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Thank you for your mail. I am very delighted to be the author of this article in your esteemed journal (Medicinal Chemistry, Bentham science publishers ). Glad to say that the quality of your service is very nice. I will surely contribute new research publication to this esteemed journal soon.

Sreekanth Thota
(National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, Brazil)


Medicinal Chemistry

,

Volume 14

-

Number 8



Biography   Open Access



Research Article

Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

, 14(8): 754 - 763

Malik S. Ahmad*, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, Muhammad I. Choudhary, Wojciech T. Markiewicz, Jan Barciszewski and Christian Betzel*


DOI: 10.2174/1573406414666180524095946




Research Article

Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

, 14(8): 764 - 772

Sheng Tang, Yu-Huan Li , Xin-Yue Cheng, Jin-Qiu Yin , Ying-Hong Li , Dan-Qing Song , Yan-Xiang Wang * and Zhan-Dong Liu*


DOI: 10.2174/1573406414666180222093033




Research Article



Research Article

Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

, 14(8): 784 - 790

Janaína M. de Ávila, Ionara I. Dalcol*, Alessandra O. Pereira, Eveline W. Santos, Adriano Ferraz, Maura Z. Santos, Marco A. Mostardeiro and Ademir F. Morel


DOI: 10.2174/1573406414666180524081650




Research Article

Synthesis of Nucleosides and Non-nucleosides Based 4,6-disubstituted-2- oxo-dihydropyridine-3-carbonitriles as Antiviral Agents

, 14(8): 791 - 808

Tarek S. Ibrahim, Hassan A. El-Sayed, Maan T. Khayat, Amany M.M. AL-Mahmoudy, Ahmed H. Moustafa*, Ayat K.S. El-Deen, Sherif A.F. Rostom and Siva S. Panda*


DOI: 10.2174/1573406414666180522123524




Research Article

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

, 14(8): 809 - 817

Jamshed Iqbal *, Muhammad S.A. Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath and Peter Langer


DOI: 10.2174/1573406414666180222091833




Research Article

2-Oxo-1,2,3,4-tetrahydropyrimidines Ethyl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies

, 14(8): 818 - 830

Sarosh Iqbal*, Nimra N. Shaikh, Khalid M. Khan*, Sehrish Naz, Zaheer Ul-Haq, Shahnaz Perveen and Muhammad I. Choudhary*


DOI: 10.2174/1573406414666180525105325




Articles Ahead of Print

Synthesis and Biological Evaluation of Novel 2,3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents


Arturo Coaviche-Yoval, Hector Luna, Ricardo Tovar-Miranda, Marvin Antonio Soriano-Ursua and Jose G. Trujillo-Ferrara*


View Abstract View on PubMed


Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking


Bianca N. M. Silva, Policarpo A. Sales , Alvaro J. Romanha, Silvane M. F. Murta, Camilo H. S. Lima, Magaly G. Albuquerque, Eliane D'Elia, Jose G. de Aquino, Vitor F. Ferreira, Fernando C. Silva, Angelo C. Pinto and Barbara V. Silva*


View Abstract View on PubMed


Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents


Dima A. Sabbah*, Ameerah Hasan Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan Abu Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema Abu Khalaf and Mohammad S. Mubarak


View Abstract View on PubMed


Synthesis and Biological Evaluation of Novel Osthol Derivatives as Potent Cytotoxic Agents


Saleem Farooq*, Javid A. Banday*, Aashiq Hussain, Momina Nazir, Mushtaq A. Qurishi, Abid Hamid and S. Koul*


View Abstract View on PubMed


Synthesis, 2D-QSAR Studies and Biological Evaluation of Quinazoline Derivatives as Potent Anti-Trypanosoma cruzi Agents


Mariela Bollini, Ana María Bruno*, María Eugenia Niño, Juan José Casal, Leandro Daniel Sasiambarrena, Damián Ariel González Valdez, Leandro Battini, Vanesa Rocío Puente and María Elisa Lombardo


View Abstract View on PubMed


Essential Oil from Lippia origanoides (Verbenaceae): Haemostasis and Enzymes Activity Alterations


Maria Luisa Teixeira, Silvana Marcussi, Danubia Aparecida de Carvalho Selvati Rezende, Maisa Lamounier Magalhaes, David Lee Nelson and Maria das Gracas Cardoso


View Abstract View on PubMed


New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents


Dolores Santa Maria*, Rosa M. Claramunt, Jose Elguero, Miguel Carda, Eva Falomir and Celia Martin-Beltran


View Abstract View on PubMed


Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths


Mateusz D. Tomczyk, Anna Byczek Wyrostek, Klaudia Strama, Martyna Wawszków, Przemysław Kasprzycki and Krzysztof Z. Walczak*


View Abstract View on PubMed


New Hybrid Scaffolds based on Hydrazinyl Thiazole Substituted Coumarin; As Novel Leads of Dual Potential; In Vitro α-Amylase Inhibitory and Antioxidant (DPPH and ABTS Radical Scavenging) Activities


Uzma Salar, Khalid Mohammed Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


View Abstract View on PubMed



Abstracts Ahead of Print

Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity


Ralph C. Gomes, Renata P. Sakata*, Wanda P. Almeida* and Fernando Coelho*


View Abstract


Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles


Wei-yuan Yuan, Xue Chen, Ning-ning Liu, Yi-ning Wen, Bei Yang, Graciela Andrei, Robert Snoeck, Yu-hong Xiang, Yong-wei Wu, Zhen Jiang, Dominique Schols, Zhuo-yong Zhang and Qin-pei Wu*


View Abstract


Design, synthesis, antimicrobial and anti-biofilm evaluation, and molecular docking of new substituted fluoroquinazolinones


Mohamed F. Zayed, Sabrin R.M. Ibrahim*, EL-Sayed E. Habib, Memy H. Hassan, Sahar Ahmed and Heba S. Rateb


View Abstract


Pyrrolopyrazoles; Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents


Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed


View Abstract


Synthesis and biological evaluation of polyfluoroalkylated antipyrines and their isomeric O-methylpyrazoles


Natalya Agafonova, Evgeny Shchegolkov*, Yanina Burgart, Victor Saloutin, Alexandra Trefilova, Galina Triandafilova, Sergey Solodnikov, Vera Maslova, Sophia Borisevich, Olga Krasnykh and Sergey Khursan


View Abstract


Small Molecular Leads Differentially Active against HER2 Positive and Triple Negative Breast Cancer Cell Lines


Adnan Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Elias Baydoun and M. Iqbal Choudhary*


View Abstract


Design, synthesis and in vitro evaluation of novel anti-HIV 3-pyrazol-3-yl-pyridin-2-one analogs


Sanjay Kumar, Shiv Gupta, Shraddha Gaikwad, Leila Fotooh Abadi, Late Kamlesh Kumar Bhutani, Smita Kulkarni* and Inder Pal Singh*


View Abstract


Design and synthesis novel sulfonamide-derived triazoles and bioactivity exploration


Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou


View Abstract


Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions


Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo Henrique Fonseca do Carmo, Maria A. de Resende-Stoianoff, Claudio Viegas, Patricia F. Espurie and Marcos J. Marquese


View Abstract



Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles




miRNAs as Circulating Biomarkers for Alzheimer’s Disease and Parkinson’s Disease

, 2016; 12(3): 217-225.

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Mazin A. Zamzami, Hani Choudhry, Munvar M. Shaik, Ian A. Tamargo and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030112140


Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

, 2016; 12(3): 204-210.

Ricardo Cabezas, Marco Avila-Rodriguez, Nelson E. Vega-Vela, Valentina Echeverria, Janneth González, Oscar A. Hidalgo, Altair B. Santos, Gjumrakch Aliev and George E. Barreto


DOI: 10.2174/1573406411666151019120444


Recent Updates on the Association Between Alzheimer’s Disease and Vascular Dementia

, 2016; 12(3): 226-237.

Ghulam M. Ashraf, Sandesh Chibber, Mohammad, Syed K. Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh S. Baeesa and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030111820


Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout

, 2017; 13(3): 260-281.

Xiansheng Zhang, Jingwei Wu, Wei Liu, Yuqiang Liu, Yafei Xie, Qian Shang, Zhixing Zhou, Weiren Xu, Lida Tang, Jianwu Wang and Guilong Zhao*


DOI: 10.2174/1573406412666160915163002



New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

, 2016; 12(1): 83-89.

Farid Abrigach, Btissam Bouchal, Olivier Riant, Yohan Mace, Abdelilah Takfaoui, Smaail Radi, Abdelouahad Oussaid, Mohammed Bellaoui and Rachid Touzani


DOI: 10.2174/1573406411666150519111800



Most Accessed Articles

USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

, 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847



Drug Design, Synthesis and In Vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors

, 2018; 14(1): 44-52.

Sundeep Kadasi, Thadeu E.M.M. Costa, Neha Arukala, Mallika Toshakani, Chaitanya Duggineti, Sreekanth Thota, Sayan D. Gupta, Shiva Raj, Carmen Penido, Maria G. Henriques and Nulgumnalli M. Raghavendra*


DOI: 10.2174/1573406413666170623085534


Synthesis and Antibacterial Activity Against MRSA of Pleuromutilin Derivatives Possessing a Mercaptoethylamine Linker

, 2018; 14(6): 585-594.

Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu and You-Zhi Tang*


DOI: 10.2174/1573406414666180416131737



Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

, 2018; 14(6): 550-555.

Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts


DOI: 10.2174/1573406413666171120162420



A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

, 2018; 14(4): 387-393.

Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino and Enrico Millo*


DOI: 10.2174/1573406413666171120164702



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