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University of Sydney, Australia

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Thank you for your mail. I am very delighted to be the author of this article in your esteemed journal (Medicinal Chemistry, Bentham science publishers ). Glad to say that the quality of your service is very nice. I will surely contribute new research publication to this esteemed journal soon.

Sreekanth Thota
(National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, Brazil)


Medicinal Chemistry

,

Volume 15

-

Number 1



Foreword   Open Access

Foreword

, 15(1): 1

Dimitra Hadjipavlou-Litina


DOI: 10.2174/157340641501181122103125


Biography   Open Access



Review Article



Research Article

Pyrano[3,2-c]quinoline Derivatives as New Class of α-glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in vitro Biological Evaluation and Kinetic Study

, 15(1): 8 - 16

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104




Research Article

Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

, 15(1): 17 - 27

Elda Meta, Chiara Brullo*, Michele Tonelli, Scott G. Franzblau, Yuehong Wang, Rui Ma, Wan Baojie , Beatrice S. Orena, Maria R. Pasca and Olga Bruno


DOI: 10.2174/1573406414666180524084023




Research Article

4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors

, 15(1): 28 - 37

Maheshkumar R. Borkar, Santosh Nandan*, Harish K.M. Nagaraj, Jayashree Puttur, Jisha Manniyodath, Dipankar Chatterji and Evans C. Coutinho *


DOI: 10.2174/1573406414666180525075755




Research Article

Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones

, 15(1): 38 - 50

Felipe R.S. Santos, Jéssica T. Andrade, Carla D.F. Sousa, Joice S. Fernandes, Lucas F. Carmo, Marcelo G.F. Araújo, Jaqueline M.S. Ferreira and José A.F.P. Villar*


DOI: 10.2174/1573406414666180730111954




Research Article

The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents

, 15(1): 51 - 58

Fady N. Akladios, Scott D. Andrew, Samantha J. Boog, Carmen de Kock, Richard K. Haynes and Christopher J. Parkinson*


DOI: 10.2174/1573406414666180525132204




Articles Ahead of Print

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)


Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


View Abstract View on PubMed


The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy


Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*


View Abstract View on PubMed



Inhibition of α-amylase Activity by Zn2+: Insights from Spectroscopy and Molecular Dynamics Simulations


Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*


View Abstract View on PubMed




Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration


Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou


View Abstract View on PubMed


Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells


Swagatika Das, H. Inci Gul, Umashankar Das*, Jan Balzarini, Stephen G. Dimmock and Jonathan R. Dimmock *


View Abstract View on PubMed



New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity


Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader


View Abstract View on PubMed


Abstracts Ahead of Print

Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2,N4-Disubstituted Quinazoline-2,4-diamines.


Nattakarn Pobsuk, Praphasri Suphakun, Supa Hannongbua, Chanin Nantasenamat, Kiattawee Choowongkomon and M. Paul Gleeson*


View Abstract


Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors


Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


View Abstract


Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent Mnk2 inhibitors: design, synthesis, SAR analysis, and evaluation of in vitro anti-leukaemic activity


Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K. C. Basnet, Ben Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*


View Abstract



Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation


Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*


View Abstract



The Substantial Improvement of Amphotericin B Selective Toxicity upon Modification of Mycosamine with Bulky Substituents


Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*


View Abstract


Efficacy of novel Schiff base derivatives as antifungal compounds in combination with approved drugs against Candida albicans


Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*


View Abstract


Synthesis and biological studies of new multifunctional curcumin platforms for anticancer drug delivery


Andrii Bazylevich , Helena Tuchinsky, Eti Zigman-Hoffman, Ran Weissman , Ofer Shpilberg , Oshrat Hershkovitz-Rokah, Leonid Patsenker and Gary Gellerman*


View Abstract


Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity


Ralph C. Gomes, Renata P. Sakata*, Wanda P. Almeida* and Fernando Coelho*


View Abstract


Open Access Articles

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

, 2018; 14(8): 809 - 817

Jamshed Iqbal *, Muhammad S.A. Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath and Peter Langer




Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents

, 2018; 14(7): 674 - 687

Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan*, Shakil Ahmed, Abeer Raza and Shahnaz Perveen




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles




miRNAs as Circulating Biomarkers for Alzheimer’s Disease and Parkinson’s Disease

, 2016; 12(3): 217-225.

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Mazin A. Zamzami, Hani Choudhry, Munvar M. Shaik, Ian A. Tamargo and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030112140


Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

, 2016; 12(3): 204-210.

Ricardo Cabezas, Marco Avila-Rodriguez, Nelson E. Vega-Vela, Valentina Echeverria, Janneth González, Oscar A. Hidalgo, Altair B. Santos, Gjumrakch Aliev and George E. Barreto


DOI: 10.2174/1573406411666151019120444


Recent Updates on the Association Between Alzheimer’s Disease and Vascular Dementia

, 2016; 12(3): 226-237.

Ghulam M. Ashraf, Sandesh Chibber, Mohammad, Syed K. Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh S. Baeesa and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030111820


Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout

, 2017; 13(3): 260-281.

Xiansheng Zhang, Jingwei Wu, Wei Liu, Yuqiang Liu, Yafei Xie, Qian Shang, Zhixing Zhou, Weiren Xu, Lida Tang, Jianwu Wang and Guilong Zhao*


DOI: 10.2174/1573406412666160915163002



New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

, 2016; 12(1): 83-89.

Farid Abrigach, Btissam Bouchal, Olivier Riant, Yohan Mace, Abdelilah Takfaoui, Smaail Radi, Abdelouahad Oussaid, Mohammed Bellaoui and Rachid Touzani


DOI: 10.2174/1573406411666150519111800



Most Accessed Articles

USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539



New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

, 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847



Synthesis and Antibacterial Activity Against MRSA of Pleuromutilin Derivatives Possessing a Mercaptoethylamine Linker

, 2018; 14(6): 585-594.

Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu and You-Zhi Tang*


DOI: 10.2174/1573406414666180416131737


Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

, 2018; 14(6): 550-555.

Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts


DOI: 10.2174/1573406413666171120162420


Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

, 2018; 14(8): 784-790.

Janaína M. de Ávila, Ionara I. Dalcol*, Alessandra O. Pereira, Eveline W. Santos, Adriano Ferraz, Maura Z. Santos, Marco A. Mostardeiro and Ademir F. Morel


DOI: 10.2174/1573406414666180524081650


Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

, 2018; 14(7): 695-708.

Dima A. Sabbah*, Fatima Al-Tarawneh, Wamidh H. Talib, Kamal Sweidan, Sanaa K. Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf and Mohammad S. Mubarak


DOI: 10.2174/1573406414666180412160142




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