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Medicinal Chemistry

Volume 18, 10 Issues, 2022
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 18

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Number 2



Research Article

Synthesis, Antileishmanial Activity and <i>in silico</i> Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against <i>Leishmania chagasi</i> Amastigotes

, 18(2): 151 - 169

Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor. J.S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior


DOI: 10.2174/1573406417666210216154428


Research Article

Synthesis, Molecular Docking and Mosquitocidal Efficacy of Lawsone and its Derivatives Against the Dengue Vector <i>Aedes aegypti</i> L. (Diptera: Culicidae)

, 18(2): 170 - 180

Antony Stalin*, Paul Dhivya, Ding Lin, Yue Feng, Antony Cruz Asharaja, Munusamy Rajiv Gandhi, Balakrishnan Senthamarai Kannan, Subramani Kandhasamy, Appadurai Daniel Reegan* and Yuan Chen*


DOI: 10.2174/1573406417666210727121654



Research Article



Research Article





Research Article

From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives

, 18(2): 249 - 259

Gabriella Ortore*, Giulio Poli, Adriano Martinelli, Tiziano Tuccinardi, Flavio Rizzolio and Isabella Caligiuri


DOI: 10.2174/1573406417666210511001241


Medicinal Chemistry, Volume 18 (2022) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 18 (2022) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Current Research on Pro-drug Therapies for Parkinson's and Alzheimer's Disease


Cui Huo, Lei Wu, Zhiqiang Jiang, Jiacheng Yang, Zhouyu Wang, Yuzhi Li* and Shan Qian*


DOI: 10.2174/1573406418666211130150821
View Abstract View on PubMed


GreenMolBD: Nature Derived Bioactive Molecules' Database


S. M. Zahid Hosen*, Md. Junaid, Muhammad Shaiful Alam, Maruf Rubayed, Raju Dash, Rasheda Akter, Tania Sharmin, Nusrat Jahan Mouri, Mohammad Ali Moni, Mahmuda Khatun and Mohammad Mostafa


DOI: 10.2174/1573406418666211129103458
View Abstract View on PubMed


Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis


Jessica V. Faria*, Fernanda P.Z. Passos, Paulo H.A. da Costa, Andressa P. de Oliveira, Yasmin O.D. da Cruz, Frederico S. Castelo-Branco, Maria C.S. Lourenço, Silvane M.F. Murta, Policarpo A.S. Junior, Alice M.R. Bernardino, Monica M. Bastos and Nubia Boechat*


DOI: 10.2174/1573406418666211116144952
View Abstract View on PubMed


Discovery of a Novel Small-Molecule Interleukin-6 Inhibitor Through Virtual Screening Using Artificial Intelligence


Yoshiaki Sato, Ikuo Kashiwakura*, Masaru Yamaguchi, Hironori Yoshino, Takeshi Tanaka, Ken Ikeda, Zhengmao Ye, Hirotsugu Komatsu, Takao Matsuzaki and Masato Hosoda


DOI: 10.2174/1573406418666211116144243
View Abstract View on PubMed


Screening of Synthetic Heterocyclic Compounds as Antiplatelet Drugs


Marcel Hrubša, Khondekar Nurjamal, Alejandro Carazo, Nayana Nayek, Jana Karlíčková, Lenka Applová, Indrajit Karmakar, Shamima Parvin, Jaka Fadraersada, Kateřina Macáková, Přemysl Mladěnka* and Goutam Brahmachari*


DOI: 10.2174/1573406417666211026150658
View Abstract View on PubMed






1,2,3-Triazole- and Quinoline-based Hybrids with Potent Antiplasmodial Activity


Isabela A. Graciano, Alcione S. de Carvalho, Fernando de Carvalho da Silva* and Vitor F. Ferreira


DOI: 10.2174/1573406418666211110143041
View Abstract View on PubMed


Abstracts Ahead of Print


2-Substituted Benzoxazoles as Potent Anti-Inflammatory Agents: Synthesis, Molecular Docking and In Vivo Anti-Ulcerogenic Studies


Iqra Hamid, Humaira Nadeem*, Sameen Fatima Ansari, Sonia Khiljee, Inzamam Abbasi, Asma Bukhari, Muazzam Arif and Muhammad Imran*


DOI: 10.2174/1573406418666211220125344
View Abstract


Mannich Bases: Centrality in Cytotoxic Drug Design


Neha V. Bhilare*, Vinayak S. Marulkar, Pramodkumar J. Shirote, Shailaja A. Dombe, Vilas J. Pise, Pallavi L. Salve, Shantakumar M. Biradar, Vishal D. Yadav, Prakash D. Jadhav, Anjali A. Bodhe, Smita P. Borkar, Prachi M. Ghadge, Pournima A. Shelar, Apurva V. Jadhav and Kirti C. Godse


DOI: 10.2174/1573406418666211220124119
View Abstract


Synthesis and Evaluation of bis-Schiff Bases of Carbohydrazide as Antioxidant and Cytotoxic Agents


Sarosh Iqbal*, Shumaila Kiran, Shahida Perveen, Rizwana Malik, Muhammad Taha, Khalid Mohammed Khan*, Shahnaz Perveen and M. Iqbal Choudhary*


DOI: 10.2174/1573406418666211220123403
View Abstract





Published Contents

Open Access Articles


Prospects for Discovering the Secondary Metabolites of <i>Cordyceps</i> Sensu Lato by the Integrated Strategy

, 2021; 17(2): 97 - 120

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*





Most Cited Articles



Research Article

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

, 2019; 15(3): 311-326.

Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha, Koleka Mlisana and Bharti Odhav


DOI: 10.2174/1573406414666180703121815


Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar


DOI: 10.2174/1573406415666190614101253


Research Article

New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; In Vitro α-amylase inhibitory and antioxidant (DPPH and ABTS radical scavenging) activities

, 2019; 15(1): 87-101.

Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


DOI: 10.2174/1573406414666180903162243


Research Article

Helminthicidal and larvicidal potentials of biogenic silver nanoparticles synthesized from medicinal plant momordica charantia

, 2019; 15(7): 781-789.

Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh*, Rajendra Patil* and Suresh Gosavi*


DOI: 10.2174/1573406415666190430142637


Research Article

ZnO nanoparticles catalyst in the synthesis of bioactive fused pyrimidines as anti-breast cancer agents targeting VEGFR-2

, 2019; 15(3): 277-286.

Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim


DOI: 10.2174/1573406414666180912113226


Research Article

iATP: A sequence based method for identifying anti-tubercular peptides

, 2020; 16(5): 620-625.

Wei Chen*, Pengmian Feng and Fulei Nie


DOI: 10.2174/1573406415666191002152441




Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225


Research Article

The inhibition of polysialyltranseferase ST8SiaIV through heparin binding to polysialyltransferase domain (pstd)

, 2019; 15(5): 486-495.

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181218101623


Research Article

Rational design of colchicine derivatives as anti-HIV agents via QSAR and molecular docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756



Research Article

Pyrano[3,2-c]quinoline derivatives as new class of α-glucosidase inhibitors to treat type 2 diabetes: Synthesis, in vitro biological evaluation and kinetic study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104



Most Accessed Articles





Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

, 2022; 18(1): 88-96.

Thaise Martins, Vera L. M. Silva, Artur M. S. Silva, José L. F. C. Lima, Eduarda Fernandes* and Daniela Ribeiro*


DOI: 10.2174/1573406417666201230093207


Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

, 2021; 17(10): 1073-1085.

Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G.S. Lima and Fernando de C. da Silva


DOI: 10.2174/1573406416666201106104756



Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc

, 2021; 17(10): 1129-1139.

Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda*, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco


DOI: 10.2174/1573406416666201120103913





Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

, 2021; 17(10): 1207-1218.

Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*


DOI: 10.2174/1573406416666200817160708


Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

, 2022; 18(2): 151-169.

Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior


DOI: 10.2174/1573406417666210216154428






Editor-in-Chief

graphic
Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

graphic
Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.

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