazoles with click chemistry

, 1 May 2018; 14(3): 230-241.

Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak


DOI: 10.2174/1573406413666171120165226


Review Article

Is there a link between Vitamin B and multiple sclerosis?

, 1 March 2018; 14(2): 170-180.

Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*


DOI: 10.2174/1573406413666170906123857



Research Article

Cell cycle arrest and apoptosis induction activity of nitidine chloride on acute myeloid leukemia cells

, 2018; 14(1): 60-66.

Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma


DOI: 10.2174/1573406413666170620091543


Research Article

Quinolinic carboxylic acid derivatives as potential multi-target compounds for neurodegeneration: Monoamine oxidase and cholinesterase inhibition

, 2018; 14(1): 74-85.

Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*


DOI: 10.2174/1573406413666170525125231


Research Article

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?

, 1 May 2018; 14(3): 281-292.

Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova , Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*


DOI: 10.2174/1573406414666180112105657


Research Article

Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities

, 1 May 2018; 14(3): 269-280.

Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*


DOI: 10.2174/1573406413666170623083810




Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225



Most Accessed Articles

Cystic Fibrosis Revisited – a Review Study

, 2017; 13(2): 102-109.

Blanka Klimova, Kamil Kuca, Michal Novotny and Petra Maresova


DOI: 10.2174/1573406412666160608113235


New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 2019; 15(4): 360-372.

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda*, Eva Falomir and Celia Martín-Beltrán


DOI: 10.2174/1573406414666180821103604


Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 2019; 15(4): 341-351.

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*


DOI: 10.2174/1573406414666181005143431


USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

, 2019; 15(4): 400-408.

Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo H.F. do Carmo, Maria A. de Resende-Stoianoff, Cláudio Viegas, Patrícia F. Espuri and Marcos J. Marques


DOI: 10.2174/1573406414666181024111522



New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

, 2019; 15(6): 634-647.

Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader


DOI: 10.2174/1573406415666181208104543


Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

, 2019; 15(6): 602-623.

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*


DOI: 10.2174/1573406415666181219111511


Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α

, 2019; 15(6): 676-684.

Christelle Doebelin, Yuanjun He, Sean Campbell, Philippe Nuhant, Naresh Kumar, Marcel Koenig, Ruben Garcia-Ordonez, Mi Ra Chang, William R. Roush, Li Lin, Susan Kahn, Michael D. Cameron, Patrick R. Griffin, Laura A. Solt* and Theodore M. Kamenecka*


DOI: 10.2174/1573406415666190222124745





Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.63

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