Contents

Letters in Drug Design & Discovery, Volume 7 - Number 6

Graphical Abstracts

, 7(6): i - iv


DOI: 10.2174/157018010791306506




Synthesis and Evaluation of Estradiol Derivatives as Anti-Breast Cancer Agents

, 7(6): 389 - 394

John S. Cooperwood, Jesse Edwards, Musiliyu Musa, Devora Simmons, Abdul D. Mian, Kwon-kyun Park and Zhongliang Wan


DOI: 10.2174/157018010791306551




Self-Organizing Molecular Field Analysis on Pyridazine Analogues as Protein Tyrosine Phosphatase 1B (PTP 1B) Inhibitors

, 7(6): 395 - 401

Suresh Thareja, Saurabh Aggarwal, Tilak Raj Bhardwaj and Manoj Kumar


DOI: 10.2174/157018010791306605




Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors

, 7(6): 402 - 408

Arumugam Kodimuthali, Rajesh Gupta, Kishore Venkata Laxmi Parsa, Padala Lakshmi Prasunamba and Manojit Pal


DOI: 10.2174/157018010791306542




Assessing Drugs for their Cardio-Toxicity

, 7(6): 409 - 414

Anwar Rayan, Mizied Falah, Jamal Raiyn, Hafiz Mawassi and Nur-Eldin Raiyn


DOI: 10.2174/157018010791306515




Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

, 7(6): 415 - 420

Jinpei Zhou, Hai Qian, Huibin Zhang, Hui Gao, Wenlong Huang, Xiaoyun Zhu, Shuaijian Ni and Chuntao Zhang


DOI: 10.2174/157018010791306560




Design and Synthesis of Novel 1,3-Dioxane-2-carboxylic Acid Derivatives as PPARα/γ Dual Agonists

, 7(6): 421 - 429

Harikishore Pingali, Mukul Jain, Shailesh Shah, Pankaj Makadia, Pandurang Zaware, Jeevankumar Jamili, Kalapatapu V.V.M. Sairam, Pravin Patil, Dinesh Suthar, Suresh Giri, Harilal Patel and Pankaj Patel


DOI: 10.2174/157018010791306533




Pyrrole-Based Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics

, 7(6): 430 - 437

Atanas Bijev and Maya Georgieva


DOI: 10.2174/157018010791306588




Application of Molecular Topology to the Search of Novel NSAIDs: Experimental Validation of Activity

, 7(6): 438 - 445

Maria Galvez-Llompart, Rosa M. Giner, Maria C. Recio, Sanzio Candeletti and Ramon Garcia-Domenech


DOI: 10.2174/157018010791306597




Synthesis and Biological Evaluation of Novel Bioisosteric Analogues of Dimebon™

, 7(6): 446 - 451

Alexandre Vasilevich Ivachtchenko, Eugene Borisovich Frolov, Oleg Dmitrievich Mitkin, Sergey Evgenevich Tkachenko and Alexandre Khvat


DOI: 10.2174/157018010791306579




New Limonene-Hybrid Derivatives with Anti-T. cruzi Activity

, 7(6): 452 - 460

G. Alvarez, A. Gerpe, D. Benitez, F. Garibotto, S. Zacchino, C. S. Graebin, R. Gomes da Rosa, V. L. Eifler-Lima, M. Gonzalez and H. Cerecetto


DOI: 10.2174/157018010791306524




Design, Synthesis and 3-D Characterization of 1-Benzenesulfonyl-1,2,3,4- Tetrahydroquinolines as Lead Scaffold for Antiparasitic Drug

, 7(6): 461 - 470

R.J. Pagliero, A.B. Pierini, R. Brun and M.R. Mazzieri


DOI: 10.2174/157018010791306614




Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

, 7(6): 471 - 475

Yuanyuan Zhang, Guangmin Chen, Yabiao Weng, Renliang Li, Yuliang Wang and Yuzhong Wang


DOI: 10.2174/157018010791306498




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