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Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

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    Chemistry, Medicinal

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Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

,

Volume 15

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Number 6



Biography   Open Access



Perspectives in Medicinal Chemistry   Open Access



Review Article



Research Article



Research Article

Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

, 15(6): 602 - 623

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*


DOI: 10.2174/1573406415666181219111511


Research Article



Research Article



Research Article

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

, 15(6): 648 - 658

Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*


DOI: 10.2174/1573406415666181203115957


Medicinal Chemistry, Volume 15 (2019) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies


Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Maninder Kaur, Manmohan Yadav, Jitender Madan, Satyavathi Kancherla, Raghuvir R. S. Pissurlenkar and Evans C. Coutinho


DOI: 10.2174/1573406415666190531123751
View Abstract View on PubMed


Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates


Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*


DOI: 10.2174/1573406415666190627103013
View Abstract View on PubMed





Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities


Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva and Alexander Zlatkova*


DOI: 10.2174/1573406415666190531121927
View Abstract View on PubMed


Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana


Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*


DOI: 10.2174/1573406415666190712111139
View Abstract View on PubMed



Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents


Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao


DOI: 10.2174/1573406415666190712120611
View Abstract View on PubMed



Abstracts Ahead of Print

Fluoroquinolone-3-carboxamide amino acid conjugates: Synthesis, antibacterial properties and molecular modeling studies


Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Amany M. M. Al-Mahmoudy, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja and Eatedal H. Abdel-Aal


DOI: 10.2174/1573406415666190904143852
View Abstract


Novel furan coupled quinoline diamide hybrid scaffolds as potent antitubercular agents: Design, synthesis and molecular modelling


Anantacharya Rajpurohit, Satyanarayan Nayak Devappa*, Lokesh Pathak, Siva Ayyanar, Chidambaram Ramaswamy Rishinaradamangalam and Praveen Shoorapani


DOI: 10.2174/1573406415666190904124630
View Abstract


The antioxidant, anticarcinogenic and antimicrobial properties of Verbascum thapsus L.


Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari


DOI: 10.2174/1573406415666190828155951
View Abstract


Improvement of the Anticancer Activity of Chlorambucil and Ibuprofen via Calix[4]arene Conjugates


Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, Elena Martínez-Klimova*, Teresa Ramírez-Ápan and Marcos Martínez-García


DOI: 10.2174/1573406415666190826162339
View Abstract



New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities


Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra


DOI: 10.2174/1573406415666190826160251
View Abstract



ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives


Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen


DOI: 10.2174/1573406415666190826153001
View Abstract




Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles

Review Article

USP7: Target validation and drug discovery for cancer therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Review Article

New perspectives of Alzheimer disease diagnosis - The most popular and future methods

, 11 January 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847






Review Article

Is there a link between Vitamin B and multiple sclerosis?

, 1 March 2018; 14(2): 170-180.

Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*


DOI: 10.2174/1573406413666170906123857


Research Article

Quinolinic carboxylic acid derivatives as potential multi-target compounds for neurodegeneration: Monoamine oxidase and cholinesterase inhibition

, 2018; 14(1): 74-85.

Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*


DOI: 10.2174/1573406413666170525125231


Research Article

Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities

, 1 May 2018; 14(3): 269-280.

Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*


DOI: 10.2174/1573406413666170623083810


Research Article

Cell cycle arrest and apoptosis induction activity of nitidine chloride on acute myeloid leukemia cells

, 2018; 14(1): 60-66.

Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma


DOI: 10.2174/1573406413666170620091543



Research Article

Synthesis, characterization and biological activities of new symmetric bis-1,2,3-triazoles with click chemistry

, 1 May 2018; 14(3): 230-241.

Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak


DOI: 10.2174/1573406413666171120165226



Research Article

Molecular interaction and computational analytical studies of pinocembrin for its antiangiogenic potential targeting VEGFR-2: A persuader of metastasis

, 2018; 14(6): 626-640.

Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M.S. Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*


DOI: 10.2174/1573406414666180416125121


Research Article

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?

, 1 May 2018; 14(3): 281-292.

Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova , Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*


DOI: 10.2174/1573406414666180112105657



Most Accessed Articles

Predicting the Activity of Antimicrobial Peptides with Amino Acid Topological Information

, 2013; 9(1): 32-44.

Mao Shu, Rui Yu, Yunru Zhang, Juan Wang, Li Yang, Li Wang and Zhihua Lin


DOI: 10.2174/1573406411309010032


USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 2019; 15(4): 341-351.

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*


DOI: 10.2174/1573406414666181005143431


Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756


New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 2019; 15(4): 360-372.

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda*, Eva Falomir and Celia Martín-Beltrán


DOI: 10.2174/1573406414666180821103604


Cystic Fibrosis Revisited – a Review Study

, 2017; 13(2): 102-109.

Blanka Klimova, Kamil Kuca, Michal Novotny and Petra Maresova


DOI: 10.2174/1573406412666160608113235



Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

, 2019; 15(4): 400-408.

Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo H.F. do Carmo, Maria A. de Resende-Stoianoff, Cláudio Viegas, Patrícia F. Espuri and Marcos J. Marques


DOI: 10.2174/1573406414666181024111522



Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

, 2019; 15(4): 409-416.

Patrick Hochegger, Johanna Faist, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser and Robert Weis*


DOI: 10.2174/1573406414666181015115101




Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
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