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Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

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  • 31st of 61 in

    Chemistry, Medicinal

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Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 15

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Number 5



Biography   Open Access



Editorial   Open Access



Review Article



Review Article

The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy

, 15(5): 459 - 471

Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*


DOI: 10.2174/1573406415666181219101328


Research Article



Research Article

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

, 15(5): 486 - 495

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181218101623


Research Article



Research Article

Inhibition of α-amylase Activity by Zn2+: Insights from Spectroscopy and Molecular Dynamics Simulations

, 15(5): 510 - 520

Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181217114101


Medicinal Chemistry, Volume 15 (2019) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide


Ebrahim Saeedian Moghadam, Farhad Saravani, Ernest Hamel, Zahra Shahsavari, Mohsen Alipour, Saman Hosseinkhani, Seyednasser Ostad and Mohsen Amini*


DOI: 10.2174/1573406415666190425153717
View Abstract View on PubMed


Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro


Sarosh Iqbal*, Ajmal Khan, Rashid Nazir, Shumaila Kiran, Shahnaz Perveen, Khalid Mohammed Khan* and M. Iqbal Choudhary*


DOI: 10.2174/1573406415666190415163309
View Abstract View on PubMed



Helminthicidal and Larvicidal Potentials of Biogenic Silver Nanoparticles Synthesized from Medicinal Plant Momordica charantia


Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh, Rajendra Patil* and Suresh Gosavi


DOI: 10.2174/1573406415666190430142637
View Abstract





Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies


Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Geon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi*


DOI: 10.2174/1573406415666190319101329
View Abstract View on PubMed


Abstracts Ahead of Print

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents


Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao


DOI: 10.2174/1573406415666190712120611
View Abstract


Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives


Natália N. Santiago, Giulianna P. de Alcântara, Juliana Silva da Costa, Samir A. Carvalho, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M. G. Pereira and Edson F. da Silva*


DOI: 10.2174/1573406415666190712115237
View Abstract


Design of Inhibitors for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Enzyme of Leishmania mexicana


Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*


DOI: 10.2174/1573406415666190712111139
View Abstract



Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents


Xiaofeng Bao, Ziyi Liu, Min Ni, Chao Xia, Shunxin Xu, Shengju Yang* and Yu Zhao


DOI: 10.2174/1573406415666190708145639
View Abstract



Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates


Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*


DOI: 10.2174/1573406415666190627103013
View Abstract



Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents


Shaheen Faizia*, Tahira Sarfaraz, Saima Sumbul, Almas Jabeen, Sobia Ahsan Halim, Mohammad Ahmed Mesaik and Zaheer Ul-Haq


DOI: 10.2174/1573406415666190626121650
View Abstract



Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles

Review Article

USP7: Target validation and drug discovery for cancer therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Research Article

Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities

, 1 May 2018; 14(3): 269-280.

Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*


DOI: 10.2174/1573406413666170623083810



Research Article

Cell cycle arrest and apoptosis induction activity of nitidine chloride on acute myeloid leukemia cells

, 2018; 14(1): 60-66.

Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma


DOI: 10.2174/1573406413666170620091543


Research Article

Quinolinic carboxylic acid derivatives as potential multi-target compounds for neurodegeneration: Monoamine oxidase and cholinesterase inhibition

, 2018; 14(1): 74-85.

Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*


DOI: 10.2174/1573406413666170525125231




Review Article

Is there a link between Vitamin B and multiple sclerosis?

, 1 March 2018; 14(2): 170-180.

Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*


DOI: 10.2174/1573406413666170906123857


Review Article

New perspectives of Alzheimer disease diagnosis - The most popular and future methods

, 11 January 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847





Research Article

Molecular interaction and computational analytical studies of pinocembrin for its antiangiogenic potential targeting VEGFR-2: A persuader of metastasis

, 2018; 14(6): 626-640.

Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M.S. Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*


DOI: 10.2174/1573406414666180416125121


Research Article

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?

, 1 May 2018; 14(3): 281-292.

Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova , Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*


DOI: 10.2174/1573406414666180112105657


Research Article

Synthesis, characterization and biological activities of new symmetric bis-1,2,3-triazoles with click chemistry

, 1 May 2018; 14(3): 230-241.

Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak


DOI: 10.2174/1573406413666171120165226



Most Accessed Articles

Predicting the Activity of Antimicrobial Peptides with Amino Acid Topological Information

, 2013; 9(1): 32-44.

Mao Shu, Rui Yu, Yunru Zhang, Juan Wang, Li Yang, Li Wang and Zhihua Lin


DOI: 10.2174/1573406411309010032


USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756


Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 2019; 15(4): 341-351.

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*


DOI: 10.2174/1573406414666181005143431


New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 2019; 15(4): 360-372.

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda*, Eva Falomir and Celia Martín-Beltrán


DOI: 10.2174/1573406414666180821103604


Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

, 2019; 15(4): 417-429.

Dima A. Sabbah*, Ameerah H. Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan A. Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema A. Khalaf and Mohammad S. Mubarak


DOI: 10.2174/1573406414666180912111846



Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

, 2019; 15(4): 400-408.

Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo H.F. do Carmo, Maria A. de Resende-Stoianoff, Cláudio Viegas, Patrícia F. Espuri and Marcos J. Marques


DOI: 10.2174/1573406414666181024111522


Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

, 2019; 15(4): 409-416.

Patrick Hochegger, Johanna Faist, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser and Robert Weis*


DOI: 10.2174/1573406414666181015115101





Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
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